Lightnews — Scholar-powered news

Reposted by Irene Beusch

Lori Passmore @lapassmore.bsky.social · 11d

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

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Julius Brennecke @juliusbrennecke.bsky.social · 20d

Love RNA biology?

Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).

PhD student/postdoc position co-supervised by Clemens Plaschka & myself.

DM or email us if you’d like to know more!

@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

Julius Brennecke @juliusbrennecke.bsky.social · 21d

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.

But how does piRNA-guided target interaction translate into silencing?

PhD student Júlia Portell Montserrat has an intriguing answer

www.cell.com/molecular-ce...

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Hanneke Vlaming @hannekevlaming.bsky.social · Sep 4

As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...

PhD position in Gene Regulation

Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!

www.uu.nl

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Irene Beusch @pauletteoctopus.bsky.social · Sep 5

congratulations Hanneke!!! Looking forward to all the cool science coming out of this!!!

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Kara McKinley @karalmckinley.bsky.social · Aug 25

Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!

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DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Jul 25

Our collaboration with Tony Mustoe's lab us out today. MPRA libraries and possible cryptic splicing in MPRA reporters, or reporters in general. The additional novelty here is that such events are controlled or influenced by AU-rich sequences.

www.nature.com/articles/s41...

U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays - Nature Communications

Massively parallel reporter assays (MPRAs) are powerful technologies for measuring the impact of non-coding sequences on gene expression. Here, the authors demonstrate that MPRA reporters often underg...

www.nature.com

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · Jul 21

New from the Pai lab @rti-umasschan.bsky.social

www.biorxiv.org/content/10.1...

Pervasive noise in human splice site selection

RNA splicing has historically been thought to be highly efficient and accurate, with little opportunity for deviation from regulated alternative splicing decisions. This dogma has been challenged by r...

www.biorxiv.org

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Irene Beusch @pauletteoctopus.bsky.social · Jul 11

I guess your(?) bike has some privileges? 😉🥲

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Madeleine Oudin @madeleineoudin.bsky.social · Jul 7

Deadline for applications is this Friday!!!

Madeleine Oudin @madeleineoudin.bsky.social · Jun 24

BME UNITE @bmeunite.bsky.social is launching Year 5 of our Future Faculty Program! BME Faculty candidates from marginalized groups on the job market - apply here by July 11th to present your work and receive mentorship to successfully navigate the academic job market: forms.gle/sVto2GRQauNA...

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Danny IncaRNAto @incarnatolab.bsky.social · Jul 1

The IncaRNAto lab is seeking a motivated #PhD candidate, interested in studying #RNA structural ensemble dynamics in living cells. Here's the link to the vacancy: www.rug.nl/about-ug/wor.... Please share!

Vacatures bij de RUG

www.rug.nl

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Michael Boucher @mjboucher.bsky.social · Jun 11

My postdoctoral work with @hitenmadhani.bsky.social is now online at @cp-cell.bsky.social! We profiled the fitness of >4300 Cryptococcus neoformans deletion strains in >140 conditions, identifying unexpected mammalian-like biology and drivers of fungal pathogenesis.

www.cell.com/cell/fulltex...

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology

The construction and high-precision fitness profiling of a C. neoformans knockout library reveals a high-resolution functional map of its genome and allowed for the identification of fungal analogs of...

www.cell.com

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Irene Beusch @pauletteoctopus.bsky.social · May 27

„AI is unavoidable, and even if a single query is low-impact, governments and companies are now shaping a much larger energy future around AI’s needs.“

Caroline Bartman @cbartman.bsky.social · May 27

this is really interesting about AI and energy use/the environment- I feel it's been hard to get concrete info about this www.technologyreview.com/2025/05/20/1...

We did the math on AI’s energy footprint. Here’s the story you haven’t heard.

The emissions from individual AI text, image, and video queries seem small—until you add up what the industry isn’t tracking and consider where it’s heading next.

www.technologyreview.com

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Ana Fiszbein @anafiszbein.bsky.social · May 16

Very excited to share our new paper out now in
@MolecularCell. We show how U1 snRNP -a well-known splicing factor- regulates the activity of alternative promoters in human cells www.cell.com/molecular-ce...

U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation

Kim et al. uncover a role for U1 snRNP in regulating internal promoter activity. Beyond its canonical role in splicing, U1 snRNP suppresses premature polyadenylation, enabling upstream transcription t...

www.cell.com

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Irene Beusch @pauletteoctopus.bsky.social · May 9

congrats Mike!!! 🎊 I am looking forward to all the cool science from your lab!

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Irene Beusch @pauletteoctopus.bsky.social · May 5

Congrats Dr. Love! 🎊

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Flora Rutaganira @frutag33.bsky.social · Apr 21

Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Flyer for the 2025 Next Generation Faculty Symposium (including QR code in top right corner). This symposium highlights the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences, with a track record of excellence in research, leadership, mentorship, and community engagement. These early career scientists are preparing to launch a faculty search. Applications are due May 30th, 2025.

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Irene Beusch @pauletteoctopus.bsky.social · Apr 21

5EU labelling may have some undesired consequences or effects depending on labelling pulse concentration & duration www.biorxiv.org/content/10.1... #RNAsky

5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins

TDP-43, an essential nucleic acid binding protein and splicing regulator, is broadly disrupted in neurodegeneration. TDP-43 nuclear localization and function depend on the abundance of its nuclear RNA...

www.biorxiv.org

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Eva Kowalinski @kowaeva.bsky.social · Apr 16

Are you a postdoc ready for transition to an independent position? You connect infection biology with cutting-edge structural biology or multimodal imaging? Are you aware of such a colleague?

I am seeking speakers for "The Next Generation in Infection Biology" microsymposium on June 6 2025.

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Irene Beusch @pauletteoctopus.bsky.social · Apr 10

Interesting blog post by Yoseph Barash on tissue specific splicing prediction: biociphers.wordpress.com/2025/04/09/t...

Tissue-specific splicing prediction – What’s in a name, what’s in a claim, and are target functions all the same?

In today’s blog post, I want to discuss some work/claims related to a topic that has been one of my lab’s focus areas – predicting tissue-specific alternative splicing (AS) of RNA. Some backg…

biociphers.wordpress.com

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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · Apr 6

Our PhD program application deadline is near, apply now! In our open present call, we have 25+ fully funded positions for talented Master/MSc students. Start your application by 11 April 2025
training.vbc.ac.at/p...

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Institute of Molecular Biotechnology @imbavienna.bsky.social · Apr 2

Two reminders for aspiring PhD candidates: April 3 is the information session, and April 11 is the application deadline. See below for more info.

Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · Apr 1

Our team is going to answer student questions about our PhD program on 3 April! We have 25+ fully-funded positions in this call. Pass on or share with your colleagues! Sign up here
ow.ly/ptFT50PNJV2

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Irene Beusch @pauletteoctopus.bsky.social · Mar 26

loved the pre-print. looking forward to reading the final manuscript!

Karla Neugebauer @karlaneugebauer.bsky.social · Mar 26

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...

authors.elsevier.com

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Leo Scheller @leoscheller.bsky.social · Mar 13

I’m looking for a BTA and a Postdoc to help set up the Structural Biochemistry group at the Leibniz Institute for Immunotherapy (LIT) in Regensburg 😀.

We apply synthetic biology and protein design to address key challenges in immunotherapy.
lit.eu/work-with-us/
#SynBio #ProteinDesign #Immunotherapy

Work With Us

The LIT welcomes individuals from all life paths and academic backgrounds. If you are passionate about science we could be the perfect home for you.

lit.eu

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Irene Beusch @pauletteoctopus.bsky.social · Mar 14

Cool „news“ from the Hoskins Lab! 🤩 Looking forward to reading them!

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · Mar 13

In happier news, I'm please to share two recent preprints from the lab. These are Ye's and Sierra's first first author publications!

www.biorxiv.org/content/10.1...

and

www.biorxiv.org/content/10.1...

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Reposted by Irene Beusch

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · Mar 13

In happier news, I'm please to share two recent preprints from the lab. These are Ye's and Sierra's first first author publications!

www.biorxiv.org/content/10.1...

and

www.biorxiv.org/content/10.1...

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