By leveraging the power of pretrained DNA foundation models, SegmentNT achieves performant genome annotation through segmenting different genic and regulatory elements.

The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucleotide residues, the RNome, encompassing over 180 distinct modifications across organisms, with at least 50 in humans, is increasingly recognized. These modifications play critical roles in regulating RNA structure, stability, and function, yet the rules linking their precise locations to biological outcomes remain poorly defined. The Human RNome Project aims to map all RNA modifications, build essential resources, and harness new technologies to transform RNA biology, therapeutic development, agriculture, and even data storage.

Will the labs devour the apps that run on their models?

Nanopore sequencing enables real-time long-read DNA sequencing with reads exceeding 10 kilobases, but inherent error rates of 12-15 percent present significant computational challenges for read alignm...

Big complex molecules are the unique stuff of life. This is how they work

Abstract. Polyadenylation is a dynamic process that is important in cellular physiology, which has implications in messenger RNA decay rates, translation e

Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...

Fake clock, new GC, flight recorder and more.

Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the

Abstract. Phylodynamic methods provide a coherent framework for the inference of population parameters directly from genetic data. They are an important to