Nathanael Caveney
@caveneylab.ca
Assistant Professor, PharmTox, University of Toronto. Signalling, structural biology, protein engineering. 🇨🇦
https://caveneylab.ca
https://caveneylab.ca
Reposted by Nathanael Caveney
I'm on the job market. Including my graduate student days, here is my experience.
18 yrs of protein biochemistry
17 yrs of assay design
16 yrs of science writing
11 yrs of membrane proteins
11 yrs of eukaryotes
8 yrs of cryo-electron microscopy
7 yrs of X-ray crystallography
7 yrs of prokaryotes
18 yrs of protein biochemistry
17 yrs of assay design
16 yrs of science writing
11 yrs of membrane proteins
11 yrs of eukaryotes
8 yrs of cryo-electron microscopy
7 yrs of X-ray crystallography
7 yrs of prokaryotes
December 2, 2025 at 8:19 PM
I'm on the job market. Including my graduate student days, here is my experience.
18 yrs of protein biochemistry
17 yrs of assay design
16 yrs of science writing
11 yrs of membrane proteins
11 yrs of eukaryotes
8 yrs of cryo-electron microscopy
7 yrs of X-ray crystallography
7 yrs of prokaryotes
18 yrs of protein biochemistry
17 yrs of assay design
16 yrs of science writing
11 yrs of membrane proteins
11 yrs of eukaryotes
8 yrs of cryo-electron microscopy
7 yrs of X-ray crystallography
7 yrs of prokaryotes
I’ve been out of the bacterial envelope game for a while but this seems like an excellent opportunity! 👀 (plus Canada looks pretty nice these days 😅)
If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.
December 2, 2025 at 5:43 PM
I’ve been out of the bacterial envelope game for a while but this seems like an excellent opportunity! 👀 (plus Canada looks pretty nice these days 😅)
Reposted by Nathanael Caveney
If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.
December 2, 2025 at 3:21 PM
If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.
Reposted by Nathanael Caveney
Structural Insights into Biased Signaling at Chemokine Receptor CCR7 www.biorxiv.org/content/10.1101/2025.11.24.690334v1 #cryoem
November 28, 2025 at 8:10 AM
Structural Insights into Biased Signaling at Chemokine Receptor CCR7 www.biorxiv.org/content/10.1101/2025.11.24.690334v1 #cryoem
Reposted by Nathanael Caveney
Fred Hutch's Immunotherapy Integrated Research Center is recruiting an Open Rank Faculty position to lead a laboratory-based program focused on tumor immunology and cancer immunotherapy with a strong vision/path toward clinical translation.
Learn more: https://apply.interfolio.com/176403
Learn more: https://apply.interfolio.com/176403
November 26, 2025 at 12:51 AM
Fred Hutch's Immunotherapy Integrated Research Center is recruiting an Open Rank Faculty position to lead a laboratory-based program focused on tumor immunology and cancer immunotherapy with a strong vision/path toward clinical translation.
Learn more: https://apply.interfolio.com/176403
Learn more: https://apply.interfolio.com/176403
Reposted by Nathanael Caveney
Don’t forget to vaccinate boys. Cervical cancer isn’t the only HPV driven cancer and unvaccinated boys can transmit to others who are unvaccinated.
#CervicalCancer could be the first cancer EVER in the world to be eliminated, if:
9️⃣0️⃣% of girls are vaccinated
7️⃣0️⃣% of women are screened
9️⃣0️⃣% of women with cervical cancer receive treatment
Learn more: bit.ly/47GIbzd #EndCervicalCancer
9️⃣0️⃣% of girls are vaccinated
7️⃣0️⃣% of women are screened
9️⃣0️⃣% of women with cervical cancer receive treatment
Learn more: bit.ly/47GIbzd #EndCervicalCancer
November 24, 2025 at 3:43 AM
Don’t forget to vaccinate boys. Cervical cancer isn’t the only HPV driven cancer and unvaccinated boys can transmit to others who are unvaccinated.
Reposted by Nathanael Caveney
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
ubc.wd10.myworkdayjobs.com
November 18, 2025 at 11:52 PM
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Reposted by Nathanael Caveney
It should go without saying that the disclosure of personal demographic information that was promised confidentiality to a government committee by the Tri-Council would be the most fundamental breach of ethics and pose a genuine danger to the safety of Canadian researchers.
October 31, 2025 at 2:39 PM
It should go without saying that the disclosure of personal demographic information that was promised confidentiality to a government committee by the Tri-Council would be the most fundamental breach of ethics and pose a genuine danger to the safety of Canadian researchers.
Reposted by Nathanael Caveney
Launch your independent research career in beautiful Toronto!
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Principal Investigator - Early Career in Cancer Biology - Toronto (City), Ontario (CA) job with Princess Margaret Cancer Centre | 12845320
We are seeking an early-career faculty Scientist at Assistant Professor level to establish an independent research program in Cancer Biology.
www.nature.com
October 10, 2025 at 12:46 PM
Launch your independent research career in beautiful Toronto!
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Reposted by Nathanael Caveney
Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 3, 2025 at 6:44 PM
Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nathanael Caveney
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
September 30, 2025 at 9:52 AM
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
Reposted by Nathanael Caveney
I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!
September 26, 2025 at 7:47 AM
I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!
Another wild paper from Jan Burian et al! Modern day gold mining w/ cutting edge sequencing tech! ⛏️
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome - Nature Biotechnology
Optimized long-read sequencing constructs megabase-scale genome assemblies from complex soil samples.
www.nature.com
September 20, 2025 at 1:37 AM
Another wild paper from Jan Burian et al! Modern day gold mining w/ cutting edge sequencing tech! ⛏️
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
Reposted by Nathanael Caveney
📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun!
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
September 19, 2025 at 2:56 PM
📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun!
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
Reposted by Nathanael Caveney
In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science.
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
September 18, 2025 at 9:30 PM
In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science.
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
Reposted by Nathanael Caveney
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
‘We expect that this approach may be useful for cryo-EM analysis of other small particles near or below the theoretical size limit.’ 🤯
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 9:07 PM
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
Reposted by Nathanael Caveney
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
Reposted by Nathanael Caveney
‼️ Notice of upcoming funding opportunity!
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
August 27, 2025 at 7:36 PM
‼️ Notice of upcoming funding opportunity!
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
Reposted by Nathanael Caveney
Wow. Check this out.
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Paris said au revoir to cars. Air pollution maps reveal a dramatic change.
Air pollution fell substantially as the city restricted car traffic and made way for parks and bike lanes.
www.washingtonpost.com
August 30, 2025 at 9:15 PM
Wow. Check this out.
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Reposted by Nathanael Caveney
Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 13, 2025 at 6:26 PM
Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nathanael Caveney
🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
July 25, 2025 at 7:21 PM
🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
🚨 Two weeks left to apply! 🚨 #facultyjobs
Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Pharmacology and Toxicology
Assistant Professor - Pharmacology and Toxicology
jobs.utoronto.ca
July 21, 2025 at 4:53 PM
🚨 Two weeks left to apply! 🚨 #facultyjobs
Reposted by Nathanael Caveney
Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Pharmacology and Toxicology
Assistant Professor - Pharmacology and Toxicology
jobs.utoronto.ca
July 21, 2025 at 4:19 PM
Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...
Reposted by Nathanael Caveney
Sharing some of my PhD work that just came out today.
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
July 2, 2025 at 9:24 PM
Sharing some of my PhD work that just came out today.
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
Reposted by Nathanael Caveney
Our friends in Pharmacology + Toxicology at the @uoftmedicine.bsky.social @uoft.bsky.social are looking for an assistant professor! The successful candidate will also become a member of the Acceleration Consortium. Apply now: jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Pharmacology and Toxicology
Assistant Professor - Pharmacology and Toxicology
jobs.utoronto.ca
June 19, 2025 at 1:54 PM
Our friends in Pharmacology + Toxicology at the @uoftmedicine.bsky.social @uoft.bsky.social are looking for an assistant professor! The successful candidate will also become a member of the Acceleration Consortium. Apply now: jobs.utoronto.ca/job/Toronto-...