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Jason Plemel

@jrplemel.bsky.social

260 followers 250 following 14 posts

Husband, Father, and Associate Prof @UAlberta_FoMD. Studying in all things glia. Hoping to #endMS. [email protected]

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Reposted by Jason Plemel

Lara K. Mahal @glycocode.bsky.social · Aug 1

🧪

Trushar Patel, PhD, DSc, FRSC @trushar7.bsky.social · Aug 1

My amazing Department of Chemistry and Biochemistry at @ulethbridge.ca is seeking a motivated & talented candidate for a tenure-track Assistant Professor position in the area of experimental chemistry.
We encourage you to apply or help spread the word!
uleth.peopleadmin.ca/postings/8541

Faculty of Arts & Science - Assistant Professor (Chemistry and Biochemistry)

The Department of Chemistry and Biochemistry at the University of Lethbridge invites applications for a tenure-track position in any area of experimental chemistry. This appointment will be at the ran...

uleth.peopleadmin.ca

Jason Plemel @jrplemel.bsky.social · Jun 26

Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner

Reposted by Jason Plemel

Development @dev-journal.bsky.social · Jun 17

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Read this Research Article from our special issue on lifelong development #LifelongDevSI, by Brady Hammond, @jrplemel.bsky.social & co.:
journals.biologists.com/dev/article/...

Figure 4 (L) Density maps depicting the spatiotemporal expression patterns of Il34 and Csf1 transcripts in RNAscope™ across development. Warmer colours indicate greater, while cooler colours indicate lower, transcript density.

Jason Plemel @jrplemel.bsky.social · Jun 17

Excited to get going for the 2025 #endMS_SummerSchool !
It takes a village! Look at all the welcome packages for those who make this event happen

Jason Plemel @jrplemel.bsky.social · Jun 13

Two in one week! An amazing MSc Defence for Rebecca John, co-supervised by Karim Fouad and myself.

Jason Plemel @jrplemel.bsky.social · Jun 12

Super proud of Brady Hammond for successfully defending his PhD today. Well done Brady!

Jason Plemel @jrplemel.bsky.social · Jun 3

Thank you @ghazeskandari.bsky.social !

Jason Plemel @jrplemel.bsky.social · Jun 3

Wonderful collaborators supported this work, Steve Lacroix, @bradleykerr.bsky.social, and @markcembrowski.bsky.social!

Funding from @nserc-resnet.bsky.social

Jason Plemel @jrplemel.bsky.social · Jun 3

Surprisingly, in transgenic mice with more developmental microglia proliferation, CSF1 and IL34 were unchanged, meaning that other factors are involved in regulating microglia proliferation.

Jason Plemel @jrplemel.bsky.social · Jun 3

To get at this, Brady tested many factors and found that only CSF1R ligands like CSF1 and IL34 promote microglia proliferation. Both CSF1 and IL34 are found in the developing brain to regulate microglia proliferation.

Jason Plemel @jrplemel.bsky.social · Jun 3

Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...

journals.biologists.com

Jason Plemel @jrplemel.bsky.social · Jun 2

Amazing work by @iammadho.bsky.social 👇
Check it out

Madelene Faye Ho @iammadho.bsky.social · Jun 2

Ecstatic to post my 1st first author review!

Ever wondered about the immune cell perspective on sex differences within the PNS under pain? Do I have news for you 📝🗯️🦠🔬🤕

Read it here: doi.org/10.1016/j.bb...

So grateful to write this under the labs of @bradleykerr.bsky.social @jrplemel.bsky.social

Reposted by Jason Plemel

Canadian Association for Neuroscience @canacn.bsky.social · May 1

Graduate student and post-doc (Neuroimmunology & High-Throughput Immunometabolic Profiling in MS) positions available in Dr. Deepak Kaushik's laboratory at Memorial University #neurojobs can-acn.org/msc-phd-posi... can-acn.org/postdoctoral...

MSc/PhD Position at the Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada – Canadian Association for Neuroscience

Dr. Deepak Kaushik, Assistant Professor at the Faculty of Medicine, Memorial University of Newfoundland (MUN, St. John’s, Canada), is currently recruiting MSc/PhD fellows to join a CIHR-funded…

Reposted by Jason Plemel

Ryan Flynn @raflynn5.bsky.social · Apr 18

Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease

@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

sciencedirect.com

Reposted by Jason Plemel

Christina Wolfson @cwolfs1.bsky.social · Apr 15

Congratulations to all accepted SS & SPRINT applicants. The application quality was outstanding but sadly we are unable to accept everyone. A truly national🍁program. Can't wait to meet you in Edmonton. @ualberta.bsky.social, @jrplemel.bsky.social, @rimuhc.bsky.social, @healthsciences.mcgill.ca

endMS Training Program @endms.bsky.social · Apr 15

Excited to share this month's #endMS newsletter unveiling the list of successful #endMS_SummerSchool and #endMS_SPRINT applicants, achievements, publications and more! View the full issue here: bit.ly/endMS_Newsle...

April 2025 endMS Bits and Pieces Newsletter

Jason Plemel @jrplemel.bsky.social · Mar 7

Check out this exciting work by @philgrossphd.bsky.social in the @jkhuang.bsky.social lab! Thanks for asking us to be a part of it

Phil Gross, PhD @philgrossphd.bsky.social · Mar 7

Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...

1/3

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications

The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...

Reposted by Jason Plemel

M. Natasha Rajah 🇨🇦 @mnrajah.bsky.social · Mar 5

Bye bye 👋🏽 🇺🇸 beer, wine, & liquor

The scene at our local LCBO

#capoli

Reposted by Jason Plemel

Timothy Caulfield @caulfieldtim.bsky.social · Mar 4

💪

Reposted by Jason Plemel

Doug Gordon @brooklynspoke.bsky.social · Mar 4

I knew this would happen, but it's still surreal to hear another nation's leader talk to us in a televised address the way US presidents have historically spoken to the citizens of countries led by dictators and despots.

Aaron Rupar @atrupar.com · Mar 4

Trudeau: "I want to speak first directly to the American people. We don't want this. We want to work with you as a friend and ally. We don't want to see you hurt either. But your government has chosen to do this to you. As of this morning, markets are down and inflation is set to rise dramatically."

Reposted by Jason Plemel

Baptiste Lacoste @blacoste.bsky.social · Mar 1

I hope you haven’t missed this awesome new study by
@caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience

The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

Jason Plemel @jrplemel.bsky.social · Feb 28

A special thanks to Rebecca John who did such a great job with this project. Also for the funding from International Spinal Research Fund and the Christopher and Dana Reeve Foundation with support CIHR and CRC

Jason Plemel @jrplemel.bsky.social · Feb 28

link.springer.com/article/10.1...

Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states - Journal of Neuroinflammation

Background Rehabilitative training is an effective method to promote recovery following spinal cord injury (SCI), with lower training efficacy observed in the chronic stage. The increased training eff...

link.springer.com

Jason Plemel @jrplemel.bsky.social · Feb 28

Check out a recent paper by Karim Fouad and my groups examining how reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states

Reposted by Jason Plemel

Andrew Octavian Sasmita @aosasmita.bsky.social · Jan 30

Oligodendrocyte precursor cells facilitate neuronal lysosome release

Oligodendrocyte precursor cells facilitate neuronal lysosome release - Nature Communications

Oligodendrocyte precursor cells (OPCs) play a multifaceted role in the brain. Here, the authors show that OPCs regulate neuronal metabolism by forming contacts with neuronal somata, facilitating lysos...

Reposted by Jason Plemel

Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · Jan 18

Wise words from another Nobel laureate.

Maximiliano José Nigro @maxnigro.bsky.social · Jan 18

Take a look at this passage from the autobiography of Van Essen from the same SfN series