Lightnews — Scholar-powered news

Reposted by Quaid Morris

Matthew Hahn @3rdreviewer.bsky.social · 2d

The most important paper in evolutionary biology I'd never heard of:

1/

www.sciencedirect.com/science/arti...

2 20 45

Quaid Morris @quaidmorris.bsky.social · 2d

📌

1

Reposted by Quaid Morris

Tim Wu @superwuster.bsky.social · 5d

Finalized my 2025 book tour!

Coming through New York, DC, Chicago, Toronto, San Francisco, Los Angeles, London, Oxford and Cambridge. Click here for details:
timwu.net#booktour

3 8

Reposted by Quaid Morris

ralucagordan.bsky.social @ralucagordan.bsky.social · 6d

I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...

DNA mutagenesis driven by transcription factor competition with mismatch repair

Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

www.cell.com

2 13 57

Reposted by Quaid Morris

Max Kozlov @maxkozlov.bsky.social · 8d

Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.

“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.

www.nature.com/articles/d41...

NIH races to spend its 2025 grant money — but fewer projects win funding

Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.

www.nature.com

4 120 390

Quaid Morris @quaidmorris.bsky.social · 9d

Segmentation fault (core dumped)

1 3

Reposted by Quaid Morris

Markus Hafner @markushafnerrna.bsky.social · 11d

www.biorxiv.org/content/10.1...

Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.

The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3'UTRs

The RNA-binding proteins DND1 and NANOS3 are essential for primordial germ cell survival. Their co-immunoprecipitation and overlapping loss-of-function phenotypes suggest joint function, yet how they ...

www.biorxiv.org

11 22

Reposted by Quaid Morris

Craig Kaplan @triggerloop.bsky.social · 13d

This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...

Collective homeostasis of condensation-prone proteins via their mRNAs - Nature

The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.

www.nature.com

11 30

Reposted by Quaid Morris

HowDoYou Guide @howdoyou.guide · 13d

Hi @npr.org! We worked late tonight putting together this handy pocket guide!

It doesn't address road design issues, but if we're going to educate road users, we should include drivers.

It's the size of a folded business card. Print it, fold it, put it in your wallet!

"How Do You Avoid Hitting People With Your Car" pocket guide. Instructs readers to Watch the Road and Slow Down. Further text humorously insists that watching the road and slowing down are indeed important.

41 1.1K 2.7K

Reposted by Quaid Morris

Sofya Garushyants @garushyants.bsky.social · 23d

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

1 91 70

Quaid Morris @quaidmorris.bsky.social · 21d

Nice work, thanks for sharing!

Reposted by Quaid Morris

Piali Sengupta @senguptalab.bsky.social · 23d

A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails.
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!

5 94 430

Reposted by Quaid Morris

David A Knowles @davidaknowles.bsky.social · 28d

YouTube link for MLCB2025 is up! Starting in 30 min. www.youtube.com/live/19I7xTh...

Machine Learning in Computational Biology 2025

YouTube video by Machine Learning in Computational Biology

www.youtube.com

1 5 19

Reposted by Quaid Morris

Peter Koo @pkoo562.bsky.social · 28d

2025 Machine Learning in Computational Biology (#MLCB) meeting starts TODAY (9/10) at 9:30a (EST) at the NY Genome Center in NYC!

We have a great lineup of keynotes, contributed talks, and posters today and tomorrow

Schedule: mlcb.org/schedule

Join for free via livestream: m.youtube.com/@mlcbconf

MLCB - Schedule

The in-person component will be held at the New York Genome Center, 101 6th Ave, New York, NY 10013. All times below are Eastern Time.

mlcb.org

1 7 13

Quaid Morris @quaidmorris.bsky.social · Sep 3

FYI, if your code is written in MATLAB, your 2025 manuscript will not be read by me

1 6

Reposted by Quaid Morris

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Aug 28

If you like transcription regulation and its mechanisms, this WIP list is for you.

I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.

go.bsky.app/8vTgeXB

46 41 92

Reposted by Quaid Morris

Martin Smith @martinalexsmith.bsky.social · Aug 25

RNA is far more than a messenger.

Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.

But predicting #RNA structure from sequence is still extremely difficult.

In our recently published paper in @narjournal.bsky.social we present a way forward.

🧵 ⤵️

1 18 57

Reposted by Quaid Morris

Ander Diaz-Navarro @dn-ander.bsky.social · Aug 21

Thrilled to see my postdoctoral work published in @cellpress.bsky.social

OncoGAN generates simulated genomes to train genomic analysis tools —without the confidentiality risks of real genomes.

News story: t.co/J9QJZInPOE
Paper: t.co/ygEjM5vuGZ

#Genomics #Cancer #AI #Bioinformatics

https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00225-3

t.co

1 2 9

Quaid Morris @quaidmorris.bsky.social · Aug 21

Most animals are dinosaurs, geese or sheep for our 19 month old

1 1

Reposted by Quaid Morris

Selene FeRNAndez @selfdz.bsky.social · Aug 16

Interested in #RNA research in the Asia-Pacific region? Join us at the first Asia RNA Club Symposium 2025!

🗓️ Nov 3-5, 2025
📍Seoul National University, Seoul, 🇰🇷

Submit your abstract by Aug 22nd
Register by Oct 10th

More info: asiarnaclub.org

#AsiaRNA2025 #RNASky @rnasociety.bsky.social

🔄🙏🏽

Tile promoting the Asia RNA Club Symposium 2025

2 3

Quaid Morris @quaidmorris.bsky.social · Aug 4

I wonder whether it is due to high reviewer load and high trainee-only reviewing

1

Quaid Morris @quaidmorris.bsky.social · Aug 4

D’oh

1

Quaid Morris @quaidmorris.bsky.social · Aug 4

That's what the peanut butter is for

1 1

Reposted by Quaid Morris

Eileen Furlong @eileen-furlong.bsky.social · Jul 30

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader - Genome Biology Unit

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

embl.wd103.myworkdayjobs.com

230 190

Reposted by Quaid Morris

The Francis Crick Institute @crick.ac.uk · Jul 29

Meet Jernej Ule (@ulelab.bsky.social) and Ben Blencowe, who set up the Brain RNA Regulatory Networks satellite lab here at the Crick.

We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy.

www.crick.ac.uk/news/2025-07...

Introducing... Jernej Ule and Ben Blencowe

We spoke to Jernej Ule and Ben Blencowe, who recently set up the Brain RNA Regulatory Networks satellite lab here at the Crick.

www.crick.ac.uk

4 15