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NiceLab

@nicelab.bsky.social

220 followers 270 following 11 posts

We study antiviral immune responses of the intestinal epithelium, especially interferon lambda. We focus on how they are specialized for the gut, interactions with normal microbiota at homeostasis, and how they may go awry during inflammatory diseases.

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NiceLab @nicelab.bsky.social · Feb 4

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...

Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda

Enteric viral infections are a major public health problem in newborns. Ramirez Reyes et al. find that the immature intestinal epithelium of newborn mice is developmentally programmed for the homeosta...

www.cell.com

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OHSU-MMI @ohsummi.bsky.social · 23d

Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.

A group foto of the MMI department at the 2025 retreat

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NiceLab @nicelab.bsky.social · Aug 30

We propose that TGFb and other barrier cytokines enable production of IFNL that acts on epithelium thereby shaping the IFN type profile of recruited pDC for maximum benefit.

NiceLab @nicelab.bsky.social · Aug 30

We found that upon recruitment to the gut pDC ‘open’ their IFNL gene locus and express other marks of TGFbeta response. Remarkably, treatment of a pDC cell line with TGFb amplifies its otherwise meager IFNL production

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NiceLab @nicelab.bsky.social · Aug 30

We were surprised to find an abundance of pDC associated with the gut epithelium and even more surprised that some of them were stimulated by microbiota to produce IFNL but not type I IFN

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Waggoner Lab @labwaggoner.bsky.social · Aug 30

@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses
www.biorxiv.org/content/10.1...

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NiceLab @nicelab.bsky.social · Aug 30

Excited to share the most recent work from our lab! In which we seek out the cellular source of homeostatic IFNL in the gut and find that gut pDC are ‘rewired’ to produce IFNL over type I IFNs.

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 29

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responses https://www.biorxiv.org/content/10.1101/2025.08.25.672167v1

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Jonathan Pruneda @jnpruneda.bsky.social · Aug 26

Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW!

facultycareers-ohsu.icims.com/jobs/35624/c...

Faculty Portal | OHSU

facultycareers-ohsu.icims.com

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International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Jun 25

Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.

International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Jun 10

Don't forget 📆 Abstract deadline for poster or oral presentations is June 18. Please repost to your network to spread the word! More info or register at seattle.cytokinesociety.org

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Christin Herrmann @christinviral.bsky.social · Jun 25

Excited to share with you my postdoctoral work published today in Nature Microbiology!

www.nature.com/articles/s41...

We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology

Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

www.nature.com

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Ram Savan @ramlabuw.bsky.social · Jun 25

Cytokines 2025: Submit your abstract for an oral or poster presentation by June 30th! Student and post-doctoral travel grants are still available. Don’t miss out!
seattle.cytokinesociety.org
#Cytokines #Immunology #innate #adaptive #conferences #Seattle

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Julie Pfeiffer @jkpfeiff.bsky.social · Jun 25

Valerie Rodriguez Irizarry’s tour de force paper on murine norovirus adaptation/egress is now out in peer-reviewed form ‪@plosbiology.org‬. It highlights the power of forward genetics in virology research. 🧵 1/10 journals.plos.org/plosbiology/...

Drawing of a cell showing mitochondria in the cytoplasm, with murine norovirus virions exiting the cell through damage to the plasma membrane. Image credit: Valerie Rodriguez Irizarry

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OHSU-MMI @ohsummi.bsky.social · May 23

This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!

Kristin Michel @kmichel.bsky.social · May 22

Excellent new study from the Catteruccia lab, co-led by Alexandra Probst and Douglas Paton www.nature.com/articles/s41...

In vivo screen of Plasmodium targets for mosquito-based malaria control - Nature

An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in th...

www.nature.com

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Cadwell Lab @cadwelllab.bsky.social · May 17

Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n

kwnsfk27.r.eu-west-1.awstrack.me

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PLOS Biology @plosbiology.org · Apr 24

Norovirus tropism depends partly on entry receptors, but what is the role of cellular #lipids? @orchardlab.bsky.social &co show that TMEM30a-mediated lipid asymmetry is crucial for murine #norovirus infection, influencing membrane fluidity, viral binding & entry @plosbiology.org 🧪 plos.io/4409MtI

Left: Based on electron microscopic (EM) imagery, this three-dimensional (3D) illustration provides a graphical representation of a ingle norovirus virion, set against a beige background. The different colors represent different regions of the organism’s outer protein shell, or capsid (credit: Unsplash user CDC). Right: BV2 or BV2ΔTMEM30a cells were infected with MNVCR6-HiBiT at an MOI 0.5 in the presence of DMSO, 500 µM GCDCA, or 50 µM C2 ceramide. Sixteen hours post-infection cells were lysed and infection was measured using Nano-Glo HiBiT Lytic Detection System (Promega) post-lysis. Samples are normalized to BV2 cells treated with DMSO.

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Tera Levin @teralevin.bsky.social · Mar 28

💐 To NIH and NSF program officers, and anyone else trying to keep those institutions alive:

Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n

Jeremy Berg @jeremymberg.bsky.social · Mar 28

Just before bedtime last night I got a message from inside NIH which read:

“It’s so, so bad and no one cares (who has any influence)”

I asked “What, in particular?”

My friend responded “Everything”

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International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Mar 26

Co-Chairs, Michael Gale, Jr. and @ramlabuw.bsky.social invite abstract submissions for Cytokines2025. Topics include adaptive immunity, cytokine signaling, interferon stimulated genes, structure- function, and more. Submit: seattle.cytokinesociety.org/call-for-abs...
Deadline is May 18, 2025.

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International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Mar 26

Repost if you're planning to go.

International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Mar 5

Cytokines 2025: Call for abstracts for oral or poster presentations. Topics include adaptive immunity, cytokine signaling, clinical applications, interferon stimulated genes, structure- function of cytokines, and more.

seattle.cytokinesociety.org/call-for-abs...
The deadline is May 18, 2025.

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Cadwell Lab @cadwelllab.bsky.social · Mar 8

Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/...
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n

Rewilding catalyzes maturation of the humoral immune system

Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.

www.science.org

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The American Association of Immunologists @aai.org · Mar 5

Today, immunologists nationwide are making their voices heard! Our AAI Public Policy Fellows are on Capitol Hill, advocating for critical research funding and policies. Join them by participating in our letter-writing campaign: ow.ly/QLvQ50VaY23.

#PPFPHillDay #SciPol #Advocacy

A purple background with text "Join the Biomedical Research Community and Make Your Voice Heard on Capitol Hill!" in smaller capital letters "PROTECT FUNDING FOR BIOMEDICAL RESEARCH!" and images of blood cells, the US Capitol, and lab equipment. "ACT NOW" button.

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Usha Lee McFarling @usha.bsky.social · Mar 5

NEW: In every way, shape, form, actions being taken say ‘don’t go into science,’ Donna Ginther told me as NIH forced to cancel programs to train future researchers. More than 1,000 students, including one who emailed 60 PIs, now scrambling to find positions. www.statnews.com/2025/03/05/t...

Cancellation of NIH summer internships disrupts ‘vital’ training program for U.S. scientists

The NIH cancelled an internship program that gave more than 1,000 college students hands-on research training each summer

www.statnews.com

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Bella Rauch @rauchlab.bsky.social · Mar 4

@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new...

It was signed by over 450 OHSU researchers!

It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.

Opinion: Scientists on how NIH cuts will hurt all Oregonians. - Portland Business Journal

"These cuts will cripple biomedical research and drug development in the U.S. We should be investing more in science, not less."

www.bizjournals.com

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Siyuan Ding @sding88.bsky.social · Mar 3

First post on Bluesky! Excited to share the first paper from our lab in 2025! cell.com/cell-host-mi.... Our study demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice, suggesting the host response also contributes to diarrhea to flush out the virus.

Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea

Hou et al. demonstrate in an infant mouse model that innate immune sensing of enteric viruses induces IFN-λ signaling, which downregulates an apical chloride exchanger that leads to increased intestin...

cell.com

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Stand Up for Science! @standupforscience.bsky.social · Mar 1

Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️

www.rarediseaseday.org

Rare Disease Day 2025 – Raising awareness for people living with rare diseases and their families worldwide.

www.rarediseaseday.org

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International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Jan 18

Mark your calendars Cytokines 2025 Westin Seattle! Abstract submission is opening soon. Make sure to note these important deadlines:
-Abstract Submission deadline: Wednesday 18 June
-Early-Bird Registration Deadline: Friday 25 July
Group room rate $236 seattle.cytokinesociety.org for more details

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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Feb 23

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