banner
georgeefinney.bsky.social
George Finney
@georgeefinney.bsky.social
1K followers 420 following 24 posts
Post-doc @pallettlab.bsky.social, Institute of Immunity and Transplantation, UCL • investigating stromal-T cell communication in liver fibrosis • he/him • #immunology
Posts Media Videos Starter Packs
georgeefinney.bsky.social
George Finney @georgeefinney.bsky.social · 5h
Too right! #TeamStroma
1
Reposted by George Finney
britsocimm.bsky.social
British Society for Immunology @britsocimm.bsky.social · 12h
Our iconic immune cell badges are back for #BSI25, and you get to choose the next design! 🎨🧫

Vote now and help decide which badge will join the line-up in Liverpool 👇

Cast your vote here🔗: https://bit.ly/46DtHzy
4 14
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 1d
Pre-division TCF1 drop determines long-term CD8 T cell fates @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
5 6
Reposted by George Finney
boghuma.bsky.social
BK. Titanji @boghuma.bsky.social · 2d
Without an understanding of immune tolerance, organ transplantation will not be possible. Also, their discoveries opened avenues for cancer and auto immune disease therapies.
Congratulations to these year's awardees of the nobel prize in physiology or medicine.
bit.ly/4mC0Gc5
4 37 120
Reposted by George Finney
natimmunol.nature.com
natimmunol.nature.com @natimmunol.nature.com · 2d
Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation
6 19
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 7d
Review @natrevimmunol.nature.com
Regulators of CD8+ T cell exhaustion
www.nature.com/articles/s41...
3 17
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 16d
Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
2 9
georgeefinney.bsky.social
George Finney @georgeefinney.bsky.social · 16d
🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈

Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
natrevgastrohep.nature.com
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 16d
New online! Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01118-zThis Review provides a comprehensive overview of the role of tissue-resident memory CD8+ T cells in hepatic immune responses, explores their dual function in liver immunoprotection and immunopathology, and discusses their therapeutic potential.
www.nature.com
3 9
Reposted by George Finney
immunoeditor.bsky.social
Seth Thomas Scanlon @immunoeditor.bsky.social · 19d
Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!
Nuclear polarization to the immune synapse facilitates an early transcriptional burst
Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.
www.science.org
5 26
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 22d
A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection @jclinical-invest.bsky.social @nationwidekids.bsky.social
www.jci.org/articles/vie...
1 3 5
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 21d
Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset @biorxivpreprint.bsky.social @nidcr.bsky.social #NCI www.biorxiv.org/content/10.1...
2 7
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23d
CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social
www.cell.com/immunity/ful...
3 8
Reposted by George Finney
mucosalimmunol.bsky.social
Mucosal Immunology @mucosalimmunol.bsky.social · 28d
T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors www.mucosalimmunology.org/article/S193...
2 2
Reposted by George Finney
rupress.org
Rockefeller University Press @rupress.org · Sep 4
In @jem.org, Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...
1 2
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Sep 6
CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social
academic.oup.com/jimmunol/adv...
4 11
Reposted by George Finney
pallettlab.bsky.social
Pallett Lab UCL @pallettlab.bsky.social · Sep 5
Fantastic to see this out 👏

ScRNAseq data from 77 patients as an atlas for all to use. Used to identify a new subpopulation of pro-inflammatory scar-associated macrophages which promote fibrosis from our friends in the Ramachandran lab. 🧪 #liversky #immunosky

www.biorxiv.org/content/10.1...
A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver Disease
Chronic liver disease (CLD) is a major global healthcare problem. Irrespective of cause, chronic damage to the liver results in fibrosis, which is associated with adverse clinical outcomes. Immune cel...
www.biorxiv.org
1 9
Reposted by George Finney
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Aug 29
Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis @natimmunol.nature.com
www.nature.com/articles/s41...
2 9
Reposted by George Finney
payalyokota.bsky.social
Payal Yokota @payalyokota.bsky.social · Aug 29
Absolutely brilliant review #Freshoffthepress

www.nature.com/articles/s41...

#CD8Tcelldysfunction
The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology
Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...
www.nature.com
1 5
georgeefinney.bsky.social
George Finney @georgeefinney.bsky.social · Aug 29
Just submitted my abstract to #BSI25, so excited to head up to Liverpool for another Congress!

Who else is travelling to the north west? 🤩
britsocimm.bsky.social
British Society for Immunology @britsocimm.bsky.social · Aug 29
There isn't long left to submit your abstract for #BSI25!

This is your chance to present your research at the UK's flagship immunology event. Don't miss out!

🗓️Deadline: Weds 3 Sept
🔗Submit here: bit.ly/3UfF6i5
7
Reposted by George Finney
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · Aug 28
One more diabolical trick of cancer cells: transferring their mitochondria to fibroblasts to promote their growth
nature.com/articles/s43...
Cancer-derived mitochondria fuel fibroblasts to become pro-tumorigenic - Nature Cancer
Cancer-associated fibroblasts represent a functionally diverse and heterogeneous entity within the solid tumor microenvironment. Mitochondrial transfer from cancer cells to fibroblasts is now shown to...
nature.com
6 44 130
Reposted by George Finney
britsocimm.bsky.social
British Society for Immunology @britsocimm.bsky.social · Aug 28
Building a professional network can have a big impact, but attending meetings isn't always easy.

The BSI Career Enhancing Grant can help with the costs of joining networking events and connecting with peers.

Find out more & apply by 24 September: https://bit.ly/3QedNDL
3 2
Reposted by George Finney
franzeprogatzky.bsky.social
Fränze Progatzky @franzeprogatzky.bsky.social · Aug 27
In case you missed it: @juliakarjalainen.bsky.social co-authored this recent review with our lab on glia in barrier organs in @mucosalimmunol.bsky.social We summarise cutting-edge findings and highlight future directions for the field - timely reading: www.mucosalimmunology.org/article/S193...
Glial-immune interactions in barrier organs
Neuro-immune interactions within barrier organs, such as lung, gut, and skin, are crucial in regulating tissue homeostasis, inflammatory responses, and host defence. Our rapidly advancing understandin...
www.mucosalimmunology.org
3 2
Reposted by George Finney
linterman.bsky.social
Michelle Linterman @linterman.bsky.social · Aug 27
Beautiful talk from @mahimaswamy.bsky.social at #EMBObarrierTissues. Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes | bioRxiv share.google/UroEHTZJI7tk...
Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes
Natural intraepithelial T lymphocytes (T-IELs) are innate-like, intestine-resident T cells essential for gut homeostasis. These cells express self-reactive T cell antigen receptors (TCRs) due to thymi...
share.google
2 14
Reposted by George Finney
yefis-immunology.bsky.social
yEFIS @yefis-immunology.bsky.social · Aug 25
👶✈️ Balancing caregiving and academic travel?

Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving"

🗓️ Sept 25 | 🕒15:00 CEST
🔗https://tinyurl.com/yefis2025-ia2

Hosted by the Improving Academia group of yEFIS
1 10 9
georgeefinney.bsky.social
George Finney @georgeefinney.bsky.social · Aug 22
Safe to say #IUIS2025 was a blast! A packed and wonderful programme, seeing old friends and new, an immunology run and one hell of a congress party 🎉

What more could you ask for? Here’s to #IUIS2028 in Toronto 🇨🇦
1 8