Ghanendra Singh
@ghanendra.bsky.social
Computational Glioscientist. PhD student at Institute of Neural Engineering @TU Graz.
Decoding Astrocytic Leaky-Blood Brain Barrier #(BBB). Research Interests in astrocytes, working memory, aging and neuromorphic devices.
Decoding Astrocytic Leaky-Blood Brain Barrier #(BBB). Research Interests in astrocytes, working memory, aging and neuromorphic devices.
Pinned
24 - Ghanendra Singh (TU Graz, Austria) - Late breaking news
YouTube video by Neuro Inspired Computational Elements Conference
www.youtube.com
An earlier late breaking news talk on switching dynamics in working memory model showing complex MMOs proposed for efficient WM hardware implementation using SNNs in March at NICE 2025.
www.youtube.com/watch?v=zVDu...
www.youtube.com/watch?v=zVDu...
Reposted by Ghanendra Singh
New results! Computational models often rely on hand-crafted connectivity and imposed dynamics to produce traveling waves (TWs). We show how TWs can naturally emerge under biologically plausible conditions.
Emergent Traveling Waves in Neural Circuits
doi.org/10.64898/202...
#neuroscience
Emergent Traveling Waves in Neural Circuits
doi.org/10.64898/202...
#neuroscience
Emergent Traveling Waves in Neural Circuits
Artificial neural networks achieve striking performance but do not capture a prominent neural property. Cortical activity is organized by structured spatiotemporal dynamics, traveling waves (TW), whic...
doi.org
January 9, 2026 at 12:32 PM
New results! Computational models often rely on hand-crafted connectivity and imposed dynamics to produce traveling waves (TWs). We show how TWs can naturally emerge under biologically plausible conditions.
Emergent Traveling Waves in Neural Circuits
doi.org/10.64898/202...
#neuroscience
Emergent Traveling Waves in Neural Circuits
doi.org/10.64898/202...
#neuroscience
Reposted by Ghanendra Singh
Many cortical traveling waves spiral. Here's how and why.
Cortical Field Model of Complex Spiral Traveling Waves
doi.org/10.64898/202...
#neuroscience
Cortical Field Model of Complex Spiral Traveling Waves
doi.org/10.64898/202...
#neuroscience
Cortical Field Model of Complex Spiral Traveling Waves
Complex spiral traveling waves observed experimentally occurs across the cortex. The underlying mechanisms responsible for generating such mesoscopic activity are not well understood. Understanding ho...
doi.org
January 9, 2026 at 12:37 PM
Many cortical traveling waves spiral. Here's how and why.
Cortical Field Model of Complex Spiral Traveling Waves
doi.org/10.64898/202...
#neuroscience
Cortical Field Model of Complex Spiral Traveling Waves
doi.org/10.64898/202...
#neuroscience
Wow !! Another RNN based #TravelingWave #TW mechanistic model for cortical computation.
In future: 🌊 Prop > 🔙 Prop 🤩.
In future: 🌊 Prop > 🔙 Prop 🤩.
Emergent Traveling Waves in Neural Circuits https://www.biorxiv.org/content/10.64898/2026.01.08.698281v1
January 9, 2026 at 11:43 AM
Wow !! Another RNN based #TravelingWave #TW mechanistic model for cortical computation.
In future: 🌊 Prop > 🔙 Prop 🤩.
In future: 🌊 Prop > 🔙 Prop 🤩.
Reposted by Ghanendra Singh
Delighted to share our first preprint of the year!
A project that we're all really proud of in the lab led by @ossamaghenissa.bsky.social with @mathiasgua.bsky.social in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour.
www.biorxiv.org/content/10.6...
A project that we're all really proud of in the lab led by @ossamaghenissa.bsky.social with @mathiasgua.bsky.social in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour.
www.biorxiv.org/content/10.6...
Astrocytic Encoding of Threat in the Basolateral Amygdala
The basolateral amygdala (BLA) has long been implicated in threat detection and the generation of anxiety states. While previous experiments have demonstrated the important role of BLA principal neuro...
www.biorxiv.org
January 8, 2026 at 7:58 PM
Delighted to share our first preprint of the year!
A project that we're all really proud of in the lab led by @ossamaghenissa.bsky.social with @mathiasgua.bsky.social in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour.
www.biorxiv.org/content/10.6...
A project that we're all really proud of in the lab led by @ossamaghenissa.bsky.social with @mathiasgua.bsky.social in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour.
www.biorxiv.org/content/10.6...
Reposted by Ghanendra Singh
RMAAT: Astrocyte-Inspired Memory Compression and Replay for Efficient Long-Context Transformers
https://arxiv.org/abs/2601.00426
https://arxiv.org/abs/2601.00426
January 6, 2026 at 4:39 AM
RMAAT: Astrocyte-Inspired Memory Compression and Replay for Efficient Long-Context Transformers
https://arxiv.org/abs/2601.00426
https://arxiv.org/abs/2601.00426
Beautiful 🤩 !! Function as CIM.
In this mesmerizing video by our #ElectronMicroscopy team, a layer 5 thin tufted neuron is revealed with blue dendrites and purple axon. As it progresses, we zoom into where it connects to a pyramidal cell.
Explore our EM data at: microns-explorer.org
Explore our EM data at: microns-explorer.org
January 8, 2026 at 7:46 PM
Beautiful 🤩 !! Function as CIM.
Complex #spiral #traveling-waves across the cortex.
January 8, 2026 at 7:44 PM
Complex #spiral #traveling-waves across the cortex.
Modeling endfeet aging of BBB in PFC might give us interesting insights.
Happy to share the video Isabel Bravo-Ferrer and Katrine Gaasdal-Bech made to summarize the findings of our manuscript in Brain Communications (academic.oup.com/braincomms/a...) Age-dependent regional differences in features of the brain vasculature, including endfeet 💙!
youtu.be/mwgh_H1mcLI?...
youtu.be/mwgh_H1mcLI?...
Blood-brain barrier phenotyping shows prefrontal cortex most vulnerable to ageing in mice
YouTube video by BRAIN Journals
youtu.be
January 8, 2026 at 1:47 PM
Modeling endfeet aging of BBB in PFC might give us interesting insights.
MERCs in astrocytic brain aging.
New review out today in Open Biology, a Royal Society publication on mitochondria-ER contacts and their potential use as therapeutic targets. doi.org/10.1098/rsob... @keavneylab.bsky.social @thebhf.bsky.social @official-uom.bsky.social @gensocuk.bsky.social
The fundamental role of mitochondria–endoplasmic reticulum contacts in ageing and declining healthspan | Open Biology
This open question research article highlights mitochondria-associated endoplasmic
reticulum (ER) membranes (MAMs), which have emerged as crucial cellular structures
that challenge our traditional und...
doi.org
January 8, 2026 at 1:29 PM
MERCs in astrocytic brain aging.
Reposted by Ghanendra Singh
Mitochondrial transfer from satellite glial cells (SGC) to neurons protects against peripheral neuropathy; SGCs are capable of transferring mitochondria to dorsal root ganglia sensory neurons in vitro, ex vivo & in vivo (via tunnelling nanotubes)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 8, 2026 at 9:11 AM
Mitochondrial transfer from satellite glial cells (SGC) to neurons protects against peripheral neuropathy; SGCs are capable of transferring mitochondria to dorsal root ganglia sensory neurons in vitro, ex vivo & in vivo (via tunnelling nanotubes)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ghanendra Singh
Happy new year everyone 🍾 To start the year we have a new webinar coming soon! Prof. Bo Peng from the Institute for Translational Brain Research in China will be our next speaker on January 13th. Check all the information in the flyer and add it to your calendar! 🧬🧠
January 8, 2026 at 9:55 AM
Happy new year everyone 🍾 To start the year we have a new webinar coming soon! Prof. Bo Peng from the Institute for Translational Brain Research in China will be our next speaker on January 13th. Check all the information in the flyer and add it to your calendar! 🧬🧠
Possibly a significant role in the Long Term WM based dynamics.
Traveling waves. Your brain has them for a reason.
Dynamical Mechanisms for Coordinating Long-term Working Memory Based on the Precision of Spike-timing in Cortical Neurons
arxiv.org/abs/2512.15891
#neuroscience
Dynamical Mechanisms for Coordinating Long-term Working Memory Based on the Precision of Spike-timing in Cortical Neurons
arxiv.org/abs/2512.15891
#neuroscience
Dynamical Mechanisms for Coordinating Long-term Working Memory Based on the Precision of Spike-timing in Cortical Neurons
In the last century, most sensorimotor studies of cortical neurons relied on average firing rates. Rate coding is efficient for fast sensorimotor processing that occurs within a few seconds. Much less...
arxiv.org
January 7, 2026 at 3:40 PM
Possibly a significant role in the Long Term WM based dynamics.
True, an interesting way of looking at the brain computing dynamics.
Rotating brain waves keep your thoughts on track
picower.mit.edu/news/after-d...
@picowerinstitute.bsky.social #neuroscience
picower.mit.edu/news/after-d...
@picowerinstitute.bsky.social #neuroscience
After distractions, rotating brain waves may help thought circle back to the task
To get back on track after a distraction, the cortex appears to employ a rotating traveling wave, a new study by MIT neuroscientists finds.
picower.mit.edu
January 7, 2026 at 3:39 PM
True, an interesting way of looking at the brain computing dynamics.
Beauty of #spiral-waves even in the fertilized eggs 🤩 ComplexSystems dynamics !!
news.mit.edu/2020/growth-...
news.mit.edu/2020/growth-...
The growth of an organism rides on a pattern of waves
An MIT study finds waves that ripple across a newly fertilized egg are similar to the waves in seemingly unrelated systems, from ocean and atmospheric circulations to quantum fluids.
news.mit.edu
January 7, 2026 at 3:34 PM
Beauty of #spiral-waves even in the fertilized eggs 🤩 ComplexSystems dynamics !!
news.mit.edu/2020/growth-...
news.mit.edu/2020/growth-...
Astrocytes with slow and fast calcium dynamics seen from reinforcement learning framework. 2026 💥
Multitimescale Computation by Astrocytes https://www.biorxiv.org/content/10.64898/2026.01.05.697758v1
January 6, 2026 at 8:23 AM
Astrocytes with slow and fast calcium dynamics seen from reinforcement learning framework. 2026 💥
Now What? 🔖
"Choosing problems is the primary determinant of what one accomplishes in science."
'Now What?' by Nobel Laureate John Hopfield should be required reading for aspiring scientists.
pni.princeton.edu/document/1136
'Now What?' by Nobel Laureate John Hopfield should be required reading for aspiring scientists.
pni.princeton.edu/document/1136
January 5, 2026 at 10:21 PM
Now What? 🔖
Reposted by Ghanendra Singh
Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation https://www.biorxiv.org/content/10.64898/2026.01.02.697363v1
January 3, 2026 at 2:15 AM
Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation https://www.biorxiv.org/content/10.64898/2026.01.02.697363v1
Astrocytic Engrams !! 🤩
Astroengrams: rethinking the cellular substrate for memory — a Perspective by Javier Sánchez Romero & Marta Navarrete
#neuroscience #neuroskyence
www.nature.com/articles/s41...
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Astroengrams: rethinking the cellular substrate for memory - Nature Reviews Neuroscience
Recent evidence suggests that astrocytes, through coordinated activation in sparse ensembles, contribute to memory traces — termed ‘astro-neuronal engrams’. In this Perspective, Sánchez Romero and Nav...
www.nature.com
January 5, 2026 at 8:51 PM
Astrocytic Engrams !! 🤩
Reposted by Ghanendra Singh
📢 Registration for our second UK Glia meeting (8–9 June 2026) is open! Abstracts must be submitted by 16 Jan. 👉 www.physoc.org/events/uk-gl... Our next speaker is Giles Hardingham from UK DRI @ukdri.ac.uk and the University of Edinburgh @edinburgh-uni.bsky.social
January 5, 2026 at 12:07 PM
📢 Registration for our second UK Glia meeting (8–9 June 2026) is open! Abstracts must be submitted by 16 Jan. 👉 www.physoc.org/events/uk-gl... Our next speaker is Giles Hardingham from UK DRI @ukdri.ac.uk and the University of Edinburgh @edinburgh-uni.bsky.social
From astrocytes to spiking neural networks !!
From a study that upended astrocyte research to one that reignited the field of spiking neural networks, experts weighed in on the papers that significantly shaped how they think and approach neuroscience.
#neuroskyence
www.thetransmitter.org/this-paper-c...
#neuroskyence
www.thetransmitter.org/this-paper-c...
The best of ‘this paper changed my life’ in 2025
From a study that upended astrocyte research to one that reignited the field of spiking neural networks, experts weighed in on the papers that significantly shaped how they think about and approach…
www.thetransmitter.org
January 5, 2026 at 5:26 PM
From astrocytes to spiking neural networks !!
An earlier late breaking news talk on switching dynamics in working memory model showing complex MMOs proposed for efficient WM hardware implementation using SNNs in March at NICE 2025.
www.youtube.com/watch?v=zVDu...
www.youtube.com/watch?v=zVDu...
24 - Ghanendra Singh (TU Graz, Austria) - Late breaking news
YouTube video by Neuro Inspired Computational Elements Conference
www.youtube.com
December 22, 2025 at 7:50 AM
An earlier late breaking news talk on switching dynamics in working memory model showing complex MMOs proposed for efficient WM hardware implementation using SNNs in March at NICE 2025.
www.youtube.com/watch?v=zVDu...
www.youtube.com/watch?v=zVDu...
Reposted by Ghanendra Singh
Scientists at the Salk Institute have now discovered a molecule that is critical for stabilizing brain circuits in adulthood: a protein called CCN1 secreted by star-shaped cells called astrocytes.
www.salk.edu/news-release...
www.salk.edu/news-release...
December 19, 2025 at 9:38 PM
Scientists at the Salk Institute have now discovered a molecule that is critical for stabilizing brain circuits in adulthood: a protein called CCN1 secreted by star-shaped cells called astrocytes.
www.salk.edu/news-release...
www.salk.edu/news-release...
Human model of the BBB for NVD.
New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10
December 17, 2025 at 5:03 AM
Human model of the BBB for NVD.
Reposted by Ghanendra Singh
Cortical astrocytes flexibly encode reward contingencies and shape conditioned behavior https://www.biorxiv.org/content/10.64898/2025.12.08.693010v1
December 11, 2025 at 3:15 PM
Cortical astrocytes flexibly encode reward contingencies and shape conditioned behavior https://www.biorxiv.org/content/10.64898/2025.12.08.693010v1
Reposted by Ghanendra Singh
The outsized role of our brain astrocytes
nature.com/articles/d41...
nature.com/articles/d41...
December 3, 2025 at 5:34 PM
The outsized role of our brain astrocytes
nature.com/articles/d41...
nature.com/articles/d41...