'The mechanisms controlling the inclusion of new B cell clones into spontaneous germinal centers (GCs) remain unclear. Using CRISPR-Cas9, we generated 2 autoreactive B cell receptor knock-in strains, M05 and G55, based on B cell receptors from WT GC B cells in WT:564Igi chimeras'

I've got a PSA to the T cell receptor researchers of #immunosky to let you know about a new paper we've just got out: doi.org/10.1016/j.im...

This covers how our field is handling the sets of germline #TCR genes used in our research. Maybe not the most glamorous topic, but it’s kind of a big deal…

FFS.

Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social

Check out this week's newsletter, featuring @clareobio.bsky.social!

Thrilled to be featured in GenomeWeb! 🧬

Stuck behind the paywall? We got you. Here's the TL;DR on how Clareo is pioneering the next generation of immune profiling with full-length antibody sequencing.

Find it here: lnk.bio/clareobio

#Biotech #Genomics #LongReads #Immunology

🌟 Meet "Rosie" - our new @pacbio.bsky.social Vega sequencer! Named after Rosalind Franklin, she'll supercharge our ProfilAIR & GenotypAIR services with faster, more comprehensive B & T cell receptor profiling. Better data = better biomarkers, faster vaccine design, and more precise therapeutics!

Big win for science: The US senate rejects 40% cuts to NIH funding and instead proposes $400M increase. A clear sign that Congresd is standing behind biomedical research www.nature.com/articles/d41...

Pospelova et al. present a comparative analysis of full-length sequences of IG/TR loci across 46 mammalian species, demonstrating these as rapidly evolving genomic regions, with implications for immunogenomics.

🔗 doi.org/10.1093/molbev/msaf152

#evobio #molbio

Know an Evolutionary Genomicist looking for a faculty position? Join us in EEB @utknoxville.bsky.social Position is open for studying any organism, but personally I have some botany bias. 🌱 Apply before Sept 19 for full consideration. apply.interfolio.com/170735 Please share widely. Thanks!

Are you an immunologist working towards your first R01?

Please join @aai.org and take advantage of programs like our Grant Review for Immunologists Program www.aai.org/Careers/GRIP

We pair early career principal investigators with established mentors. Send me a chat for more info

5/6 What can we do now?
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍

iuis.org/committees/n...

6/6 📄 Read the full commentary:
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social

1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology

An overview of the future of IG and TR gene nomenclature www.immunoinformaticsjournal.com/article/S266...

@yanasafonova.bsky.social @elisarosix.bsky.social

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

@guryaari.bsky.social giving awesome overview of ML approaches for AIRR-seq data - FOCiS 2025
@airr-community.bsky.social

@ayeletperes.bsky.social providing excellent overview of AIRR-seq tools at FOCiS 2025
@airr-community.bsky.social

@williamlees.bsky.social highlighting useful AIRR-C resources at FOCiS 2025 in Boston
@airr-community.bsky.social
@focisimmunology.bsky.social

Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...

Nope!

New preprint from our group in collaboration with the awesome Prof. Ranjan Sen (NIH). We show that IGH polymorphisms establish inter-individual differences in the pro-B antibody repertoire that persist into the naive B cell pool. Oscar L. Rodriguez is killing it! www.biorxiv.org/content/10.1...