For the first time, researchers have observed live and in high resolution how influenza viruses infect living cells. This was possible thanks to a new microscopy technique, which could now help to dev...

Mitophagy selectively removes depolarised and damaged mitochondria, promoting cell viability. Some members of the Orthoflavivirus genus activate mitophagy to allow extended replication times in a surv...

Rather than adapting to the codon usage of their host, viruses use viral 5′ untranslated regions to initiate translation, which allows them to produce viral proteins in host cells efficiently despite ...

Abstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st

The reliability of single-cell proteomics (SCP) is intrinsically linked to the fidelity of cell isolation; however, the identification of co-isolated cells (doublets or multiplets) remains a persisten...

PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York, listed on FindAPhD.com

The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

Laridae birds, such as gulls, are known reservoirs of H13 and H16 low pathogenic avian influenza subtypes. However, during the recent outbreaks linked to the reemergence of high pathogenicity avian in...

During the long-term symbiosis with the host, IAVs have evolved a series of unique mechanisms to adapt to the host and support their own replication. The MAVS-mediated IFN-I signaling pathway is crucial for host cells to defend against RNA virus invasion, with TRIM31 functioning as a specific agonist for the activation of IFN-I antiviral response. In the present study, we demonstrated that IAV exploits TRIM31 to promote the stability and activity of viral proteins and reduces the positive effect of TRIM31 on the IFN-I response, thereby preventing TRIM31 from inhibiting IAV replication. Therefore, our results revealed a novel mechanism employed by IAV to adapt to host antiviral response and expanded our understanding of virus–host interactions.

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

Apply for a PhD: The MRC-University of Glasgow Centre for Virus Research (CVR) PhD Funded Programme at University of Glasgow

Accurately quantifying viral genetic diversity is essential for understanding pathogen evolution, transmission, and emergence. However, standard approaches that map sequencing reads to a single linear...

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

18 fully funded studentships for October 2026 start: interdisciplinary infection bioscience training to address disease threats to human and animal health.