Lightnews — Scholar-powered news

The Kueh lab @kuehlab.bsky.social · 4d

Congrats Nik, Julie and Brian!

Reposted by The Kueh lab

Nik Joshi @nikjoshilabyale.bsky.social · 6d

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.

This was a collaboration between Julie Cheung and Brian Hunt
in the lab

Thanks to Cancer Cell for publishing our work.

www.cell.com/cancer-cell/...

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

www.cell.com

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Reposted by The Kueh lab

Kilian Schober @kischober.bsky.social · 5d

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

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Reposted by The Kueh lab

Waggoner Lab @labwaggoner.bsky.social · 9d

@biorxivpreprint.bsky.social STAT3 operates as an inflammation-dependent transcriptional switch @josephsunlab.bsky.social @simongrassmann.bsky.social @mskcancercenter.bsky.social
www.biorxiv.org/content/10.1...

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Reposted by The Kueh lab

Golnaz Vahedi @vahedilab.bsky.social · 15d

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Research Specialist A/B

University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

wd1.myworkdaysite.com

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Reposted by The Kueh lab

Joanna Groom @groomlab.bsky.social · 27d

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...

This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social

Thread below...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

www.nature.com

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The Kueh lab @kuehlab.bsky.social · Aug 20

One more thing to mention: we are thrilled to be joining the vibrant and growing Systems Immunology community here, led by @tsanglab.bsky.social. There will be much collaborative work with the vision of understanding and rebuilding the immune system from the ground up, so stay tuned!

The Kueh lab @kuehlab.bsky.social · Aug 19

We have some news to share: The Kueh lab is moving to ‪Yale this fall!‬ We will be joining the Yale Center for Systems and Engineering Immunology ‪@yalecsei.bsky.social‬ and the Department of Immunobiology.

medicine.yale.edu/systems-engi...

Research

The immune system is a spatially distributed, whole-body sensory-reactive system that monitors, reacts, and adapts to various stress signals (e.g., tissue

medicine.yale.edu

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The Kueh lab @kuehlab.bsky.social · Aug 19

As we setup our lab here, we will be looking to recruit at all levels, from students and postdocs to research /management personnel. If you are motivated and curious to understand and engineer the immune system, send me a message.

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The Kueh lab @kuehlab.bsky.social · Aug 19

We are sad to leave to @uwbioe.bsky.social‬, UW and Seattle, and are grateful for the wonderful friends, collaborators and colleagues that have gotten to know here over the years. We will miss you all.

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The Kueh lab @kuehlab.bsky.social · Aug 19

We have some news to share: The Kueh lab is moving to ‪Yale this fall!‬ We will be joining the Yale Center for Systems and Engineering Immunology ‪@yalecsei.bsky.social‬ and the Department of Immunobiology.

medicine.yale.edu/systems-engi...

Research

The immune system is a spatially distributed, whole-body sensory-reactive system that monitors, reacts, and adapts to various stress signals (e.g., tissue

medicine.yale.edu

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Reposted by The Kueh lab

Sarah Ross @sarahhross.bsky.social · Aug 7

This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.

Science Magazine @science.org · Aug 7

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health.

Learn more: scim.ag/3IYhnk7

This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age.

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Reposted by The Kueh lab

Jeff Mold @jeffmold.bsky.social · Jul 3

Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃

Identification of proliferating neural progenitors in the adult human hippocampus

Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...

www.science.org

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Reposted by The Kueh lab

EPIGENETIC HULK @epigenetichulk.bsky.social · Jun 13

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

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The Kueh lab @kuehlab.bsky.social · Jun 7

For a summary, check out: x.com/Kueh_Lab/sta... (apologies, but this is on the old platform)

KuehLab on X: "Our latest preprint, on T cell receptor (TCR) signaling by condensate nucleation! This theory + experiment study was led by the brilliant Will White, with Jay Groves @UCB_Chemistry and David Baker @UWproteindesign and @Arielbs100. (1/n) https://t.co/JGLukouM44" / X

Our latest preprint, on T cell receptor (TCR) signaling by condensate nucleation! This theory + experiment study was led by the brilliant Will White, with Jay Groves @UCB_Chemistry and David Baker @UWproteindesign and @Arielbs100. (1/n) https://t.co/JGLukouM44

x.com

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The Kueh lab @kuehlab.bsky.social · Jun 7

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social

www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Reposted by The Kueh lab

Eric Topol @erictopol.bsky.social · May 31

First Phase 2 randomized trial of engineered T cells for a solid tumor—GI cancer— with some encouraging results
www.thelancet.com/journals/lan... @thelancet.com

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Reposted by The Kueh lab

Golnaz Vahedi @vahedilab.bsky.social · Jun 2

🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

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The Kueh lab @kuehlab.bsky.social · May 20

Congratulations Joe and Endi!

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Reposted by The Kueh lab

Joseph Sun Lab @josephsunlab.bsky.social · May 20

Check out this new study and TCR Tg mouse generated by Endi Santosa @endicytosis.bsky.social. If you are interested in studying classic and inflationary CD8+ T cell memory to MCMV infection, we’re happy to share this mouse, and @laboxenius.bsky.social is extremely generous with her Tg lines as well.

Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection | Journal of Experimental Medicine | Rockefeller University Press

Our findings reveal a divergent transcriptomic and epigenetic landscape between conventional and inflationary memory responses in spleen and liver during l

rupress.org

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Reposted by The Kueh lab

Anders Sejr Hansen @andersshansen.bsky.social · May 7

(1/n) New preprint from @claricehongky.bsky.social
Fan Fang Varshini Ramanathan in collab w Jie Liu.

Q: How do we get ultra-high-res 3D genome maps?

A: New deep learning model, Cleopatra.

Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.

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The Kueh lab @kuehlab.bsky.social · May 4

Congratulations @anshulkundaje.bsky.social and co-workers! I'm partial to the composite TF motifs in thymic/immune development but this is a fantastic resource for many fields!

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Reposted by The Kueh lab

Anshul Kundaje @anshulkundaje.bsky.social · May 4

Check out this great resource of single cell multiome data, cell annotations, regulatory DNA models of cell type resolved chromatin accessibility & comprehensive annotation of motifs & sequence syntax for multiple tissues in early human development 1/

Selin Jessa @selinjessa.bsky.social · May 3

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️

Dissecting regulatory syntax in human development with scalable multiomics and deep learning

Transcription factors (TFs) establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility, and regulating gene expre...

www.biorxiv.org

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Reposted by The Kueh lab

Carl T. Bergstrom @carlbergstrom.com · Mar 19

1. For the past thirty years I've had the best job in the world.

 I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.

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Reposted by The Kueh lab

Vijay G. Sankaran @bloodgenes.bsky.social · Apr 3

Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

www.science.org

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Reposted by The Kueh lab

Jeremy Berg @jeremymberg.bsky.social · Mar 28

Powerful new Washington Post story up...

wapo.st/426d9fT

(Gift link)

1/n

Trump promised scientific breakthroughs. Researchers say he’s breaking science.

NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.

wapo.st

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