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Elisa Rosati Scalchi @elisarosix.bsky.social · 1d

Statistics on 100 million people
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.

This is mind blowing 🤯

www.nature.com/articles/s41...

Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

www.nature.com

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Reposted by Elisa Rosati Scalchi

Corey Watson @cdubsig.bsky.social · Aug 29

Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social

The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences

The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…

www.sciencedirect.com

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Elisa Rosati Scalchi @elisarosix.bsky.social · Jun 28

6/6 📄 Read the full commentary:
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social

Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era

For over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has …

www.sciencedirect.com

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Elisa Rosati Scalchi @elisarosix.bsky.social · Jun 28

5/6 What can we do now?
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍

iuis.org/committees/n...

T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee » IUIS

Since this Sub-Committee has not addressed MHC/HLA nomenclature for several decades, the name of the Sub-Committee has been changed to “T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee”…

iuis.org

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Elisa Rosati Scalchi @elisarosix.bsky.social · Jun 28

4/6 Look up the work of the @iuis-online.bsky.social IG/TR Nomenclature Sub-Committee.
They’re urging caution and precision:
➡️ Don’t rush to name
➡️ Wait for sufficient genomic context
➡️ Use consistent interim strategies for gene reporting
#IUIS #GenomicsPolicy

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Elisa Rosati Scalchi @elisarosix.bsky.social · Jun 28

3/6 The problem?
Old naming rules assumed gene order and structure were mostly conserved.
Now we know that’s not always true.
Assigning permanent names too soon could mislead downstream research.
#NomenclatureMatters #IGTR

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Elisa Rosati Scalchi @elisarosix.bsky.social · Jun 28

2/6 For 30+ years, the IG/TR gene naming system worked well—standardized, community-supported, and extended across species.
But things have changed…
Genomic sequencing is exposing extreme structural variation across individuals and species.
🧬🔍

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Elisa Rosati Scalchi @elisarosix.bsky.social · Jun 28

1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology

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Reposted by Elisa Rosati Scalchi

Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 9

This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!

@KingOfPathogens @kingofpathogens.bsky.social · Jun 9

We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses

IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

www.science.org

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Elisa Rosati Scalchi @elisarosix.bsky.social · May 28

And the second day of #ATCR25 also came to an end. Felt the meeting was a real fresh air of ideas. Super glad I joined. The best part is always to meet with old friends, and the #goodscience of course 😉
I love the location in Antwerp too 😍

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Elisa Rosati Scalchi @elisarosix.bsky.social · May 27

First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research

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Reposted by Elisa Rosati Scalchi

Simon Fisher @profsimonfisher.bsky.social · May 2

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n

Four images to illustrate some prominent single-gene myths. Top left shows a photograph of a person deftly rolling their tongue into a U-shape. Top right shows a photograph of a person’s ear, highlighting the shape and features of the earlobe and cartilage. Bottom left shows a close-up photograph of a person’s eye, with a vivid blue colouration. Bottom right shows a photograph of a person poised to write with their left hand on the blank white page of a spiral-bound notebook.

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Reposted by Elisa Rosati Scalchi

Marc Veldhoen @marcveld.bsky.social · May 3

'Unparalleled' snake antivenom made from man bitten 200 times

The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.

www.bbc.com/news/art...
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'Unparalleled' snake antivenom made from man bitten 200 times

Scientists hope to make a universal antivenom from the extraordinary blood of a man exposed to snake venom for decades.

www.bbc.com

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Reposted by Elisa Rosati Scalchi

Eric Topol @erictopol.bsky.social · May 1

New @science.org
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...

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Reposted by Elisa Rosati Scalchi

Jamie Heather @jamieheather.bsky.social · Apr 9

Cool pre-print in my feeds this morning, using a neat trick weighting TCRs by similarity prior to DGE better resolve differential usage. Seems to be a clever trick to make TCRseq behave a little more like regular RNAseq data and better use regular stats/tools:

www.biorxiv.org/content/10.1...

Differential T cell receptor gene expression analysis using the Wilcoxon test with similarity-based weighting

To better understand immune responses, comparing the abundance of T cell receptors (TCRs) between conditions can provide insights into which T cells have proliferated or were involved in immune activa...

www.biorxiv.org

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Elisa Rosati Scalchi @elisarosix.bsky.social · Apr 3

www.nature.com/articles/s41...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

www.nature.com

Reposted by Elisa Rosati Scalchi

Jeff Mold @jeffmold.bsky.social · Mar 22

This looks super interesting www.biorxiv.org/content/10.1...

Ultra long-lived plasma cells in the human small intestine produce microbiota-reactive IgA antibodies

A large fraction of the intestinal microbiota is highly coated with secretory IgA, and bacteria-specific IgA is believed to shape the composition of the microbiota. A hallmark of the adaptive immune s...

www.biorxiv.org

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Reposted by Elisa Rosati Scalchi

Waggoner Lab @labwaggoner.bsky.social · Mar 17

Direct presentation of endogenous antigen on MHC II is crucial to mRNA-LNP vaccine-induced immune responses
doi.org/10.1101/2025...

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Reposted by Elisa Rosati Scalchi

Waggoner Lab @labwaggoner.bsky.social · Mar 18

42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes
doi.org/10.1002/cyto...

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Reposted by Elisa Rosati Scalchi

Joe Sabatino @jsabatino37.bsky.social · Mar 18

T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis

www.sciencedirect.com/science/arti...

T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Self-peptide-dependent autoproliferation (AP) of B and T cells i…

www.sciencedirect.com

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Reposted by Elisa Rosati Scalchi

Armita Nourmohammad @thearmita.bsky.social · Mar 4

check out our new manuscript (led by Gian Marco Visani):

structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648

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Reposted by Elisa Rosati Scalchi

Jonas N. Søndergaard @jonasns.bsky.social · Feb 20

Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously.
www.nature.com/articles/s41...

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Reposted by Elisa Rosati Scalchi

Science Magazine @science.org · Feb 18

More and more scientists are joining the ranks of fired federal workers—and fighting back through protests, appeals, and legal challenges.

Mass firings decimate U.S. science agencies

White House dismissals and rationale challenged by dismissed scientists and lawsuits

scim.ag

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Reposted by Elisa Rosati Scalchi

Waggoner Lab @labwaggoner.bsky.social · Feb 18

Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease @cp-cellreports.bsky.social
www.cell.com/cell-reports... @anukulshenoy.bsky.social

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