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Mitosis Lab

@mitosislab.bsky.social

1.4K followers 670 following 21 posts

Structural cell biology @ University of Virginia Molecular Physiology and Biological Physics Former @ Dept. of Biological Sciences & CBIS, NUS anaphase.org med.virginia.edu/faculty/faculty-listing/wwh6xu mstdn.science/@MitosisLab

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Mitosis Lab @mitosislab.bsky.social · Mar 17

Happy that Jon Chen @jonchenjk.bsky.social's cryo-ET and confocal study of RPE-1 chromatin in situ is online www.embopress.org/doi/full/10.1038/s44318-025-00407-2
Congrats also to coauthors Tingsheng Liu, @shujuncai.bsky.social, Cai Tong Ng, Jian Shi and collaborators Weimei Ruan Uttam Surana.

Cryo-ET visualization of chromatin at the nucleosome level in RPE-1 cells arrested in G1 phase and metaphase.

Cryotomograms of a metaphase RPE-1 cell.

3-D class averages of mononucleosomes and ordered stacked dinucleosomes in G1 and metaphase.

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Zach Weinersmith @zachweinersmith.bsky.social · 15d

Wow www.bbc.com/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.com

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Kathleen Bachynski @bachynski.bsky.social · 15d

This is huge: “A drug that provides near-perfect protection against H.I.V. with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope… making lenacapavir a realistic choice in countries with constrained resources.”

Philanthropies Strike a Promising Deal to Turn Back H.I.V.

www.nytimes.com

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Oli Clarke @olibclarke.bsky.social · 20d

For something different, tried this approach on something on the other end of the spectrum - in situ ribosomes from low SNR 2DTM data.

Used the U2OS-grid 9 dataset from EMPIAR-12459 (699 movies; doi.org/10.1016/j.mo...).

Blob pick & 2D after denoising gave 12k particles. 2-class HR-HAIR --> 3.3 Å

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cryoEM papers @cryoempapers.bsky.social · 20d

Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoem

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Tanmay Bharat @tbharat-lab.bsky.social · Aug 31

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

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American Society for Cell Biology @ascbiology.bsky.social · Aug 18

🏅 Congratulations to Sandra Schmid (@czbiohub) on receiving ASCB’s 2025 E.B. Wilson Medal! This award honors distinguished researchers for far-reaching contributions to cell biology over a lifetime in science—an achievement Sandra exemplifies. #ASCB #CellBiology

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Basil Greber @bjgreber.bsky.social · Aug 15

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone!
www.nature.com/articles/s41...

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants - Nature Communications

Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recog...

www.nature.com

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Jenny Sachweh @jennysachweh.bsky.social · Aug 18

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!

Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!

Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

The small GTPase Ran defines nuclear pore complex asymmetry

Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…

www.sciencedirect.com

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Lennart Hilbert @lennarthilbert.bsky.social · Aug 14

Our first expansion microscopy results. Imaged today on "normal" Zeiss LSM 900, revealing chromatin and RNA polymerase II clusters at an unreal level of detail.

Our PhD student @mofrawe.bsky.social learned the protocol from amazing @mpownall.bsky.social 🙏

Months of preparation are paying off now!

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Mitosis Lab @mitosislab.bsky.social · Aug 14

Was tempted, but I'd rather not distract from the more-serious discussions posted this week 😂

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Mitosis Lab @mitosislab.bsky.social · Aug 14

Looks like us structural cell biologists will have to be satisfied with false-atomic resolution for awhile.

A paper reports a new resolution regime: "true-atomic" resolution.

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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Aug 12

Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota

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Ahmad Jomaa @jomaalab.bsky.social · Aug 1

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

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Basil Greber @bjgreber.bsky.social · Jul 30

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out:
www.sciencedirect.com/science/arti...

Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV

Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…

www.sciencedirect.com

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Iain Cheeseman @iaincheeseman.bsky.social · Jul 23

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?

www.biorxiv.org/content/10.1...

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells

In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...

www.biorxiv.org

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Michael Grange @michaelgrange.bsky.social · Jul 21

And here it is now in print! www.cell.com/cell-reports...

With a front cover splash 😍

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Anders Sejr Hansen @andersshansen.bsky.social · Jul 20

This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...

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Stan Yatskevich @stanislauy.bsky.social · Jul 15

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!

www.biorxiv.org/content/10.1...

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eLife @elife.bsky.social · Jul 12

Frustrated with confusing or conflicting requests for revisions?

At eLife, editors and reviewers discuss their reviews with each other before reaching a decision on a manuscript. Learn more about peer review at eLife: buff.ly/ioUIZyz

A visual diagram illustrating the steps in eLife's publishing process: 1. Submission, 2. Peer review, 3. Publication, 4. Author revision, and 5. Final version of record.

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Kelly Nguyen @kellythd-nguyen.bsky.social · Jul 10

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization

Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

www.science.org

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Juha Huiskonen @juhahuiskonen.bsky.social · Jul 8

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

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Mitosis Lab @mitosislab.bsky.social · Jul 2

Awesome! Congrats!

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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Jul 2

Excited and honored to be joining the EMBO Member community 🥳 Congratulations also to all the other newly elected members! -Martin

EMBO @embo.org · Jul 1

Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪

Learn more here:
www.embo.org/press-releas... #EMBOMembers2025

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO

Sixty-nine new members join the community of leading life scientists in Europe and beyond

www.embo.org

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Dimitry Tegunov @dtegunov.bsky.social · Jul 1

Whoever gets the resolution of raw tomograms to <10 Å within the sampled parts of Fourier space would probably deserve a Nobel. Or they'd get one anyway for the crazy new physics they discovered to achieve that.

Bogdan Toader @btoader.com · Jul 1

“Achieving individual tomograms of cells where any features are at 10 Å resolution or better is well-beyond both current capabilities and reasonable predictions of future improvements.”
:(

Josh Dickerson @joshdcryoem.bsky.social · Jun 28

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jun 30

Much appreciated support from biotech execs and investors 🙏

www.statnews.com/2025/06/27/b...

Proposed cuts could have ‘catastrophic effect,’ 110 biomedical, health sciences industry leaders tell Congress

Proposed cuts will have “a catastrophic effect on the advancement of biomedical and biotechnology capabilities in the United States,” more than 100 leaders of biomedical/health sciences companies tell...

www.statnews.com

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