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Elias Spiliotis @septinlab.bsky.social · 1d

Ooo-la-la!

EMBO @embo.org · 1d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Reposted by Elias Spiliotis

Victor Tatarskiy @greenrat.bsky.social · 6d

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky

On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.

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Elias Spiliotis @septinlab.bsky.social · 7d

Exciting news!

Submissions are now open for the first @ascbiology.bsky.social #MBOC Spercial Issue on #Septins

Submission deadline: April 30, 2026

RT and spread the word at #CellBio2025

www.molbiolcell.org/cell-biology...

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Elias Spiliotis @septinlab.bsky.social · 7d

I was thinking about making reservations at a couple of my favorite places today! No joke.

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Elias Spiliotis @septinlab.bsky.social · 7d

NYTimes biopic and chronicle on Stephen Starr who can be credited for the start of Philly's culinary scene.
Good source of restaurant names for your Philly ASCB lab dinners.
www.nytimes.com/2025/09/30/d...

The $400 Million Restaurant Man

www.nytimes.com

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Reposted by Elias Spiliotis

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 9d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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Elias Spiliotis @septinlab.bsky.social · 9d

Congrats!

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Elias Spiliotis @septinlab.bsky.social · 9d

👏

Jeremy Berg @jeremymberg.bsky.social · 9d

The fiscal year ends tomorrow.

Here are results from NIH Reporter downloaded an hour ago.

The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.

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$A graph showing the fraction of annual grant funding committed for NIH for fiscal years 2015 to 2025. The fiscal year 2025 lagged behind but then caught up over the last two months.$

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Elias Spiliotis @septinlab.bsky.social · 9d

Kudos to NYTImes for running this!
Misfit rock'n'roll drummers for 500...
www.nytimes.com/2025/09/28/a...

Viv Prince, Rock’s Original Madman Drummer, Is Dead at 84

www.nytimes.com

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Reposted by Elias Spiliotis

David Brückner @davidbrueckner.bsky.social · 12d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

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Elias Spiliotis @septinlab.bsky.social · 14d

#SeptforSeptins

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Reposted by Elias Spiliotis

Mark Peifer (He, him) @peiferlabunc.bsky.social · 15d

Write your program officer and grants management official TODAY and thank them! It takes 30 seconds and its really appreciated. The only reason they're remotely this close is because those folks are working 60 hour weeks under immense pressure

Jeremy Berg @jeremymberg.bsky.social · 15d

Here are data on the percentage of FY2024 appropriation committed to date in FY2025. Most ICs are well on track, but four ICs (NIMHD, NINR, NHLBI, NHGRI) still appear to be under 80%.

Note that values >100% reflect either a higher appropriation for FY25 or an increased % devoted to grants.

A table of the percentage of fiscal year 2025 funding compared to fiscal year 2024 for 25 NIH institutes and centers (and the Office of the Director).

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Elias Spiliotis @septinlab.bsky.social · 14d

#SeptforSeptins

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Elias Spiliotis @septinlab.bsky.social · 15d

I think I have spent all my R35's annual budget on Sigma's GOLDEN 25% off sale...

a man is sitting on a boat taking a picture of the water with an ethereum logo in the background .

ALT: a man is sitting on a boat taking a picture of the water with an ethereum logo in the background .

media.tenor.com

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Reposted by Elias Spiliotis

Robert Grosse @ grosselab @grosselab.bsky.social · 16d

we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social

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Reposted by Elias Spiliotis

epithelial mechanics fan club @epimechfc.bsky.social · 17d

Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.

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Elias Spiliotis @septinlab.bsky.social · 17d

Put it in the Louvre!

Nick Piccone @piccone.bsky.social · 17d

8. EAGLES BLOCK THE FIELD GOAL [AGAIN] TO WIN THE GAME!

JORDAN DAVIS!

Elias Spiliotis @septinlab.bsky.social · 19d

This is so great! Beautiful song in the newest Ty Segall LP
60s psych melodies and great guitar solo leads
www.youtube.com/watch?v=UbDq...

Ty Segall "Possession" (Official Song Video)

YouTube video by Drag City

www.youtube.com

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Reposted by Elias Spiliotis

Graham Dellaire @docdellaire.bsky.social · 19d

Got inspired mid-week by Ty Segall’s Tiny Desk Concert and picked up the guitar… then tried to figure out some of the drumming. Got to 7 min into the video - Turn this 💩 up loud and enjoy - better than any alarm clock to get the blood pumping youtu.be/nZzJwMXMvwE?...

Ty Segall: Tiny Desk Concert

YouTube video by NPR Music

youtu.be

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Reposted by Elias Spiliotis

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 20d

that was NOT FUNNY

Mike Masnick @mmasnick.bsky.social · 20d

The @thedailyshow.com has its entry into "how do we respond to the Kimmel situation." www.youtube.com/watch?v=_GXN...

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Reposted by Elias Spiliotis

Daniel Alber @danielalber.bsky.social · 20d

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!

Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

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Reposted by Elias Spiliotis

myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 19d

Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

- nice work showing that an F-actin cage-like structure surrounding oocytes polar MTOCs relies on MYO10 and MYO7B.

www.nature.com/articles/s41...

Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation - Nature Communications

Errors in oocyte division can cause infertility and birth defects. Here, authors combine a genetic strategy with a novel optochemical tool to show that spindle pole-localized F-actin is essential for ...

www.nature.com

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Elias Spiliotis @septinlab.bsky.social · 19d

Hak-tuah, exciting news!

Spirochrome @spirochrome.com · 19d

HAK-actin™: a new probe to label #actin in your expansion microscopy samples with a robust yet simple protocol.

Find out how HAK-actin™ can help you achieve a bright actin staining in your ExM workflow: spirochrome.com/product/hak-...

Image credits: Olivier Mercey, UNIGE

U-ExM expanded HeLa cell stained with HAK-actin (orange) and DNA (blue).

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Reposted by Elias Spiliotis

epithelial mechanics fan club @epimechfc.bsky.social · 23d

Mäntylä, E., & Ihalainen, T. O. (2021). Brick Strex: a robust device built of LEGO bricks for mechanical manipulation of cells. Scientific Reports, #EpithelialMechanics www.nature.com/articles/s41...

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Elias Spiliotis @septinlab.bsky.social · 23d

SPY dyes go up by ~24% on Monday.

Get them now from Cytoskeleton if your stocks getting low.