Elisa Rosati Scalchi
@elisarosix.bsky.social
👩🔬 ImmunOmics scientist.
💻 Immune repertoire geek.
🧡 Work at GSK.
💙 IUIS TR-IG NRC committee co-chair.
🐈⬛🍼Mother of 3 (2 cats + 1 human)
🍕 Foodie.
💻 Immune repertoire geek.
🧡 Work at GSK.
💙 IUIS TR-IG NRC committee co-chair.
🐈⬛🍼Mother of 3 (2 cats + 1 human)
🍕 Foodie.
Pinned
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Reposted by Elisa Rosati Scalchi
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 8, 2025 at 1:39 PM
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Reposted by Elisa Rosati Scalchi
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
October 25, 2025 at 6:37 PM
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
Reposted by Elisa Rosati Scalchi
@biorxivpreprint.bsky.social Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 24, 2025 at 7:14 PM
@biorxivpreprint.bsky.social Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Elisa Rosati Scalchi
Integrated epigenetic and genetic programming of primary human T cells - @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @j-eyquem.bsky.social @marsonlab.bsky.social go.nature.com/3WOJJAJ
Integrated epigenetic and genetic programming of primary human T cells - Nature Biotechnology
Multiplexed editing in primary human T cells generates enhanced immune cell therapies.
go.nature.com
October 21, 2025 at 3:57 PM
Integrated epigenetic and genetic programming of primary human T cells - @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @j-eyquem.bsky.social @marsonlab.bsky.social go.nature.com/3WOJJAJ
Reposted by Elisa Rosati Scalchi
Very good 😂. This describes a lot of what is going on accurately.
Credit: @integralanswers.bsky.social
Credit: @integralanswers.bsky.social
October 18, 2025 at 1:30 PM
Very good 😂. This describes a lot of what is going on accurately.
Credit: @integralanswers.bsky.social
Credit: @integralanswers.bsky.social
Reposted by Elisa Rosati Scalchi
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.
www.science.org
October 11, 2025 at 3:11 PM
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Statistics on 100 million people
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
www.nature.com
October 8, 2025 at 6:37 AM
Statistics on 100 million people
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
Reposted by Elisa Rosati Scalchi
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences
The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…
www.sciencedirect.com
August 29, 2025 at 4:49 PM
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
June 28, 2025 at 8:42 AM
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Reposted by Elisa Rosati Scalchi
This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!
We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 9, 2025 at 2:43 PM
This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!
And the second day of #ATCR25 also came to an end. Felt the meeting was a real fresh air of ideas. Super glad I joined. The best part is always to meet with old friends, and the #goodscience of course 😉
I love the location in Antwerp too 😍
I love the location in Antwerp too 😍
May 28, 2025 at 4:28 PM
And the second day of #ATCR25 also came to an end. Felt the meeting was a real fresh air of ideas. Super glad I joined. The best part is always to meet with old friends, and the #goodscience of course 😉
I love the location in Antwerp too 😍
I love the location in Antwerp too 😍
First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
May 27, 2025 at 4:06 PM
First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Reposted by Elisa Rosati Scalchi
Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n
May 2, 2025 at 2:50 PM
Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n
Reposted by Elisa Rosati Scalchi
'Unparalleled' snake antivenom made from man bitten 200 times
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
'Unparalleled' snake antivenom made from man bitten 200 times
Scientists hope to make a universal antivenom from the extraordinary blood of a man exposed to snake venom for decades.
www.bbc.com
May 3, 2025 at 2:59 PM
'Unparalleled' snake antivenom made from man bitten 200 times
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
Reposted by Elisa Rosati Scalchi
New @science.org
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
May 1, 2025 at 6:00 PM
New @science.org
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
Reposted by Elisa Rosati Scalchi
Cool pre-print in my feeds this morning, using a neat trick weighting TCRs by similarity prior to DGE better resolve differential usage. Seems to be a clever trick to make TCRseq behave a little more like regular RNAseq data and better use regular stats/tools:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Differential T cell receptor gene expression analysis using the Wilcoxon test with similarity-based weighting
To better understand immune responses, comparing the abundance of T cell receptors (TCRs) between conditions can provide insights into which T cells have proliferated or were involved in immune activa...
www.biorxiv.org
April 9, 2025 at 3:19 PM
Cool pre-print in my feeds this morning, using a neat trick weighting TCRs by similarity prior to DGE better resolve differential usage. Seems to be a clever trick to make TCRseq behave a little more like regular RNAseq data and better use regular stats/tools:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Elisa Rosati Scalchi
This looks super interesting www.biorxiv.org/content/10.1...
Ultra long-lived plasma cells in the human small intestine produce microbiota-reactive IgA antibodies
A large fraction of the intestinal microbiota is highly coated with secretory IgA, and bacteria-specific IgA is believed to shape the composition of the microbiota. A hallmark of the adaptive immune s...
www.biorxiv.org
March 22, 2025 at 8:54 AM
This looks super interesting www.biorxiv.org/content/10.1...
Reposted by Elisa Rosati Scalchi
Direct presentation of endogenous antigen on MHC II is crucial to mRNA-LNP vaccine-induced immune responses
doi.org/10.1101/2025...
doi.org/10.1101/2025...
March 17, 2025 at 6:48 PM
Direct presentation of endogenous antigen on MHC II is crucial to mRNA-LNP vaccine-induced immune responses
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Elisa Rosati Scalchi
42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes
doi.org/10.1002/cyto...
doi.org/10.1002/cyto...
March 18, 2025 at 4:36 PM
42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes
doi.org/10.1002/cyto...
doi.org/10.1002/cyto...
Reposted by Elisa Rosati Scalchi
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Self-peptide-dependent autoproliferation (AP) of B and T cells i…
www.sciencedirect.com
March 18, 2025 at 5:19 PM
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Elisa Rosati Scalchi
check out our new manuscript (led by Gian Marco Visani):
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
March 4, 2025 at 4:29 AM
check out our new manuscript (led by Gian Marco Visani):
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
Reposted by Elisa Rosati Scalchi
Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 20, 2025 at 10:50 AM
Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Elisa Rosati Scalchi
More and more scientists are joining the ranks of fired federal workers—and fighting back through protests, appeals, and legal challenges.
Mass firings decimate U.S. science agencies
White House dismissals and rationale challenged by dismissed scientists and lawsuits
scim.ag
February 18, 2025 at 11:20 PM
More and more scientists are joining the ranks of fired federal workers—and fighting back through protests, appeals, and legal challenges.