Scott Rush
@scottrush.bsky.social
Scientist interested in structural biology, vaccine design, antibodies, protein engineering… pretty much everything
Reposted by Scott Rush
Now online! Generation of antigen-specific paired-chain antibodies using large language models
Generation of antigen-specific paired-chain antibodies using large language models
MAGE is a sequence-based protein language model designed to generate diverse human antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A. This AI-driven approach addresses traditional limitations by enabling efficient, target-agnostic antibody design with experimentally validated binding specificity.
dlvr.it
November 4, 2025 at 11:38 PM
Now online! Generation of antigen-specific paired-chain antibodies using large language models
Reposted by Scott Rush
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Reposted by Scott Rush
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1
November 1, 2025 at 10:16 PM
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1
Reposted by Scott Rush
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
October 30, 2025 at 3:21 AM
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Reposted by Scott Rush
Antibodies blocking PlGF or VEGF interactions with the NRP1 receptormediate anti-proliferative effects https://www.biorxiv.org/content/10.1101/2025.10.25.684565v1
October 27, 2025 at 2:46 AM
Antibodies blocking PlGF or VEGF interactions with the NRP1 receptormediate anti-proliferative effects https://www.biorxiv.org/content/10.1101/2025.10.25.684565v1
Reposted by Scott Rush
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
October 24, 2025 at 8:11 AM
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
Reposted by Scott Rush
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 15, 2025 at 2:08 PM
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Reposted by Scott Rush
Online now: Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
The Pfs230:Pfs48/45 complex is the target of leading anti-malaria transmission-blocking vaccine candidates, yet its molecular assembly is poorly understood. Bekkering, Yoo, Hailemariam, et al. determined the cryo-electron microscopy structure of the endogenous Pfs230:Pfs48/45 complex bound to six potent transmission-blocking antibodies, providing a structural basis for antibody inhibition and blueprints for the design of next-generation malaria vaccines.
dlvr.it
October 9, 2025 at 2:49 PM
Online now: Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
Reposted by Scott Rush
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
UT Austin has a new “genius grant” recipient!
Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation.
#TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social
cns.utexas.edu/news/accolad...
Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation.
#TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social
cns.utexas.edu/news/accolad...
Virus Slayer Awarded ‘Genius Grant’ by MacArthur Foundation
The award recognizes Jason McLellan’s work to investigate how viruses infect our cells and to develop new treatments for infectious disease.
cns.utexas.edu
October 8, 2025 at 7:59 PM
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
Reposted by Scott Rush
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
September 29, 2025 at 2:58 PM
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
Reposted by Scott Rush
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:08 PM
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
Reposted by Scott Rush
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
September 15, 2025 at 9:37 AM
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Reposted by Scott Rush
Structural Basis for Childhood Antibody Recognition of The Human Metapneumovirus Fusion Protein https://www.biorxiv.org/content/10.1101/2025.08.29.673069v1
September 4, 2025 at 1:17 AM
Structural Basis for Childhood Antibody Recognition of The Human Metapneumovirus Fusion Protein https://www.biorxiv.org/content/10.1101/2025.08.29.673069v1
Reposted by Scott Rush
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
August 19, 2025 at 6:24 PM
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
Reposted by Scott Rush
Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social https://tinyurl.com/cryo2025
Austrian Cryo-EM Symposium
cryoem-symposium.pages.ist.ac.at
July 25, 2025 at 3:45 PM
Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social https://tinyurl.com/cryo2025
Reposted by Scott Rush
🚨 New paper alert! 🚨
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses
Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influe...
bit.ly
August 4, 2025 at 5:48 PM
🚨 New paper alert! 🚨
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
Reposted by Scott Rush
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
August 1, 2025 at 9:22 PM
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Reposted by Scott Rush
Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies:
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Predicting the translation efficiency of messenger RNA in mammalian cells
Nature Biotechnology - A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.
url.de.m.mimecastprotect.com
July 25, 2025 at 1:37 PM
Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies:
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Reposted by Scott Rush
Reposted by Scott Rush
New in @science.org
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus
The 2.8-Å resolution structure is presented for a chimeric construct of an emerging tick-borne flavivirus, Powassan virus.
www.science.org
July 9, 2025 at 8:11 PM
New in @science.org
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
Reposted by Scott Rush
In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
July 8, 2025 at 5:33 AM
In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
Reposted by Scott Rush
We're hiring a postdoc!
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
Postdoc Research Group Schur
The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID.
Our Group
...
ista.ac.at
July 7, 2025 at 9:21 AM
We're hiring a postdoc!
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
Reposted by Scott Rush
Check our recent works for near-atomic resolution structure of ANDV tetramers by cryoEM!
In addition, we imaged rVSVs displaying ANDV and CCHFV glycoproteins (provided by @chandranlab.bsky.social) and worked with @jesseerasmus.bsky.social and colleagues at HDT Bio to assess the VLPs' immunogenicity in mice via repRNA. Thanks to all authors for their contributions!
June 18, 2025 at 2:39 PM
Check our recent works for near-atomic resolution structure of ANDV tetramers by cryoEM!
Reposted by Scott Rush
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
June 18, 2025 at 2:24 PM
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
Reposted by Scott Rush
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
June 6, 2025 at 1:46 PM
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀