Patrick Cherry
@pcherry.bsky.social
MolBio, tech, & culture enthusiasm outlet. Drinking from the fire hose, shouting into the void. he/him👨🔬🧬👨💻🧗♂️🏳️🌈
Senior Scientist at BillionToOne in R&D, working on all things NGS, liquid biopsy, and bioinformatic
https://pcherry.io/
Senior Scientist at BillionToOne in R&D, working on all things NGS, liquid biopsy, and bioinformatic
https://pcherry.io/
Reposted by Patrick Cherry
More than 48 hours into the PG&E meltdown & most of the Muni subway is still down. Right as people get ready for the holiday.
It’s outrageous & unacceptable. It’s time for serious accountability. It’s time for San Francisco to break away from PG&E & create a public utility.
It’s outrageous & unacceptable. It’s time for serious accountability. It’s time for San Francisco to break away from PG&E & create a public utility.
December 23, 2025 at 1:59 AM
More than 48 hours into the PG&E meltdown & most of the Muni subway is still down. Right as people get ready for the holiday.
It’s outrageous & unacceptable. It’s time for serious accountability. It’s time for San Francisco to break away from PG&E & create a public utility.
It’s outrageous & unacceptable. It’s time for serious accountability. It’s time for San Francisco to break away from PG&E & create a public utility.
Reposted by Patrick Cherry
The Sunset is dark & quiet during the blackout.
Pedestrians are using flashlights to get around & restaurants have closed early. Kitchen staff are taking the bus or scootering home.
Patrons are dining by candlelight.
Elsewhere, Waymos are stuck, snarling traffic.
Pedestrians are using flashlights to get around & restaurants have closed early. Kitchen staff are taking the bus or scootering home.
Patrons are dining by candlelight.
Elsewhere, Waymos are stuck, snarling traffic.
December 21, 2025 at 3:14 AM
The Sunset is dark & quiet during the blackout.
Pedestrians are using flashlights to get around & restaurants have closed early. Kitchen staff are taking the bus or scootering home.
Patrons are dining by candlelight.
Elsewhere, Waymos are stuck, snarling traffic.
Pedestrians are using flashlights to get around & restaurants have closed early. Kitchen staff are taking the bus or scootering home.
Patrons are dining by candlelight.
Elsewhere, Waymos are stuck, snarling traffic.
Reposted by Patrick Cherry
Wash, rise, repeat. 🌫️
Tule fog blankets Central Valley, Bay Area. What day is this now?
Tule fog blankets Central Valley, Bay Area. What day is this now?
December 9, 2025 at 5:15 PM
Wash, rise, repeat. 🌫️
Tule fog blankets Central Valley, Bay Area. What day is this now?
Tule fog blankets Central Valley, Bay Area. What day is this now?
Reposted by Patrick Cherry
Love how waymos will just like block the bus for 5 minutes
November 22, 2025 at 8:35 PM
Love how waymos will just like block the bus for 5 minutes
Quick update on #openenrollment HDHPs / HSAs: benefits from employers seem to be broadly getting worse. And this has implications for whether an HDHP will pay off.
pcherry.io/posts/2025_1...
pcherry.io/posts/2025_1...
Open enrolllment: re-evaluating a high-deductible health plan – Frameshift
A blog of indeterminate subject matter and publication frequency from a bioinformatician and data scientist by way of molecular biology.
pcherry.io
November 15, 2025 at 10:54 PM
Quick update on #openenrollment HDHPs / HSAs: benefits from employers seem to be broadly getting worse. And this has implications for whether an HDHP will pay off.
pcherry.io/posts/2025_1...
pcherry.io/posts/2025_1...
Reposted by Patrick Cherry
Imagine buying a payment card network that has a low acceptance rate, especially abroad, and explaining to customers that they should lower the expectations but try anyway
November 14, 2025 at 6:17 AM
Imagine buying a payment card network that has a low acceptance rate, especially abroad, and explaining to customers that they should lower the expectations but try anyway
Reposted by Patrick Cherry
‘Nickname’ is not ‘nick’ + ‘name.’
It was originally ‘ekename.’
‘Eke’ was the Middle English word for “also” or “in addition.”
Since ‘ekename’ began with a vowel, people used ‘an’ before it.
Over time, 'an ekename' became 'a nickname.'
It was originally ‘ekename.’
‘Eke’ was the Middle English word for “also” or “in addition.”
Since ‘ekename’ began with a vowel, people used ‘an’ before it.
Over time, 'an ekename' became 'a nickname.'
November 11, 2025 at 7:05 PM
‘Nickname’ is not ‘nick’ + ‘name.’
It was originally ‘ekename.’
‘Eke’ was the Middle English word for “also” or “in addition.”
Since ‘ekename’ began with a vowel, people used ‘an’ before it.
Over time, 'an ekename' became 'a nickname.'
It was originally ‘ekename.’
‘Eke’ was the Middle English word for “also” or “in addition.”
Since ‘ekename’ began with a vowel, people used ‘an’ before it.
Over time, 'an ekename' became 'a nickname.'
Reposted by Patrick Cherry
As you all know, I have written about the utility of HSAs (health savings accounts): https://pcherry.io/posts/2024_01_02-why_you_should_elect_a_hdhp
Why you should elect a high-deductible health plan – Frameshift
A blog of indeterminate subject matter and publication frequency from a bioinformatician and data scientist by way of molecular biology.
pcherry.io
November 7, 2025 at 7:42 PM
As you all know, I have written about the utility of HSAs (health savings accounts): https://pcherry.io/posts/2024_01_02-why_you_should_elect_a_hdhp
Reposted by Patrick Cherry
Also, NYT has reported on new healthcare costs that are eligible for payment from an HSA: https://archive.ph/oY5b6
November 7, 2025 at 7:41 PM
Also, NYT has reported on new healthcare costs that are eligible for payment from an HSA: https://archive.ph/oY5b6
Reposted by Patrick Cherry
PSA: as you think about open enrollment for next year, Morningstar published a review of the common HSA (health savings account) providers […]
Original post on hachyderm.io
hachyderm.io
November 7, 2025 at 7:39 PM
PSA: as you think about open enrollment for next year, Morningstar published a review of the common HSA (health savings account) providers […]
Reposted by Patrick Cherry
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
October 21, 2025 at 10:49 PM
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
Reposted by Patrick Cherry
The writer who coined the term "enshittification" lays out how things got so bad—and where we go from here—in his new book.
Yes, everything online sucks now—but it doesn’t have to
Ars chats with Cory Doctorow about his new book Enshittification.
arstechnica.com
October 17, 2025 at 7:03 PM
The writer who coined the term "enshittification" lays out how things got so bad—and where we go from here—in his new book.
Me trying to be better at social media
October 17, 2025 at 6:36 PM
Me trying to be better at social media
Reposted by Patrick Cherry
This kind of post always makes me think of all the once-common knowledge of how things worked in my grandparents' generation that's rapidly fading from living memory, just as one day those of us who can see this and say "what?! of course we memorized phone numbers" will die off too.
If anyone needs me I will be in the museum, lying down next to the bog bodies.
October 14, 2025 at 1:19 AM
This kind of post always makes me think of all the once-common knowledge of how things worked in my grandparents' generation that's rapidly fading from living memory, just as one day those of us who can see this and say "what?! of course we memorized phone numbers" will die off too.
Reposted by Patrick Cherry
🟡 M4.8 #earthquake detected 3 km ESE of Berkeley, California at 9/22/2025 2:56:12 AM PDT
This reflects data from the U.S. Geological Survey that is subject to change. Visit the USGS page linked below for the latest #quake information
This reflects data from the U.S. Geological Survey that is subject to change. Visit the USGS page linked below for the latest #quake information
M4.8 - 3 km ESE of Berkeley, California
A magnitude 4.8 earthquake located 3 km ESE of Berkeley, California was detected at 9/22/2025 2:56:12 AM PDT. This information is subject to change. Please visit the USGS event page for up-to-date details.
earthquake.usgs.gov
September 22, 2025 at 9:56 AM
🟡 M4.8 #earthquake detected 3 km ESE of Berkeley, California at 9/22/2025 2:56:12 AM PDT
This reflects data from the U.S. Geological Survey that is subject to change. Visit the USGS page linked below for the latest #quake information
This reflects data from the U.S. Geological Survey that is subject to change. Visit the USGS page linked below for the latest #quake information
Reposted by Patrick Cherry
Becoming increasingly clear we’re gonna have to build a parallel infrastructure for all the media we really love. The reason all of this is happening under the color of law is hyperconsolidation, dissent being traded straight up for merger approval, or fear of harassment.
September 18, 2025 at 12:22 AM
Becoming increasingly clear we’re gonna have to build a parallel infrastructure for all the media we really love. The reason all of this is happening under the color of law is hyperconsolidation, dissent being traded straight up for merger approval, or fear of harassment.
Reposted by Patrick Cherry
an entire generation and everyone coming up after them have essentially been making pirate tv stations for each other on repurposed video game streaming websites for like about a decade now. if we had the money that demonic old baby boomers have poured into nasty jesus creeps you would be astonished
Becoming increasingly clear we’re gonna have to build a parallel infrastructure for all the media we really love. The reason all of this is happening under the color of law is hyperconsolidation, dissent being traded straight up for merger approval, or fear of harassment.
September 18, 2025 at 2:31 AM
an entire generation and everyone coming up after them have essentially been making pirate tv stations for each other on repurposed video game streaming websites for like about a decade now. if we had the money that demonic old baby boomers have poured into nasty jesus creeps you would be astonished
Reposted by Patrick Cherry
tgv 0.1.0 release: github.com/zeqianli/tgv
- Rich CIGAR and base visualization
- Allele frequency visualization
- VCF and BED file support
- Mouse dragging and hovering
- Filter alignment
Now 90% of what I need from IGV can be done in the terminal.
Some interesting behind-the-scenes:
- Rich CIGAR and base visualization
- Allele frequency visualization
- VCF and BED file support
- Mouse dragging and hovering
- Filter alignment
Now 90% of what I need from IGV can be done in the terminal.
Some interesting behind-the-scenes:
September 7, 2025 at 11:47 PM
tgv 0.1.0 release: github.com/zeqianli/tgv
- Rich CIGAR and base visualization
- Allele frequency visualization
- VCF and BED file support
- Mouse dragging and hovering
- Filter alignment
Now 90% of what I need from IGV can be done in the terminal.
Some interesting behind-the-scenes:
- Rich CIGAR and base visualization
- Allele frequency visualization
- VCF and BED file support
- Mouse dragging and hovering
- Filter alignment
Now 90% of what I need from IGV can be done in the terminal.
Some interesting behind-the-scenes:
Reposted by Patrick Cherry
A new review of multicancer early detection tests (MCED). Without any controlled studies in people without symptoms (and at increased risk), they are "not ready for popular use." @annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/epdf/10....
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/epdf/10....
September 15, 2025 at 10:46 PM
A new review of multicancer early detection tests (MCED). Without any controlled studies in people without symptoms (and at increased risk), they are "not ready for popular use." @annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/epdf/10....
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/epdf/10....
Reposted by Patrick Cherry
Hard to think it’ll be in the 80s in San Francisco tomorrow with this thick fog currently out my window, but such is life here in September
www.sfchronicle.com/weather/arti...
www.sfchronicle.com/weather/arti...
San Francisco is about to get very hot. Here’s a timeline
The final full week of summer brings Bay Area heat early, then a chance of midweek storms.
www.sfchronicle.com
September 15, 2025 at 2:17 AM
Hard to think it’ll be in the 80s in San Francisco tomorrow with this thick fog currently out my window, but such is life here in September
www.sfchronicle.com/weather/arti...
www.sfchronicle.com/weather/arti...
Currently obsessed with 'types of plots friends don't let friends make in certain situations': github.com/cxli233/Frie...
GitHub - cxli233/FriendsDontLetFriends: Friends don't let friends make certain types of data visualization - What are they and why are they bad.
Friends don't let friends make certain types of data visualization - What are they and why are they bad. - GitHub - cxli233/FriendsDontLetFriends: Friends don't let friends make certain ty...
github.com
September 14, 2025 at 7:50 PM
Currently obsessed with 'types of plots friends don't let friends make in certain situations': github.com/cxli233/Frie...
Reposted by Patrick Cherry
It's good that we subject every new housing development proposal to a half dozen or more public hearings, so we can collect valuable "local knowledge" like this.
This is an actual opposition:
August 22, 2025 at 11:47 PM
It's good that we subject every new housing development proposal to a half dozen or more public hearings, so we can collect valuable "local knowledge" like this.
Reposted by Patrick Cherry
Sure, we all know it depends on the protein. But why some proteins can be pushed to 40%(!) of total protein like here and others are a pain to get adequately expressed probably involves some real fun unsolved mysteries in RNA biology.
Just how hard can you push cells to make proteins that they don’t need to make?
Cranking Up Protein Expression to the Limit
www.science.org
August 23, 2025 at 4:03 AM
Sure, we all know it depends on the protein. But why some proteins can be pushed to 40%(!) of total protein like here and others are a pain to get adequately expressed probably involves some real fun unsolved mysteries in RNA biology.