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Reposted by Jotham Suez (SuezLab@JHU)

Nature Microbiology @natmicrobiol.nature.com · Aug 15

#NewResearch

Prion-like proteins in Escherichia coli trigger an abortive infection mechanism in response to phage infection—a process similar to amyloid-mediated immune signalling in fungi and animals.

#MicroSky 🦠

www.nature.com/articles/s41...

Characterization of an amyloid-based antiphage defence system in Escherichia coli - Nature Microbiology

Prion-like proteins in Escherichia coli trigger an abortive infection mechanism in response to phage infection—a process similar to amyloid-mediated immune signalling in fungi and animals.

www.nature.com

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Reposted by Jotham Suez (SuezLab@JHU)

Sean Gibbons 🦠💩 @gibbological.bsky.social · Aug 6

💥Personalized C. difficile colonization risk prediction and probiotic therapy assessment in the human gut💥

I'm very excited about this work, driven by Alex Carr & co-supervised by @cdiener.com

@cp-cellsystems.bsky.social @isbscience.org @nitinbaliga.bsky.social

www.cell.com/cell-systems...

🧵...

Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut

Carr et al. show how microbial community-scale metabolic models (MCMMs) predict personalized Clostridioides difficile colonization risk and probiotic efficacy. MCMMs reveal key metabolic strategies ex...

www.cell.com

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Reposted by Jotham Suez (SuezLab@JHU)

Tal Korem @tkorem.bsky.social · Aug 7

We are hiring a postdoc - come work with us (www.koremlab.science) at the intersection of #microbiome, data science, and women's health!
Message or email me if interested. 🖥️ 🧬

Korem Lab - Microbiome Systems Biology @ Columbia | New York, USA

We apply systems biology approaches to decipher the metabolic interactions between the microbiome and its human host in diverse clinical settings, aiming towards personalized microbiome-based therapeu...

www.koremlab.science

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Reposted by Jotham Suez (SuezLab@JHU)

Eugen Pfeifer @eugenpfeifer.bsky.social · Jul 28

Excited 🥳 to share our latest work on gut phages!
Big thanks to @epcrocha.bsky.social, Erick D, Camille d'H, @fplazaonate.bsky.social, Quentin LB, and all others involved for support and contributions! 🙌
Out in Cell Reports @cp-cellreports.bsky.social
doi.org/10.1016/j.ce...
Here's what we found 🤓

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Jotham Suez (SuezLab@JHU) @suez.bsky.social · Jul 31

Really cool work, congrats!

Curious what this would say about our Cell 2018 data with humans taking antibiotics & probiotics 🙂

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Jotham Suez (SuezLab@JHU) @suez.bsky.social · Jul 31

Really cool work, congrats Gechlang, Sean, and team! 👏🏽

Sean Gibbons 🦠💩 @gibbological.bsky.social · Jul 31

You can get an accurate estimate of total bacterial biomass from stool metagenomes by simply normalizing by host read count, without needing any additional measurements.

Excellent work by UW Master's student Gechlang Tang in @asm.org #mSystems Journal.

journals.asm.org/doi/10.1128/...
🧵

Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization | mSystems

In this study, we asked whether normalization by host reads alone was sufficient to estimate absolute bacterial biomass directly from stool metagenomic data, without the need for synthetic spike-ins, ...

journals.asm.org

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Jotham Suez (SuezLab@JHU) @suez.bsky.social · Jul 31

We need more studies causally linking sucralose-altered human microbiomes to immunotherapy efficacy to guide clinical decision-making.

But there are already good reasons to consider reducing the intake of artificial sweeteners (and sugar!).

Congrats on an important and interesting work!

fin/🧵

Jotham Suez (SuezLab@JHU) @suez.bsky.social · Jul 31

Their data in humans are observational and extend to other non-nutritive sweeteners as well. These observations are supported by extensive preclinical work, including microbiome transplants to establish a causal role for the sucralose-altered microbiome in disrupting cancer immunotherapy.

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Jotham Suez (SuezLab@JHU) @suez.bsky.social · Jul 31

We've shown before that sucralose alters the human microbiome (tinyurl.com/SuezCell22), and we know that the microbiome can impact responsiveness to cancer immunotherapy.

1+1=...? Yes!

The authors show that sucralose-elicited changes can disrupt immunotherapy efficacy.

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Jotham Suez (SuezLab@JHU) @suez.bsky.social · Jul 31

Sucralose may interfere with cancer immunotherapy - exciting and important new research from @overacrelab.bsky.social in @theaacr.bsky.social!

aacrjournals.org/cancerdiscov...

(AI-rendered illustration of the article's title)

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AI-rendered illustration of the article's title: Sucralose consumption ablates cancer immunotherapy response through microbiome disruption

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Reposted by Jotham Suez (SuezLab@JHU)

Jack A Gilbert @gilbertjacka.bsky.social · Jul 17

🌿💡 Just dropped: our 4‑bug SynCom eats 8 herbicides (up to 99 % gone in a month) and revs up soil carbon metabolism. Microbes doing double duty for cleaner, richer black soils. Check the iMeta paper: onlinelibrary.wiley.com/doi/full/10.... #SoilSci #Bioremediation

SynCom‐mediated herbicide degradation activates microbial carbon metabolism in soils

Extensive herbicide residues in the black soil of northeastern China are considered a significant agricultural pollution threat, yet effective bioremediation of this complex and persistent mixture re...

onlinelibrary.wiley.com

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Reposted by Jotham Suez (SuezLab@JHU)

Jacobo de la Cuesta-Zuluaga @jdlcz.bsky.social · Jul 16

It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...

www.nature.com

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Reposted by Jotham Suez (SuezLab@JHU)

Eric Topol @erictopol.bsky.social · Jul 16

A gut microbiome metabolite promotes atherosclerosis by hijacking the immune system
@nature.com
nature.com/articles/s41...
www.nature.com/articles/d41...

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Reposted by Jotham Suez (SuezLab@JHU)

Vaughn Cooper @vscooper.micropopbio.org · Jul 14

To learn more about SeqCoast including direct orders with transparent pricing, visit seqcoast.com

Sequence smarter, discover more
(said in a New Hampshire accent 😉)

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Reposted by Jotham Suez (SuezLab@JHU)

hanseulkim.bsky.social @hanseulkim.bsky.social · Jul 3

⚡🦠I'm very excited to share our latest work on the gut microbiome and metabolic dysfunction-associated steatotic liver disease (MASLD) is published in @natmetabolism.nature.com, with @hutlab.bsky.social & @longnguyen.bsky.social!

🔗Check out the paper here:
www.nature.com/articles/s42...

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Reposted by Jotham Suez (SuezLab@JHU)

Tami Lieberman @contaminatedsci.bsky.social · Jun 30

Our paper demonstrating that within-species warfare interactions are ecologically important on human skin is now published in Nature Micro! www.nature.com/articles/s41...

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Reposted by Jotham Suez (SuezLab@JHU)

Nature Portfolio @natureportfolio.nature.com · Jun 9

Applications are now open for the 2026 Takeda Innovators in Science Award with Nature. Early-career researchers in GI & inflammatory disease, neuroscience or oncology: Win a share of US$400K and earn global recognition. Apply today: go.nature.com/4jBp3oM #Academicsky

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Reposted by Jotham Suez (SuezLab@JHU)

Neil Renic @ncrenic.bsky.social · Jun 18

I am once again pitching my romantic comedy:

- two academics start dating
- discover they are each other's terrible reviewer
- hijinks ensue

Working title: Love is Double-Blind

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Reposted by Jotham Suez (SuezLab@JHU)

Denis Wirtz @deniswirtz.bsky.social · Jun 2

Research Saves Lives

At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc.

Check it out: researchsaveslives.jhu.edu

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Reposted by Jotham Suez (SuezLab@JHU)

lizkellogg.bsky.social @lizkellogg.bsky.social · Jun 2

our lab is blessed to have 3 new postdoctoral fellow positions. we would welcome scientists interested in...

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Reposted by Jotham Suez (SuezLab@JHU)

CosmicRami 🏳️‍🌈🏳️‍⚧️ @cosmicrami.com · Jun 1

Well, it being #Pride month and all, let's kick things off with a couple of starter packs I haven't shared in a while ...

The awesome folks at @prideinstem.bsky.social have made it super easy for you to queerify your TL, by following the good folks in these three starter packs:

1/2 🏳️‍🌈🏳️‍⚧️

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Jotham Suez (SuezLab@JHU) @suez.bsky.social · May 30

. @haleybiont.bsky.social have fun? 🙂

Nature Microbiology @natmicrobiol.nature.com · May 6

🚨 Out now!

Chronostrain - a method to profile low abundance strains in longitudinal microbiome samples 🦠💻

@travis.gibsonlab.io @younhk.bsky.social @gibsonlab.io @harvardmed.bsky.social @broadinstitute.org

#MicroSky 🦠 #MicrobiomeSky

www.nature.com/articles/s41...

Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain - Nature Microbiology

ChronoStrain accurately profiles low-abundance strains in longitudinal samples by jointly modelling nucleotide sequencing errors, strain presence/absence and the temporal information associated with e...

www.nature.com

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Reposted by Jotham Suez (SuezLab@JHU)

SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · May 27

Antibiotics disrupt gut microbes, but what about their viruses?
A new study finds that gut phages crash, bloom, and bounce back after antibiotics, helping restore microbial balance via kill-the-winner dynamics.
✍️ @eugenpfeifer.bsky.social & coll.
📖 shorturl.at/AtafX
#MicroSky #AMR

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Reposted by Jotham Suez (SuezLab@JHU)

Meghan Azad, PhD @meghanazad.bsky.social · May 22

✨ Job Alert: Bioinformatician & Data Manager ✨

Support our research on milk, microbiomes and maternal & infant health!

📍Remote (within Canada) or In-person
💵 $74K–$107K + benefits
⏱️ Full Time
🎓 MSc & 4+ yrs experience req'd
Apply at: umanitoba.ca/careers/ (#38485)

Pls share! 🙏🏻🧪

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Reposted by Jotham Suez (SuezLab@JHU)

Saheli Sadanand @sahelisadanand.bsky.social · May 19

📣 #NatureMedicine is hiring a new editor with expertise in #AI, #DigitalMedicine and/or Health #Informatics! This job is open to applicants in NYC 🗽and Milano 🎭! Deadline is Fri, May 30th. Please share!
springernature.wd3.myworkdayjobs.com/SpringerNatu...

cc: @natureportfolio.nature.com

Associate or Senior Editor, Nature Medicine, Digital Medicine and Artificial Intelligence 

Job Title: Associate or a Senior, Nature Medicine (Digital Medicine and Artificial Intelligence) Location: New York or Milan (Hybrid Working) Application Deadline: May 30, 2025 About Springer Nature G...

springernature.wd3.myworkdayjobs.com

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