Lightnews — Scholar-powered news

Claire Olingy

@claireolingy.bsky.social

2.1K followers 270 following 23 posts

Senior editor, Science Immunology Based in Washington D.C. Macrophages, dendritic cells, and other myeloid cells; inflammation; immunometabolism; tumor microenvironment https://www.science.org/toc/sciimmunol/current

www.science.org

Posts Media Videos Starter Packs

Pinned

Claire Olingy @claireolingy.bsky.social · Nov 14

Happy to be here with my #ScienceImmunology colleagues!

Seth Thomas Scanlon @immunoeditor.bsky.social · Nov 14

At #ScienceImmunology, I lead a fantastic team of #research #editors comprising Chris Fogg (@cnfogg.bsky.social), Claire Olingy (@claireolingy.bsky.social), and Hannah Isles (@hannah-isles.bsky.social)! Be sure to give them a follow!

www.science.org/journal/scii...

The Science Immunology editors in front of AAAS Headquarters in Washington DC. (L to R): Chris Fogg, Claire Olingy, Seth Thomas Scanlon, & Hannah Isles

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · 9d

David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!

Design of a potent interleukin-21 mimic for cancer immunotherapy

A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

www.science.org

6 43

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · 19d

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Nuclear polarization to the immune synapse facilitates an early transcriptional burst

Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

www.science.org

5 26

Claire Olingy @claireolingy.bsky.social · 27d

Looking forward to a great meeting next week! Email or DM me if you would like to chat!

emds2025.bsky.social @emds2025.bsky.social · 27d

📣 Journal Editors at #EMDS2025

@claireolingy.bsky.social , Senior Editor at #Science #Immunology @aaas.org , will be at EMDS2025, so be sure to reach out to her to discuss your work.

@efis-immunology.bsky.social @britsocimm.bsky.social

1 3

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...

2 7 14

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Jul 4

The July issue of #Science #Immunology is out now! This week:

• Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy!

• Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut!

New content each week!

www.science.org/toc/sciimmun...

Checkpoint on Type 2 Immunity. Tuft cells play key roles in the initiation and propagation of type 2 immune responses in the gut, but whether they have regulatory machinery for constraining these responses is not known. Wang et al. found that the transcription factor Spi-B prevents excessive type 2 immune responses against helminth infection and food allergens by limiting tuft cell activation and proliferation in the small intestine. Spi-B represses c-Kit signaling in tuft cells, which limits their production of the cytokine TSLP and the subsequent activation of T helper 2 (TH2) cells. This month’s cover image features a tuft cell (dark red) within the epithelial lining of the small intestine in which Spi-B has been inactivated, leading to increased production of TSLP by tuft cells and the cytokine interleukin-13 (IL-13) by TH2 cells (white).

Credit: A. Fisher/Science Immunology

1 6 37

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 18

This month in #Science #Immunology, Shivangi Dave & André Ballesteros Tato at the #NIH review the noncanonical contributions of #TFollicularHelper ( #TFH ) cells cells to immune regulation beyond their traditional roles in #BCell help!

science.org/doi/10.1126/sciimmunol.adr1052

Conventional and nonconventional functions of TFH cells: In addition to their conventional role as GC facilitators—providing survival and proliferation signals to GC B cells—TFH cells also perform noncanonical functions. They can support CD8+ T cell responses, produce effector-like cytokines that critically influence B cell fate decisions beyond GC maintenance, and exhibit TSCM properties that allow them to serve as reservoirs for pathogenic Teff cell subsets across various anatomical niches

7 27

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 6

The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost!

New content every week! Check it out!

www.science.org/toc/sciimmun...

ONLINE COVERLNP mRNA Vaccines Get a Boost. Lipid nanoparticle (LNP) mRNA vaccines induce robust immune responses and provide protection against infectious diseases, but this immunity can be short-lived, necessitating frequent booster vaccinations. Aunins et al. investigated how adjuvanting LNP-mRNA vaccines with mRNA encoding the cytokine interleukin-12 (IL-12) influences CD8 T cell responses in mice. Il12 mRNA-LNPs (LNP–IL-12) enhanced antigen-specific CD8 T cell responses and CD8 T cell memory, providing greater protection against bacterial infection and in a mouse model of melanoma. Cytokine-adjuvanted mRNA-LNPs may help future vaccine platforms better tailor the magnitude and nature of the immune response. This month’s cover image features a stylized mRNA-LNP with various lipid (red, coral, and pink) and cholesterol molecules (maroon) encapsulating Il12 mRNA (yellow).

Credit: A. Mastin/Science Immunology

2 13 51

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · May 23

This month in #Science #Immunology: @nickmroz.bsky.social, @phagocyticpai.bsky.social, @annamolofskylab.bsky.social, & @arimolofskylab.bsky.social pen an insightful & timely Review on crosstalk between the #nervous system & #type2 immunity! #WeekendRead

#neuroimmunology #allergy #Alzheimers #itch

Cross-regulation between the nervous system and type 2 immunity

The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.

www.science.org

8 26

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · May 5

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)!

You can submit your abstracts here: iuis2025.org/abstracts/

I hope to see many of you this August in beautiful Vienna!!!

#Immunology #Science2025 #CallForAbstracts #IUIS

Abstracts - IUIS 2025

ABSTRACTS ALL ABOUT SUBMISSION IMPORTANT INFORMATION LATE ABSTRACT SUBMISSION IS NOW OPEN guidelines LATE ABSTRACT SUBMISSION GUIDELINES Important Dates 20 November 2024 – Abstract Submission Opens 25...

iuis2025.org

3 9

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · May 2

The May issue of #Science #Immunology is out now!

This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes!

science.org/toc/sciimmunol/10/107

ONLINE COVER: Lymph Nodes Get a Remodel. Fibroblastic reticular cells (FRCs) are stromal cells that coordinate structural remodeling and adaptive immune responses in the lymph node. Using single-cell transcriptomics and high-resolution microscopy, Lütge et al. comprehensively characterized the stromal cell landscape of human lymph nodes during quiescence and inflammation. Inflammation drove lymph node remodeling including the expansion of peptidase inhibitor 16 (PI16)+ FRCs in macrophage-rich perivascular niches. This month’s cover image shows an inflamed human lymph node that has undergone expansion of podoplanin+ FRCs (purple) near alpha smooth muscle actin (ACTA2)+ vascular smooth muscle cells (green) to support immune cell infiltration and BCL6+ germinal center B cell (orange) activity.

Credit: Lisa Kurz/Kantonsspital St. Gallen

4 26

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Apr 29

Happy Int'l #DayofImmunology! To celebrate, here are some recent Reviews from the pages of #Science #Immunology!!!

First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!

Immunogenomic cancer evolution: A framework to understand cancer immunosuppression

Understanding the impacts of genetic abnormalities on immune responses to tumors can inform immunogenomic-based precision medicine.

www.science.org

2 4 26

Reposted by Claire Olingy

Christiana Fogg @cnfogg.bsky.social · Apr 25

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸
www.science.org/doi/10.1126/...

Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses

Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

www.science.org

1 7

Reposted by Claire Olingy

Science Magazine @science.org · Apr 20

A new #ScienceImmunology study in mice suggests that bacterial skin infections can imprint eosinophils with innate immune memory and enhance allergic inflammation in the lungs.

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation

Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

scim.ag

1 22 62

Reposted by Claire Olingy

Sarah Ross @sarahhross.bsky.social · Apr 11

#Immunology out now @science.org

After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.

buff.ly/49bKcTG

By Jobin, Seetharama, Rüttger et al.

11 39

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Apr 10

The April issue of #Science #Immunology is out now! This past week: two papers describe how #skin #inflammation can drive #type2 immune responses in other #mucosal tissues, while a third describes how #hunger perception in the #brain regulates peripheral immune cell dynamics! Check it out!

Science Magazine @science.org · Apr 9

In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels.

Read about this study and more: scim.ag/4j3gx2A

This month's Science Immunology cover features a hungry dog waiting patiently for a treat.

2 14

Reposted by Claire Olingy

Asma Farhat @asmafarhat.bsky.social · Mar 28

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

www.science.org

3 9 35

Reposted by Claire Olingy

Edelblum Lab @edelblumlab.bsky.social · Mar 22

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

two men are riding a bicycle with a basket on it .

ALT: two men are riding a bicycle with a basket on it .

media.tenor.com

4 16 42

Reposted by Claire Olingy

jie-immunology.bsky.social @jie-immunology.bsky.social · Mar 6

We are thrilled to share our new manuscript @science.org , in which we uncovers a critical role for macrophage peroxisomes in lung repair after viral infection. Could targeting peroxisomes be the key to mitigating long COVID?! www.science.org/doi/10.1126/...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

www.science.org

5 34 110

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Mar 5

To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells!

Check 'em out! They will be available until the end of April!

bit.ly/SciImm_free

#KSmyeloid25

6 21

Reposted by Claire Olingy

Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 28

To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org

The February 2024 cover of Science Immunology depicts CRISPR–Cas9–mediated repair of a dysfunctional cytotoxic T cell (red) from an individual with familial hemophagocytic lymphohistiocytosis (FHL), which allows it to secrete normal cytotoxic granules (pink) and effectively kill virally infected B cells (blue). (Credit: A. Fisher/Science Immunology)

1 14 44

Claire Olingy @claireolingy.bsky.social · Feb 14

This week in #Science #Immunology: A comprehensive review from Darrell Irvine and co-authors on recent advances in understanding #vaccine #adjuvant mechanisms of action, which could guide adjuvant design for vaccines against emerging and challenging pathogens:

Linking vaccine adjuvant mechanisms of action to function

We review mechanisms of action underlying the function of vaccine adjuvants and knowledge gaps to be addressed.

www.science.org

1 9

Reposted by Claire Olingy

Christiana Fogg @cnfogg.bsky.social · Feb 7

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

www.science.org

1 10 32

Claire Olingy @claireolingy.bsky.social · Feb 7

Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma

Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.

www.science.org

4 29

Reposted by Claire Olingy

Claire Olingy @claireolingy.bsky.social · Jan 27

I’ll be here (joint with T cell Differentiation in Tissue Microenvironments) next week! Send me a message or email if you’d like to set up a time to chat. Looking forward to an exciting meeting!

Keystone Symposia @keystonesymposia.bsky.social · Jan 1

Catch @drshrutinaik.bsky.social, @labfairfax.bsky.social, @ostunilab.bsky.social and Yasmine Belkaid for Innate Immune Memory. Submit your abstract for a poster presentation spot by Jan. 9th (11:59pm MST)! keysym.us/KSInnateImmu... #KSInnateImmune25 #keystoneconferences #innateimmunity

3 6