Lightnews — Scholar-powered news

Reposted by Franziska Auer

Mick Milsom @milsommick.bsky.social · 12d

Part 2 of the joint EHA/ISEH session at #ISEH2025 Kumamoto: Zuzana Tothova on therapeutic targeting of cohesin-mutant myeloid malignancies @isehsociety.bsky.social

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Nature Reviews Genetics @natrevgenet.nature.com · Jul 29

New online! Methods and applications of in vivo CRISPR screening

Methods and applications of in vivo CRISPR screening

Nature Reviews Genetics, Published online: 29 July 2025; doi:10.1038/s41576-025-00873-8In vivo CRISPR screens generate high-throughput, unbiased genotype–phenotypes maps for complex biological processes that cannot be studied in vitro. This Review outlines key criteria for understanding, designing and implementing such screens and discusses their potential impact on basic and translational research.

www.nature.com

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Moritz Gerstung @moritzgerstung.bsky.social · Jul 29

This is a great set of methods for studying combinatorial effects of cancer mutations on spatial phenotypes.

Clever experimental design by @breinigmarco.bsky.social hijacking Visium and elegant analysis by @lomakinai.bsky.social and @elihei.bsky.social

www.nature.com/articles/s41...

Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships - Nature Biomedical Engineering

A method integrates perturbation mapping with 10X Visium spatial transcriptomics to map tumour genetic complexity and heterogeneity.

www.nature.com

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NEJM.org @nejm.org · Jun 25

In a new article on measles, the authors review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies. Read the full article: nej.md/4lmC1Ir

#MedSky @lshtm.bsky.social

Panels A–C: Features of measles including Koplik spots on the buccal mucosa; rash on the trunk, spreading to the face, head, arms, and legs; and conjunctivitis.

Panel D: A timeline of the pathogenesis of measles.

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Franziska Auer @franziskaauer.bsky.social · Jun 14

Make sure not to miss the last #YERM Session on „New frontiers in preclinical development of cellular therapies and other immunotherapies“ at 15.45 pm. #EHA2025 #Hematology

Interested in actively participating in YERM next year? Check out the link below!

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HemaSphere Journal @hemasphere-journal.bsky.social · Jun 14

🚨Today! @ 15:45, MiCo room CORAL 6
We warmly invite you to the HemaSphere Scientific Session where we will dive into 3 of our exciting + cutting-edge biology publications. Hope to see you there!
🕰️: 15:45 - 16:45
📍: Room CORAL 6, #EHA2025
🎤: https://bit.ly/4koLwXk

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Marlies Vanden Bempt @marliesvandenbempt.bsky.social · Jun 14

A big thank you to all the speakers in session 2 of #YERM ! See you this afternoon for session 3 on cellular plasticity #youngEHA #EHA2025

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Franziska Auer @franziskaauer.bsky.social · Jun 14

Don’t miss the second YERM Session on „New insights into clonal hematopoiesis“ at 10 o‘clock in Brown Hall 2!
#EHA2025 #YoungEHA #Hematology

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Franziska Auer @franziskaauer.bsky.social · Jun 14

If you're attending #EHA2025, make sure you don't miss the #YoungEHA Research Meeting (YERM) today. It starts off with an exciting session on "Erythropoiesis: From biology to pathology" at 8 o'clock in the Brown Hall 2!

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Oliver Cornely @olivercornely.bsky.social · Jun 10

🎉 Congratulations to Jon Salmanton-García on his appointment to the Young EHA Committee, representing Germany!
A well-earned recognition of his dedication and expertise in hematology.
Looking forward to the fresh perspectives he'll bring.
#YoungEHA #Hematology #EHA2025 #Germany

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STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · May 17

BCG revaccination failed to protect HIV-negative adolescents from sustained QFT test conversion and caused more adverse reactions.

by Schmidt AC, Fairlie L (...) Hatherill M et 13 al. in N Engl J Med #MedSky

👉 get more here

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2412381

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ProteoCure @proteocure.bsky.social · Apr 29

Free online AlphaFold training on May 7, thanks to Fabian Glaser, Salomé Llabrés & Rune Matthiesen!

They'll start from the very basics & explore how this powerful tool is reshaping protein science.

Register here (required): forms.office.com/e/Hg3fe2Depm
Open to all, feel free to share!

#AlphaFold

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bioRxiv Genetics @biorxiv-genetic.bsky.social · Apr 30

Mutational signature catalogue (MUSIC) of DNA double-strand break repair https://www.biorxiv.org/content/10.1101/2025.04.29.650617v1

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Eric Topol @erictopol.bsky.social · Apr 9

A high polygenic risk score (PRS) for screening prostate cancer was superior to a PSA test or MRI for detecting clinically significant disease (Gleason ≥7). A big step forward for supporting utility of PRS @nejm.org
www.nejm.org/doi/full/10....

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer | NEJM

The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...

www.nejm.org

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Waggoner Lab @labwaggoner.bsky.social · Apr 3

Review @cp-trendsimmuno.bsky.social @ostunilab.bsky.social
IL-1β+ macrophages and the control of pathogenic inflammation in cancer
www.cell.com/trends/immun...

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alba-maiques.bsky.social @alba-maiques.bsky.social · Apr 2

Once more, exciting times ahead for young_eha 🌱

It was great to finally meet in person all new members & have time to discuss all the projects.

Specially excited with the kick-off of the mentorship program at the Congress 👏

📢 We have one vacancy, application is open!

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Djoser Genomics @djosergenomics.github.io · Mar 31

Another Great Youtube Tutorials by Biostatsquid

GSEA Explanation
youtu.be/egO7Lt92gDY?...

GSEA Interpretation
youtu.be/Yi4d7JIlAsM?...

Gene Set Enrichment Analysis (GSEA) – simply explained!

YouTube video by Biostatsquid

youtu.be

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Hannah Peckham (she/her) @hlpeks.bsky.social · Mar 25

Thrilled to finally share our paper on how sex hormones and sex chromosomes interact to affect B cell class-switching!🥳 Diversity & inclusion in research recruitment = better science for all!😎 Thanks to @bcellsrosser.bsky.social@[email protected] for ++ hard work!🌟

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes | Journal of Experimental Medicine | Rockefeller University Press

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in ind

rupress.org

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Scott McGrath @smcgrath.phd · Mar 26

🧪 AI-written peer reviews are quietly reshaping science. Despite bans, reviewers are using LLMs to draft critiques, raising fears about shallow analysis, lost peer insight, and the erosion of trust. As @carlbergstrom.com states in the piece "Writing is thinking."
#AcademicSky

AI is transforming peer review — and many scientists are worried

Artificial intelligence software is increasingly involved in reviewing papers, provoking interest and unease.

www.nature.com

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Kilian Schober @kischober.bsky.social · Mar 26

Es war mir eine Ehre und Freude, einen Teil beizutragen.

Bayerische Akademie der Wissenschaften (BAdW) @badw.de · Mar 26

Die erste Folge ist da! 🥳

#Krebs besiegen: Folge 1 - Bilder und Zellen

🎧 badw.de/die-akademie...

Die weiteren Folgen erscheinen im 2-Wochen-Rhythmus.

#Krebsmedizin #Krebsforschung #Brustkrebs #Leukämie #Krebsdiagnostik

Zwei Menschen schieben einen roten Tumor über eine Klippe. Text: Krebs besiegen. Eine Podcast-Dokumentation in vier Teilen

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Eric Topol @erictopol.bsky.social · Mar 26

Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

www.nature.com

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bioRxivpreprint @biorxivpreprint.bsky.social · Mar 18

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress https://www.biorxiv.org/content/10.1101/2025.03.17.643278v1

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Jay 🦋 @jay.bsky.team · Mar 13

Bluesky is the place for science.

Altmetric @altmetric.com · Mar 13

Mike spotted this before the rest of us. 🫡

Publications from 2025 are shared more on Bluesky than on X/Twitter.

herrison2000.bsky.social @herrison2000.bsky.social · Mar 13

About to talk to medical affairs colleagues, with the news that Bluesky is carrying more posts about new journal publications than X #bluesky #altmetrics #x #xparrot

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Haley Lab @labohaley.bsky.social · Mar 17

A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...

Healing My Family’s Future

How genetics and IVF empowered a family to leave cancer behind.

press.asimov.com

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bioRxivpreprint @biorxivpreprint.bsky.social · Mar 17

Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex https://www.biorxiv.org/content/10.1101/2025.03.14.643254v1

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