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Lüders Lab @luderslab.bsky.social · Aug 30

Salt marshes ‘ Las Salinas’, Cabo de Gata Natural Park, Spain

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Reposted by Lüders Lab

Marco MILAN LAB @milanlab.bsky.social · Aug 16

Why would anyone want to be a scientist? url: journals.biologists.com/jcs/article/...

Why would anyone want to be a scientist?

It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...

journals.biologists.com

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Reposted by Lüders Lab

Simone Reber @simonereber.bsky.social · Aug 15

FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz

💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes

Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...

rdcu.be

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Reposted by Lüders Lab

MwahahahahahadScientist @mads100tist.bsky.social · Jul 13

See? There's money! What would be great, instead, is to increase the budget for the existing schemes, though 🧪

ERC to introduce seven-year €7 million ‘super grants’ in 2026

The European Research Council (ERC) is set to launch its first seven-year €7 million super grant call in May next year.The grants, called ERC+, will be open to researchers at all career stages and in ...

sciencebusiness.net

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Reposted by Lüders Lab

Graham Dellaire @docdellaire.bsky.social · Jul 13

"Super level" funding programs IMO are a huge waste of money - they benefit big labs at the cost of defunding others. We had big "Foundation grants" in Canada (albeit at a much smaller scale than similar programs in the USA/EU)... TL;DR it nearly ruined the sustainability of our research ecosystem

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Lüders Lab @luderslab.bsky.social · Jul 9

…as wobbly tentacles that capture you?

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Reposted by Lüders Lab

Toni Gabaldón @tonigabaldon.bsky.social · Jul 9

The #ESEB2025 meeting in Barcelona is getting closer, there are still places available but time for registration is running up. Are you going to miss the main evolutionary biology event in Europe this year?
👇
eseb2025.com/registration/

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Reposted by Lüders Lab

Elias Spiliotis @septinlab.bsky.social · Jul 6

Woah! Sick reconstitution work showing that MAP6d1 recruits tubulin to form B tubules on A tubule templates, and ALSO intra-luminal protofilaments, which apparently are present in neuronal microtubules.
So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!

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Lüders Lab @luderslab.bsky.social · Jul 3

Check out this new 🔥work from Bryan Tsou’s lab - where does the information on how to assemble #centrioles with specific symmetry come from? Forget what you thought you knew about #centriole #biogenesis!!!

www.biorxiv.org/content/10.1...

Centriole biogenesis is seeded by CEP152-CEP63-PCNT aggregates propagating outside the centriole through the Alström syndrome protein ALMS1

While subcellular structures like centrioles assemble flawlessly from protein components, it is unknown whether instructions from outside the components are involved. Centrioles build on the cartwheel...

www.biorxiv.org

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Lüders Lab @luderslab.bsky.social · Jul 2

It is alive!!!
Prompt to Google’s Vids AI video generation tool: “Show #microtubule #nucleation from gamma-tubulin ring complexes with microtubules displaying dynamic instability.”

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Lüders Lab @luderslab.bsky.social · Jul 2

A new AI video generation tool popped up in my Google workspace today - this did not go so well 😂
I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”

Lüders Lab @luderslab.bsky.social · Jul 1

Great news and congrats Monica, happy to have you in Barcelona!

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Lüders Lab @luderslab.bsky.social · Jul 1

Great news not only for the #CRG but also for the wider Barcelona cell biology research community! And of course also for all #centrosome and #cilia aficionados!

Monica Bettencourt-Dias @monicabettencourt.bsky.social · Jul 1

Excited about this new role! I have admired CRG for long, its amazing science, and how it constantly innovates in how research is done and how it connects with society. Happy to follow Luis Serrano´s work with this incredible community + the ecosystem it is part of & push the boundaries together!

Centre de Regulació Genòmica (CRG) @crg.eu · Jul 1

Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...

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Lüders Lab @luderslab.bsky.social · Jun 16

Planning killer experiments during evening ride with view

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Lüders Lab @luderslab.bsky.social · Jun 5

#UExM Tetris by @luderslab.bsky.social members Marcos Fariña and Júlia Mestres reveals highly abnormal #centriole configurations 👀

IRB Barcelona @irbbarcelona.org · Jun 5

Let's start this Thursday having some fun with #June 's Image of the Month!

🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.

Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!

#ImageOfTheMonth #CancerResearch

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Lüders Lab @luderslab.bsky.social · May 24

During #mitosis, before assembling the mitotic spindle, the early mouse embryo lacking #centrosomes uses #actin rather than #microtubules for chromosome congression 👀👇🏼

Blake Hernandez @loxstoplox.bsky.social · May 23

I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)

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Lüders Lab @luderslab.bsky.social · Mar 26

Congratulations Pleasantine!
🏅

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Reposted by Lüders Lab

Lars Velten @larsplus.bsky.social · Feb 26

This is big - the effect of cancer mutations on HSCs is determined by pre-existing properties of the stem cell affected! Crazy results on NPM1 🤩

Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · Feb 25

🔥 New Fraticelli lab publication🔥

“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”

Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.

Performed with the support of Cris Cancer and @erc.europa.eu

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Lüders Lab @luderslab.bsky.social · Feb 26

Congrats Alejo and team!

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Lüders Lab @luderslab.bsky.social · Feb 10

Insightful work from the Raff lab on how to build mitotic centrosomes (including artificial ones)!

Raff Lab @jrafflab.bsky.social · Feb 10

🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...

Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes

Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.

www.science.org

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Reposted by Lüders Lab

Moe Mahjoub @mahjoublab.bsky.social · Jan 29

🚨New paper out!🚨

Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan
@dutcherlab.bsky.social and Steve Brody.

We asked a simple question: why do some PCD patients develop more severe lung disease than others?
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www.science.org/doi/10.1126/...

Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia

CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.

www.science.org

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Reposted by Lüders Lab

Lotte B. Pedersen @lottepedersen.bsky.social · Jan 27

We are now accepting applications for two PhD positions within the Cilia-AI PhD training network (cilia-ai.eu). Please apply via the link below. Application deadline March 15th, start date September 1st, 2025.

employment.ku.dk/all-vacancies/…

https://employment.ku.dk/all-vacancies/…

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Lüders Lab @luderslab.bsky.social · Jan 24

Hmm… customs GIFs are not working yet it seems?
So here is what we do in a movie!

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Reposted by Lüders Lab

David Mick @mick-lab.bsky.social · Jan 11

Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.

Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade

Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...

www.biorxiv.org

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Lüders Lab @luderslab.bsky.social · Jan 10

Important to note that the letter should be literally a great letter, not just claim that the student is outstanding, as many generic letters also do, but those letters don’t get the student very far.

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