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Reposted by László Tora

Gert Jan C Veenstra @gertjanveenstra.bsky.social · 10h

Today it was announced that Sir John Gurdon passed away.
His ground-breaking discovery was that differentiated cells can be reprogrammed. He was a creative and distinguished developmental biologist, a kind person with a great inquisitive mind and original ideas
www.cam.ac.uk/research/new...

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

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Gert Jan C Veenstra @gertjanveenstra.bsky.social · 9h

With self-deprecating humor, Sir John loved to tell the story of his Biology teacher (1949)

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László Tora @tlaszlo.bsky.social · 15d

Read the new version of our manuscript doi.org/10.1101/2025...

Novel insights into the structure and evolution of the human SAGA complex by affinity-ligand purification

Human SAGA is a 20-subunit complex that stimulates transcription and is essential for development. The most prominent addition to SAGA in metazoans compared to yeast is a 150kDa splicing-factor module...

doi.org

László Tora @tlaszlo.bsky.social · 28d

Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site: network.febs.org/posts/febs-a...

FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics

The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...

network.febs.org

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Kurianlab @kurianlab.bsky.social · Sep 6

www.sciencedirect.com/science/arti...

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as t…

www.sciencedirect.com

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Karsten Rippe @karsten-rippe.bsky.social · Aug 21

"In our view, it [hexanediol] should thus be avoided and not be used as evidence for the formation of an assembly via phase separation or the fluid-like nature of a condensate in vitro or in vivo." doi.org/10.1038/s414...

Current practices in the study of biomolecular condensates: a community comment - Nature Communications

The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes1...

doi.org

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László Tora @tlaszlo.bsky.social · Aug 29

Read this interesting preprint from the lab of Krishnamurthy Natarajan: Cotranslational assembly confers specificity for in vivo target heterodimerization of paralogous H2B-like TAF12 proteins in the human fungal pathogen Candida albicans

doi: doi.org/10.1101/2025...

Cotranslational assembly confers specificity for in vivo target heterodimerization of paralogous H2B-like TAF12 proteins in the human fungal pathogen Candida albicans

The fidelity of assembly of multiprotein complexes is essential for the formation of stable and functional protein complexes that are critical for cell growth and survival. In this context, TBP-associ...

doi.org

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László Tora @tlaszlo.bsky.social · Aug 29

Could you add me please. Thanks. László Tora

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Shiori Iida @shiori-iida.bsky.social · Aug 29

One more movie!
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)

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László Tora @tlaszlo.bsky.social · Aug 12

Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...

Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination

In human cells, large multi-protein transcription co-activators, such as chromatin remodelers or histone acetyltransferases, play critical roles in gene-expression regulation and are often implicated ...

doi.org

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Wendy Bickmore @wbickmor.bsky.social · May 28

Exquisite work. Well done to the whole team.

Daniel Ibrahim @danielibrahim.bsky.social · May 27

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

rdcu.be

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Nacho Molina @molinalab.bsky.social · May 17

🚨 New preprint out! Do you think Single Molecule Footprinting and Fiber-seq are super cool but aren't sure how to unlock their full potential? HiddenFoot can help you: www.biorxiv.org/content/10.1...

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László Tora @tlaszlo.bsky.social · May 1

Friday we celebrated my 40 years of scientific career in France, with present and past lab members and many friends. It was a fantastic day full of emotions, memories and great science. Thanks for making the day so memorable !

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Arnaud Krebs @arnaudkr.bsky.social · Apr 2

The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...

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Arnaud Krebs @arnaudkr.bsky.social · Mar 26

Two more weeks to send us your abstract! >20 abstract selected talks. Priority to junior scientists and cool biology on gene regulation (DNA/RNA/protein). Come to meet the world leaders in single molecule genomics and single molecule imaging! Help shaping the future of the field in the workshops!

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László Tora @tlaszlo.bsky.social · Mar 24

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László Tora @tlaszlo.bsky.social · Mar 21

PMID: 40106549, DOI: 10.1126/sciadv.adr1492

László Tora @tlaszlo.bsky.social · Mar 21

Read our collaborative paper
@longchrom.bsky.social and @molinalab.bsky.social
showing that disruption of NuA4 and ATAC coactivator complexes cause gene-specific transcript buffering, suggesting that cells dynamically adjust RNA export/degradation to sustain cellular homeostasis.

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Silas Maniatis @manimota.bsky.social · Mar 1

www.cell.com/cell/fulltex...

Safeguarding the future of biomedical science in the United States

NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...

www.cell.com

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Oded Rechavi @odedrechavi.bsky.social · Mar 1

Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW!
woodstock.img.cas.cz

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Xin Gu Lab at DFCI/HMS @xingulab.bsky.social · Feb 24

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...

www.biorxiv.org

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FragileNucleosome @fnucleosome.bsky.social · Feb 23

‼️ This Wednesday! Don’t forget to register as we host three amazing ECR scientists!
@manucazottes.bsky.social @robertadolling1.bsky.social
@leandrosboukas.bsky.social

⚡️Our recurring registration link:

us06web.zoom.us/webinar/regi...

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Maria Polychronidou @mpolychronidou.bsky.social · Feb 22

Interesting piece on the role of intrinsically disordered regions in #transcriptionfactor specificity, target search etc. ➡️ www.nature.com/articles/s41... #generegulation

Intrinsically disordered regions as facilitators of the transcription factor target search - Nature Reviews Genetics

Intrinsically disordered domains (IDRs) are increasingly appreciated as important components of protein function. This Perspective discusses the emerging evidence for IDRs from transcription factors a...

www.nature.com

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Christof Gebhardt @gebhardtlab.bsky.social · Feb 21

Search gets faster, binding longer, bound fraction of cohesin and CTCF goes up, especially at and after ZGA

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Christof Gebhardt @gebhardtlab.bsky.social · Feb 21

Single molecules, in living zebrafish embryos, during hour-long period of development: Jonas' work on binding kinetics of cohesin and CTCF around ZGA now online. Great collab with labs of @lucagiorgetti.bsky.social @akispapantonis.bsky.social
doi.org/10.1038/s414...

Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis - Nature Communications

Using single-molecule tracking of cohesin and CTCF during zebrafish embryogenesis, the molecular kinetics underlying chromatin architecture formation was revealed and gradual emergence of chromatin st...

doi.org

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