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Matti Pronker

@mfpronker.bsky.social

310 followers 380 following 61 posts

Junior Director sdAb engineering at QVQ, structural biology, protein engineering, #cryoEM ❄️🔬, #crystallography 💎 - views are my own

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Matti Pronker @mfpronker.bsky.social · Jun 22

The final reviewed version of our FLAG/anti-FLAG M2 structure paper is now out fully open access in the Journal of Molecular Biology: www.sciencedirect.com/science/arti...
Many thanks to Wouter Beugelink, Els Sweep, Bert Janssen and @joostsnijder.bsky.social

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Reposted by Matti Pronker

eileen chengyin chow @chowleen.bsky.social · 11d

The South Korean Ministry of Defense has awarded medals of merit to 11 officers for disobeying direct orders of superiors during the martial law fiasco, orders that they deemed to be contrary to the constitution and endangerment to democracy.
www.chosun.com/english/nati...

National Defense Ministry Honors 11 Soldiers for Refusing Illegal Orders

National Defense Ministry Honors 11 Soldiers for Refusing Illegal Orders Honored for rejecting illegal orders during martial law, Marine death probe

www.chosun.com

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Matti Pronker @mfpronker.bsky.social · 20d

Disney cancels @jimmykimmel.com , I cancel Disney Plus, byebye!

Reposted by Matti Pronker

Denise Walker @denisewalker.bsky.social · 21d

This year, for Postdoc Appreciation Week, could we please STOP referring to them as TRAINEES!

They are exceptionally qualified professionals, highly experienced researchers, mentors, educators, world-leading experts in their field, grownups with responsibilities, not interns!

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Matti Pronker @mfpronker.bsky.social · 25d

Has anybody solved this conundrum?

Matti Pronker @mfpronker.bsky.social · 25d

As it's the season, 3 options for those wishing to cook pumpkin:
1. Suffer when trying to peel a raw pumpkin
2. Boil the pumpkin with skin on (skin comes of easily), suffer when trying to clean the pot later
3. Suffer when eating the awful pre-cut pumpkin (fridge or frozen) 🥴

Matti Pronker @mfpronker.bsky.social · 26d

Isopeptide bond?

Matti Pronker @mfpronker.bsky.social · 26d

You mean the most valuable company in the world?

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Matti Pronker @mfpronker.bsky.social · 26d

It seems trendy lately to have visualizations of 3D proteins structures generated by AI. These show very ugly artifacts, akin to AI pictures of humans with the wrong number of fingers. It is really not hard to make a visualization of a random protein structure using free software! #AI-slop

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Reposted by Matti Pronker

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Sep 1

We are experiencing a period of remarkable technological advancement ( #CryoEM, #CRISPR, #alphafold, protein design) unparalleled in the past decade.

Keeping pace is challenging, continuously adapting to technological developments that may become obsolete by the time you've mastered them. 🤕

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Matti Pronker @mfpronker.bsky.social · Aug 13

But what does it do?? 😉

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Reposted by Matti Pronker

Joost Snijder @joostsnijder.bsky.social · Jul 22

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social

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Reposted by Matti Pronker

Science Magazine @science.org · Jul 22

In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. #WorldBrainDay scim.ag/3FvpAKy

A single neuron (white) shown with 5,600 of the axons (blue) that connect to it. The synapses that make these connections are shown in green. The cell body (central core) of the neuron is about 14 micrometers across.

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Reposted by Matti Pronker

Suzanne C. Jansen @suzannejansen.bsky.social · Jul 17

Preprint alert! With #PFAS contamination becoming an environmental crisis, we dared to engineer natural defluorinases towards degradation of (un)natural organofluorides. How? Check out our robust growth-based selection platform here: www.biorxiv.org/content/10.1... thanks to @mayerlab.bsky.social !

Engineering fluoroacetate dehalogenase by growth-based selections to degrade non-natural organofluorides

The widespread use of organofluorides in modern society has inadvertently led to the bioaccumulation of harmful pollutants, most prominently per- and polyfluorinated alkyl substances (PFAS). In princi...

www.biorxiv.org

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Reposted by Matti Pronker

KNAW - Koninklijke Nederlandse Akademie van Wetenschappen @knaw-nl.bsky.social · Jul 10

Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...

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Matti Pronker @mfpronker.bsky.social · Jun 25

Wow, just wow!
www.nature.com/articles/s41...
I was working on that at the MRC-LMB from 2017-2019...

Gating and noelin clustering of native Ca2+-permeable AMPA receptors - Nature

Nature - Gating and noelin clustering of native Ca2+-permeable AMPA receptors

www.nature.com

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Matti Pronker @mfpronker.bsky.social · Jun 23

Cool visualization of MAG cis dimerisation and trans ganglioside binding at the axon-myelin interface by Krzyszlof Anklewicz, a bachelor student @utrechtuniversity.bsky.social. This structure was the main discovery of my PhD! Find the open access paper here: www.nature.com/articles/nco... #glycotime

Reposted by Matti Pronker

Daniel Hurdiss @danielhurdiss.bsky.social · Jun 18

Latest preprint from the lab, many years in the making!

By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.

This could have big implications for our understanding of viral replication & assembly (🧵)

www.biorxiv.org/content/10.1...

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Reposted by Matti Pronker

Chad Loder @chadloder.bsky.social · Jun 9

Four LAPD officers on horseback surround a man laying on the ground, trample him, and beat him with their polycarbonate "saber" batons.

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Reposted by Matti Pronker

Costa Samaras @costasamaras.com · May 30

This is his only biography now

ryan cooper @ryanlcooper.com · May 30

"Roughly 1,500 babies have been born HIV-positive every day since January 21, because Musk cut off their mothers’ medication." prospect.org/power/2025-0...

Go, Elon, and Never Darken Our Doors Again

The worst ultra-billionaire on Earth says he’s leaving government. Let’s hope he actually does it.

prospect.org

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Reposted by Matti Pronker

John Rubinstein @johnrubinstein.bsky.social · May 31

🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...

2026 Canada Excellence Research Chair Opportunities | Research & Innovation

research.utoronto.ca

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Matti Pronker @mfpronker.bsky.social · May 23

Next week will be the FEBS Advanced Lecture Course 'Emerging insights from structural biology into molecular mechanisms of diseases', where I will present new structural biology and protein engineering results at the 'Academia meets industry' session. Hope to see you there!

Reposted by Matti Pronker

cryoEM papers @cryoempapers.bsky.social · May 11

Liposome Encapsulation Enables Near-Native Cryo-EM Structural Determination by Shielding Macromolecules from Non-Physiological Interfaces www.biorxiv.org/content/10.1101/2025.05.06.652550v1 #cryoem

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Matti Pronker @mfpronker.bsky.social · May 9

polyglycine can actually form a cool and unique secondary structure (helices that stack together) 🤓

Matti Pronker @mfpronker.bsky.social · May 7

Nice work on coronavirus HKU1-A spike opening by Min Jin et al.:

www.nature.com/articles/s41...

With a longer glycan and higher resolution structures, they nicely confirm our conclusions (www.nature.com/articles/s41...) and add new insights.

Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes - Nature Communications

Sialoglycan receptor binding promotes the D2 domain up conformation in the HKU1 coronavirus spike protein. Here the authors show that this conformational change is driven fundamentally by the full str...

www.nature.com

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Reposted by Matti Pronker

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Apr 16

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs

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