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Yogesh Goyal @goyallab.bsky.social · 19d

**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT

Goyal Lab

www.goyallab.org

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Julius Brennecke @juliusbrennecke.bsky.social · 20d

Love RNA biology?

Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).

PhD student/postdoc position co-supervised by Clemens Plaschka & myself.

DM or email us if you’d like to know more!

@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

Julius Brennecke @juliusbrennecke.bsky.social · 21d

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.

But how does piRNA-guided target interaction translate into silencing?

PhD student Júlia Portell Montserrat has an intriguing answer

www.cell.com/molecular-ce...

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John Doench @johndoench.bsky.social · Sep 7

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

Balancing off-target and on-target considerations for optimized Cas9 CRISPR knockout library design

The continued development of high-dimensional CRISPR screen readouts, such as single-cell RNA sequencing and high-content imaging, necessitates compact libraries to enable functional interrogation at ...

www.biorxiv.org

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Daniel Durocher @durocher1.bsky.social · Aug 28

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

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Karolinska Institutet @ki.se · Aug 18

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

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Thomas Norman @normanlab.bsky.social · Aug 6

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

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IRB Barcelona @irbbarcelona.org · Aug 5

🧪 Registrations open for the #BarcelonaBiomed conference "When Development Meets #Cancer: Origins, Models & Therapies in #ChildhoodCancer."

Organised by Dr. Alexandra Avgustinova, Dr. Cayetano González (@irbbarcelona.org) & Dr. Jaume Mora (@sjdhospitalbarcelona.org)

➡️ https://f.mtr.cool/hpdbcpiant

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Glen Pyle | Womens Heart Health ❤️‍🩹🖇️ @glenpyle.bsky.social · Jul 31

📣Faculty Position Opening!

👩🏾‍🔬An exciting opportunity for an Assistant Professor position in aging research at @UMontreal

🗓️Application deadline 15 September

#FacultyJobs #CdnSci #Research #Aging

medicinoxy.com/assistant-pr...

Assistant Professor in Aging (University of Montreal)

medicinoxy.com

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Eileen Furlong @eileen-furlong.bsky.social · Jul 30

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader - Genome Biology Unit

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

embl.wd103.myworkdayjobs.com

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Julius Brennecke @juliusbrennecke.bsky.social · Jul 29

last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

EMBL Events @events.embl.org · Jun 18

⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome

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Haley Lab @labohaley.bsky.social · Jul 24

New preprint that we're super excited to share! With @ceo.onjcri.org.au and colleagues @wehi-research.bsky.social and @ONJCRI, along with teams @Genentech, we developed + demonstrate the use of Partita, a new suite of CRISPRa libraries for murine model systems.

www.biorxiv.org/content/10.1...

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

CRISPR activation (CRISPRa) enables precise, locus-specific upregulation of gene expression, offering potential for both ex vivo and in vivo applications. However, the lack of scalable, high-coverage ...

www.biorxiv.org

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Alex Rubinsteyn @alexr.bsky.social · Jul 23

Going deep on 2A peptides:

www.cell.com/cell-reports...

(Trying to pick between GSG:T2A, GSG:P2A, and furin site:GSG:T2A)

Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences

Rao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who...

www.cell.com

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Innovative Genomics Institute @innovativegenomics.bsky.social · Jul 17

We’re thrilled to announce IGI–Bakar Labs. This new building will allow the IGI to continue expanding our impact in health and agricultural applications of #CRISPR, and will be shared with the Bakar Labs incubator for growing biotech companies. Learn more: news.berkeley.edu/2025/07/17/c...

CRISPR researchers and startup entrepreneurs will share new building in UC Berkeley's Innovation Zone - Berkeley News

A planned addition to the campus's Innovation Zone will expand lab space for the Innovative Genomics Institute and build out the largest innovation hub — Bakar Labs — at any U.S. university.

news.berkeley.edu

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bioRxiv Genomics @biorxiv-genomic.bsky.social · Jul 17

Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response https://www.biorxiv.org/content/10.1101/2025.07.14.664827v1

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Yogesh Goyal @goyallab.bsky.social · Jul 6

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications
shorturl.at/2LHbw

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Ben Martin @benjaminmartin.bsky.social · Jul 1

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Assistant Professor (Research), Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research (C1-250514)

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

mcgill.wd3.myworkdayjobs.com

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Lindsay K Pino @lindsaykpino.com · Jul 2

Here we go, my first skeet-torial(?) on Bluesky for my first paper from @talusbio.bsky.social !

www.biorxiv.org/content/10.1...

This preprint describes our scalable, mass spec-based method for measuring which (and how many of them) proteins are interacting with DNA.

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Native, Spatiotemporal Profiling of the Global Human Regulome

The regulome, comprising transcription factors, cofactors, chromatin remodelers, and other regulatory proteins, forms the core machinery by which cells interpret signals and execute gene expression pr...

www.biorxiv.org

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Tugce Aktas @aktast.bsky.social · Jun 30

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology

Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

www.nature.com

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Haley Lab @labohaley.bsky.social · Jun 30

Now in @natcomms.nature.com‬! Our work on the molecular mechanisms of gymnosis & its relevance to ASO/oligo therapeutics. An amazing collaboration with F. Roudnicky, L. Malong, A. Spang & more. Thanks to the editor/reviewers for their thoughtful feedback. www.nature.com/articles/s41...

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity - Nature Communications

Antisense oligonucleotide (ASO) cellular activity requires endosomal escape. Here, the authors show that disrupting Golgi-endosome protein AP1M1 enhances ASO activity by prolonging ASO endosomal resid...

www.nature.com

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Anne Carpenter @drannecarpenter.bsky.social · Jun 24

Broad's Machine Learning in Drug Discovery Symposium coming soon! Nov 7, 2025. Another great lineup.

In person (Cambridge MA) and online options

Register by July 4 for a discount

www.broadinstitute.org/machine-lear...

Speakers

Speakers at the 2025 Machine Learning in Drug Discovery Symposium: Tom Miller Iambic Therapeutics Ava Amini Microsoft Research Project Ex Vivo Francesca Grisoni Eindhoven University of Technology Ore...

www.broadinstitute.org

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Mike Feigin 🥯 @mikefeigin.bsky.social · Jun 5

Here is the official posting for a faculty job in Pharmacology and Therapeutics at Roswell Park Comprehensive Cancer Center! Feel free to DM or email with questions.
roswellpark.wd5.myworkdayjobs.com/en-US/Ext-RP...

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Soragni:Lab @alice.soragnilab.com · Jun 3

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies
www.nature.com/articles/s41...

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer

Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

www.nature.com

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Haley Lab @labohaley.bsky.social · Jun 1

Cool stuff re: plasmid chromatinization from the Stergachis Lab (not on Bluesky?). As they note in the discussion, it would be interesting to apply this to other extra-chromosomal contexts like AAV and the ecDNA found in some tumor cells.

www.biorxiv.org/content/10.1...

Principles and functional consequences of plasmid chromatinization in mammalian cells

Plasmids have fundamentally transformed how we resolve regulatory grammar across the tree of life. However, although chromatin plays an integral role in regulating the function of regulatory elements ...

www.biorxiv.org

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Noelia Ferruz @noeliaferruz.bsky.social · May 23

@isabellease.bsky.social is drawing amazing artwork for each speaker at #VariantEffect25 - crazy beautiful and super good summaries in all cases, have a look🤯

Isabelle Zane @isabellease.bsky.social · May 22

@juliadiumenge.bsky.social at #VariantEffect25

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Stein Aerts @steinaerts.bsky.social · May 21

One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...

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