Lightnews — Scholar-powered news

Reposted by Timothée Lionnet

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

7 100 190

Reposted by Timothée Lionnet

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 6d

A printed human genome (displayed in the 'Medicine Now' room at the Wellcome Collection, London)

1 1 7

Timothée Lionnet @successprocess.bsky.social · 9d

tl;dr it's all downhill from here

Julia M. Rohrer @dingdingpeng.the100.ci · 9d

Looks like my favorite paper on the age trajectory of happiness is finally out!!! So happy for the authors. Go check it out, it’s great.

1

Reposted by Timothée Lionnet

Christophe 🔬 L @christlet.bsky.social · 13d

#FluorescenceFriday: getting ready for #GEF25, playing with Ciarán's stunning ExM data

6 20 120

Reposted by Timothée Lionnet

Lucas Farnung @lucas.farnunglab.com · 13d

🚀 Ordering lab supplies just got way easier in our lab.
We built a workflow (github.com/farnunglab/N...) where tapping an NFC tag on a reagent bottle automatically triggers an order request in Quartzy. No more scribbling notes or hunting for a computer. Here’s how 👇

1 9 29

Reposted by Timothée Lionnet

Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 13d

Back to work on #bigvolumebrowser, I've added the import of point clouds that change over time. The test data generation was a pleasant detour into the world of attractors (Thomas' cyclically symmetric is shown).

5 24

Timothée Lionnet @successprocess.bsky.social · 13d

we could learn from other communities which have used preprints for longer - their preprints are usually much better formatted and easier to read

paveltomancak.bsky.social @paveltomancak.bsky.social · 13d

If we are to read exclusively pre-prints in the future, can we at least require to inline Figures with text? The pre-print format is all geared towards peer review, not the convenient presentation of the science.

2

Reposted by Timothée Lionnet

Drug Monkey @drugmonkey.bsky.social · 13d

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

www.science.org

5 250 410

Reposted by Timothée Lionnet

John Greally @greally.bsky.social · 13d

Seven years.
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.

#EpigeneticsBook
@cshlpress.bsky.social

6 14 150

Reposted by Timothée Lionnet

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 15d

Emergence of activation or repression in transcriptional control under a fixed molecular context www.pnas.org/doi/10.1073/...

Emergence of activation or repression in transcriptional control under a fixed molecular context | PNAS

Transcription factors (TFs) can be both activators and repressors of gene transcription. This can manifest as “duality,” where the transcriptional ...

www.pnas.org

8 27

Reposted by Timothée Lionnet

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 14d

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

7 50 100

Timothée Lionnet @successprocess.bsky.social · 14d

www.bbc.com/news/article...

www.bbc.com

3

Reposted by Timothée Lionnet

Serena Sanulli Lab at Stanford Genetics @serenasanulli.bsky.social · 16d

Excited to share our first preprint! We developed an image-based pooled screen to uncover regulators of HP1 condensates and discovered a link with intronic RNA and RNA processing. 👏 Congrats to all authors, especially Matthew, Shaopu & Chris!

bioRxiv Genetics @biorxiv-genetic.bsky.social · 17d

An image-based CRISPR screen reveals splicing-mediated control of HP1α condensates https://www.biorxiv.org/content/10.1101/2025.09.21.676939v1

1 8 21

Reposted by Timothée Lionnet

Slavov Laboratory @slavovlab.bsky.social · 18d

We quantified mRNA abundance, translation, protein abundance, protein degradation and cell growth across thousands of single cells from a mammalian tissue.

The results revealed 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 regulation & 𝐬𝐢𝐦𝐩𝐥𝐞 organizing principles:

www.biorxiv.org/content/10.1...

🧵

1 12 33

Reposted by Timothée Lionnet

Anders Sejr Hansen @andersshansen.bsky.social · 17d

Asking BlueSky for help: For a review, I am trying to accurately credit the first paper that measured pairwise 3D distances between 2 pieces of DNA on the same chromosome (or cosmid). Is Trask 1989 the first?
I know of earlier single-locus papers (1982).
www.sciencedirect.com/science/arti...

5 34 76

Reposted by Timothée Lionnet

siddhartha jena @epijenatics.bsky.social · 27d

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

1 32 82

Reposted by Timothée Lionnet

Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 28d

Really enjoying reading this primer on single particle tracking #microscopy by @svanteeffelen.bsky.social and colleagues www.nature.com/articles/s43... (pdf on Sven's website)

A guide to single-particle tracking - Nature Reviews Methods Primers

Single-particle tracking is a method for analysing different motion behaviours of individual proteins and protein complexes in live cells. This Primer outlines the experimental setup and labelling tec...

www.nature.com

2 14 35

Reposted by Timothée Lionnet

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 28d

👀

Multiple human enhancer RNAs contain long translated open reading frames

genesdev.cshlp.org/content/earl...

Multiple human enhancer RNAs contain long translated open reading frames

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

5 8 40

Reposted by Timothée Lionnet

Pedro Rocha @pedroprocha.bsky.social · Sep 8

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

24 23

Reposted by Timothée Lionnet

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · Sep 8

Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!

FMI science @fmiscience.bsky.social · Sep 8

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

12 20

Timothée Lionnet @successprocess.bsky.social · Sep 2

looks like this would only apply for institutions with endowments > 500k per student? www.law.cornell.edu/uscode/text/...

26 U.S. Code § 4968 - Excise tax based on investment income of private colleges and universities

www.law.cornell.edu

1 3

Reposted by Timothée Lionnet

Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · Sep 1

🧪 And House appropriators say: no cuts to NIH budget!

House subcommittee version just came out (link below). Holds NIH flat at $48 billion.

To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.

YOUR VOICE MATTERS!!

5 180 470

Timothée Lionnet @successprocess.bsky.social · Aug 31

I just love the esthetics of those old school drawn figures of cells

2

Reposted by Timothée Lionnet

Lennart Hilbert @lennarthilbert.bsky.social · Aug 31

Fine structural organization of the interphase nucleus in some mammalian cells, Monneron & Bernard, 1969

Gotta love these classic papers about nuclear architecture. In hindsight, all that we understand and discover today was already contained in their images.

www.sciencedirect.com/science/arti...

3 9 41

Reposted by Timothée Lionnet

Trcek Lab @trceklab.bsky.social · Aug 30

New paper from the Trcek lab, with Siran Tian as the lead author - congratulations Siran!: www.nature.com/articles/s41...

Controlling intermolecular base pairing in Drosophila germ granules by mRNA folding and its implications in fly development - Nature Communications

Tian et al. show that RNA folding limits extensive base pairing among mRNAs in Drosophila germ granules. Instead, mRNAs interact via scattered bases exposed on the surface of folded RNAs, which may pr...

www.nature.com

1 8 18