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Scott Coyle

@cellraiser.bsky.social

1.4K followers 570 following 47 posts

signaling systems and protein circuitry. reimagining what cells can be. fun posts only. Assistant Professor: @uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.: @ucsf Wendell Lim @CDI_UCSF

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Scott Coyle @cellraiser.bsky.social · Mar 4

Excited to share a new preprint! Wireless devices use FM modulation to transmit multiplexed noise-resistant data. Led by @born2raisecell.bsky.social, we create a biochemical analogue of this paradigm using genetically encoded oscillators (GEOs) for single-cell FM streaming tinyurl.com/nbs8rw42 🧵

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Akanksha Thawani, PhD @akankshathawani.bsky.social · Aug 19

Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!

We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky

thawanilab.org

The Thawani Lab at Columbia University

The Thawani Lab at Columbia University describing their research on mobile genome, cryo-electron microscopy and genome engineering

thawanilab.org

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Kate Cavanaugh @katecavanaugh.bsky.social · 7d

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 9d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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Boris Sieber @borissieber.bsky.social · 13d

Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!

Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1

doi.org/10.1101/2025...

Schematic of MAPK signalling in fission yeast, budding yeast and Metazoa. No MAPK scaffold was known for ERK-like MAPK in fission yeast, as opposed to budding yeast Ste5 and metazoan KSR1/2.

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Kirsty Wan @micromotility.bsky.social · 14d

Love #protists? Then you'd love this! Beautiful collection of hand-drawn critters represented here at the Oxford-Japan symposium on ethological dynamics in diorama environments sites.google.com/view/oxford-... #ciliates #testateamoeba #diatoms

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Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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John Ngo @johntngo.bsky.social · 16d

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · 18d

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize

Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

www.princeton.edu

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Guillermina Ramirez-SanJuan @guille-rochelle.bsky.social · 20d

Looks like I am late to this party but have exciting news. I’ve been awarded an ERC Starting Grant to study #XtrmCells! Thankful to @erc.europa.eus for this opportunity, and to my collaborators, mentors, and group for their support. Looking forward to exploring the mechanics of these cells!

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Daniel J. Cohen (Princeton) @djcohen.bsky.social · 21d

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

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EMBO @embo.org · 21d

Congratulations to EMBO Young Investigator Uri Ben-David from Tel Aviv University, who has been named one of the 2025 Schmidt Polymaths by @schmidtsciences.bsky.social! 🧪 Uri will study human #aging through the lens of chromosomes.

www.schmidtsciences.org/eight-scient...
#award #genetics #GeneSky

Eight Scientists Named 2025 Schmidt Polymaths to Tackle Breakthroughs in New Disciplines - Schmidt Sciences

Schmidt Sciences announces next cohort of early-to mid- career scientists to each receive up to $2.5 million to pursue novel research. Media Contact: Carlie Wiener, [email protected] NEW…

www.schmidtsciences.org

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Anthony Vecchiarelli @cellforganized.bsky.social · Aug 26

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!

Applications Due by October 15, 2025

We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.

lsa.umich.edu/mcdb/news-ev...

MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)

MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...

lsa.umich.edu

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UW–Madison Department of Biochemistry @uwbiochem.bsky.social · Aug 25

Welcome to Bryce LaFoya, who joins the UW–Madison Department of Biochemistry this month as an assistant professor! Learn more about his research, interests, and lab: biochem.wisc.edu/2025/08/21/n...

New Faculty Profile: Bryce LaFoya

LaFoya, who joined the faculty in August 2025, will study neural stem cells and brain regeneration.

biochem.wisc.edu

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UW–Madison Department of Biochemistry @uwbiochem.bsky.social · Aug 6

Welcome to Wei Wei, who joins the Department of Biochemistry this month as an assistant professor! Learn more about his research, interests, and lab: biochem.wisc.edu/2025/08/05/n...

New Faculty Profile: Wei Wei

Wei, who joined the faculty in August 2025, will explore how what we eat impacts our health.

biochem.wisc.edu

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Jordan Collver @jordancollver.bsky.social · Aug 24

Folks the paper is on the cover of the latest issue of Science.

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Lucien Hinderling @lhinderling.bsky.social · Aug 21

🔬🧠 Our paper on smart microscopy & the issue of interoperability! www.biorxiv.org/content/10.1... LONG THREAD WARNING: Smart microscopy uses real-time image analysis to automatically guide the acquisition or perturbation of the sample (closed feedback-control loop). Many applications exist:

Figure legend: Categories and capabilities of smart microscopy systems integrating real-time image analysis and feedback control. Top: Smart microscopy workflows can be classified based on the driving logic behind decision-making: Event-driven (reacting to rare biological events), Outcome-driven (using feedback-control to steer biological systems toward a desired state), Quality-driven (optimizing signal quality or imaging metrics), and Information-driven (guided by models that predict which measurements/perturbations will yield the most informative data). Middle: Central feedback loop between the microscope and an image analysis system, which continuously
exchanges images and commands to guide acquisition dynamically. Bottom: Key control actions enabled by smart microscopy: adjusting imaging modality (e.g. switching from brightfield to fluorescence, adjusting sampling rate), repositioning the field of view (e.g. tracking, drift correction), optimizing acquisition settings (e.g. adaptive optics),
and performing photomanipulation (e.g. FRAP, ablation, optogenetics).

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Wallace Marshall @wallaceucsf.bsky.social · Aug 19

Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins

www.biorxiv.org/content/10.1...

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Amy Weeks @amyweeks.bsky.social · Aug 13

New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...

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Gautam Dey @gautamdey.bsky.social · Aug 7

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social

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Kirsty Wan @micromotility.bsky.social · Aug 6

We have a postdoc opening for a protistologist with biophysics inclinations to join our @hfspo.bsky.social project! (focus will be on characterising the morphology, ultrastructure and behaviour of excavates) #protistsonsky

Apply by Sept 17th (RTs appreciated!)
jobs.exeter.ac.uk/hrpr_webrecr...

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Hiten Madhani @hitenmadhani.bsky.social · Jul 24

In today's issue of Cell-->if you are looking for a good distraction from the news (who isn't), check it out!
www.cell.com/cell/fulltex...

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology

The construction and high-precision fitness profiling of a C. neoformans knockout library reveals a high-resolution functional map of its genome and allowed for the identification of fungal analogs of...

www.cell.com

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Amy Weeks @amyweeks.bsky.social · Jul 18

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini

Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

rdcu.be

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Kirsty Wan @micromotility.bsky.social · Jul 14

Excited to share that we have received significant funding from the @wellcometrust.bsky.social for a new interdisciplinary consortium project on #cilia coordination and function across scales and organisms! 🎉🥂@lsiexeter.bsky.social

news.exeter.ac.uk/living-syste...

Multi-million project to ‘crack the code’ of cilia – tiny structures with big impact on human health

An international team of researchers, led by the University of Exeter, have been awarded a Wellcome Discovery Award grant of almost £5 million to investigate one of the body’s most fascinating microsc...

news.exeter.ac.uk

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Jul 12

Congrats to Jing @jesszhiyuezhao.bsky.social‬
& @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior

Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...

rdcu.be

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Aaron Whiteley @aaronwhiteley.bsky.social · Jul 12

Our new work understanding how phages are detected by the bacterial immune system is posted on bioRxiv! Check out Toni’s thread for a synopsis👇

toninagy3.bsky.social @toninagy3.bsky.social · Jul 11

I am delighted to share that my work in the @aaronwhiteley.bsky.social lab is now on bioRxiv! We used a large-scale genetic screen to begin defining the vast landscape of phage proteins that trigger immune signaling in bacteria.
www.biorxiv.org/content/10.1...

Identifying phage proteins that activate the bacterial innate immune system

Bacteria have evolved sophisticated antiphage systems that halt phage replication upon detecting specific phage triggers. Identifying phage triggers is crucial to our understanding of immune signaling...

www.biorxiv.org

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