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Reposted by Maja Radulovic

Ishier Raote @ishier.bsky.social · 9d

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology

Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

www.nature.com

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Reposted by Maja Radulovic

Luis Bonet-Ponce @lysoluis.bsky.social · 14d

Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!

Journal of Cell Biology @jcb.org · 14d

@lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...

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Reposted by Maja Radulovic

Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 25

Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof

CHIP protects lysosomes from CLN4 mutant-induced membrane damage

Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...

rdcu.be

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Reposted by Maja Radulovic

Cell Biology J-Club @cellclub.bsky.social · Aug 21

LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...

LYVAC/PDZD8 is a lysosomal vacuolator

Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

www.science.org

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Reposted by Maja Radulovic

Nature @nature.com · Aug 21

Nature research paper: Quantitative imaging of lipid transport in mammalian cells

go.nature.com/4mmSygd

Quantitative imaging of lipid transport in mammalian cells - Nature

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

go.nature.com

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Maja Radulovic @majarad.bsky.social · Aug 6

Thank you so much! It goes both ways :-)

Maja Radulovic @majarad.bsky.social · Aug 5

Interested in lysosome damage and repair pathways? Check out the latest updates.

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · Aug 4

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease

Lysosomal membrane homeostasis and its importance in physiology and disease

Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

bit.ly

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Reposted by Maja Radulovic

Felix Campelo @felixmendu.bsky.social · Jul 4

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio

meetings.embo.org/event/26-org...

Intracellular mechanics and organelle mechanobiology

Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

meetings.embo.org

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Reposted by Maja Radulovic

Juan Martin Serrano @juanmartin-serrano.bsky.social · Jun 27

What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event

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Reposted by Maja Radulovic

Jim Hurley @jimhurley.bsky.social · Jun 25

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

The expanding repertoire of ESCRT functions in cell biology and disease - Nature

This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

tinyurl.com

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Reposted by Maja Radulovic

Roux Lab, Geneva @rouxlab.bsky.social · Mar 28

A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt

ESCRT function, evolutionary diversity and mechanism of action

The ESCRTs (Endosomal Sorting Complexes Required for Transport) were discovered in 2002 and became one of the most dynamic fields of research in membrane cell biology. ESCRTs are protein complexes fo…

meetings.embo.org

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Maja Radulovic @majarad.bsky.social · Mar 27

Amazing! Can't wait to read it in detail. Congratulations!

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