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Reposted by Christiana Fogg

Kilian Schober @kischober.bsky.social · 4d

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

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Reposted by Christiana Fogg

Seth Thomas Scanlon @immunoeditor.bsky.social · 8d

Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!

Inhibitory immune checkpoints in cancer immunotherapy

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

www.science.org

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Christiana Fogg @cnfogg.bsky.social · 29d

That time I was subject of scientific study, and not an editor.....🏃‍♀️🧪

Christie Wilcox @nerdychristie.bsky.social · Aug 29

In this edition of #ScienceAdviser, Science Immunology Senior Editor @cnfogg.bsky.social talks about how her love of running led her to be the subject of science—rather than the editor of it. Plus more of the best from @science.org and science: www.science.org/content/arti... 🧪

Christiana Fogg, 11.7 miles into the 2024 Stone Mill 50-miler. Photo: Dan Reichmann, MCRRC

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Science Magazine @science.org · Aug 13

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd

An illustration depicting the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes.

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Di Jiang @dijiang319.bsky.social · May 17

🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST

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Reposted by Christiana Fogg

Seth Thomas Scanlon @immunoeditor.bsky.social · May 5

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)!

You can submit your abstracts here: iuis2025.org/abstracts/

I hope to see many of you this August in beautiful Vienna!!!

#Immunology #Science2025 #CallForAbstracts #IUIS

Abstracts - IUIS 2025

ABSTRACTS ALL ABOUT SUBMISSION IMPORTANT INFORMATION LATE ABSTRACT SUBMISSION IS NOW OPEN guidelines LATE ABSTRACT SUBMISSION GUIDELINES Important Dates 20 November 2024 – Abstract Submission Opens 25...

iuis2025.org

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Christiana Fogg @cnfogg.bsky.social · Apr 29

Happy World #DayofImmunology!

Seth Thomas Scanlon @immunoeditor.bsky.social · Apr 29

Happy Int'l #DayofImmunology! To celebrate, here are some recent Reviews from the pages of #Science #Immunology!!!

First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!

Immunogenomic cancer evolution: A framework to understand cancer immunosuppression

Understanding the impacts of genetic abnormalities on immune responses to tumors can inform immunogenomic-based precision medicine.

www.science.org

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Christiana Fogg @cnfogg.bsky.social · Apr 25

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸
www.science.org/doi/10.1126/...

Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses

Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

www.science.org

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Reposted by Christiana Fogg

Science Magazine @science.org · Apr 9

In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels.

Read about this study and more: scim.ag/4j3gx2A

This month's Science Immunology cover features a hungry dog waiting patiently for a treat.

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Christiana Fogg @cnfogg.bsky.social · Mar 24

It's #WorldTBDay! Sharing a recent review article in Science Immunology by @tomscriba.bsky.social about our current understanding of the immunopathology of #TB
www.science.org/doi/10.1126/...

Immunopathology in human tuberculosis

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

www.science.org

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Science Magazine @science.org · Mar 17

New research in #ScienceImmunology provides insight into the mechanisms underlying photosensitivity, or ultraviolet light-induced skin inflammation, in certain autoimmune disorders. scim.ag/4iv9kaO

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity

ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.

scim.ag

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Sarah Ross @sarahhross.bsky.social · Mar 14

ICYMI by First release - now in print @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.

buff.ly/3DjNQ1e

By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

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Reposted by Christiana Fogg

Seth Thomas Scanlon @immunoeditor.bsky.social · Mar 7

This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!

Dynamic STING repression orchestrates immune cell development and function

Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

www.science.org

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Christiana Fogg @cnfogg.bsky.social · Mar 7

The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production.
www.science.org/doi/10.1126/...

This month’s cover features a keratinocyte mitochondrion damaged by UVB radiation, which then releases reactive oxygen species (red spheres) and Z-DNA complexed with ZBP1 into the cytoplasm. Image credit: A. Fisher/Science Immunology

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Stella Hurtley @smhsci.bsky.social · Mar 7

Check out the paper below with its related Perspective in @science.org
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

www.science.org

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Reposted by Christiana Fogg

Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 28

This week in #Science #Immunology: researchers @ @uwmadison.bsky.social use #AAV vectors to deliver 2 Abs—one neutralizing #SIV infectivity & killing infected cells via #ADCC & another mediating ADCC but non-neutralizing—to prevent resurgence of SIV replication in #macaques after discontinuing #ART!

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

AAV delivery of antibodies targeting the SIV envelope glycoprotein contains virus replication in macaques after stopping ART.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 15

This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!

TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R–BCL6 signaling nexus

TRAF3 integrates early cell-intrinsic and cell-extrinsic signals to initiate TFH cell differentiation.

www.science.org

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Reposted by Christiana Fogg

Di Jiang @dijiang319.bsky.social · Feb 8

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Protein codes promote selective subcellular compartmentalization

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

www.science.org

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Reposted by Christiana Fogg

Claire Olingy @claireolingy.bsky.social · Feb 7

Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma

Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.

www.science.org

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Christiana Fogg @cnfogg.bsky.social · Feb 7

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

www.science.org

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Reposted by Christiana Fogg

Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 6

Recently in #Science #Immunology: Vidit Bhandakar, Teresa Dinter, & Stefani Spranger from the Koch Institute at @mitofficial.bsky.social have written a terrific #Review on how #DendriticCell signals specify #CD8 #TCell fates in #cancer! #DCs

Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer

DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.

www.science.org

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Reposted by Christiana Fogg

Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 5

This is ... a public ... service ... announcement!

Sarah Ross @sarahhross.bsky.social · Jan 14

If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!

Grand Prize: $25K & your essay published in Science Magazine

Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH

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Reposted by Christiana Fogg

Dan Kaplan @danhkaplan.bsky.social · Jan 30

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation

Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

www.science.org

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Hannah Isles @hannah-isles.bsky.social · Jan 27

In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.

Human naïve B cells recognize prepandemic influenza virus hemagglutinins

Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

www.science.org

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