It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A common approach in mammary gland biology is the evaluation of branching morphogenesis to characterize the role of developmental, physiological and molecular perturbations on branching tissue invasion, growth, and maintenance. Yet, the field still lacks a fully open-sourced, quantitative framework to analyze whole-mount mammary tissue images, as a commonly utilized methodology. Here, we present MaGNet (Mammary Gland Network analysis tool), a method that leverages network theory to characterize key features of ductal branching during mammary gland development. Applying this pipeline to mammary gland images captured at three pubertal timepoints, we achieved reproducible quantification of ductal tree expansion across development. In addition, this network analysis pipeline captures ductal expansion induced by pregnancy hormones. By providing open-source tools to the research community, this method may increase reproducibility and broad applicability across diverse organ systems, model organisms, and developmental stages.

Centrosome amplification (CA) is a hallmark of epithelial cancers, yet its spatial complexity and phenotypic heterogeneity remain poorly resolved due to limitations in conventional image analysis. We ...

Centrosome amplification (CA) is a hallmark of epithelial cancers, yet its spatial complexity and phenotypic heterogeneity remain poorly resolved due to limitations in conventional image analysis. We ...

A generalist high-throughput deep learning framework for centrosome phenotyping at spatial and single-cell resolution in heterogeneous tissues - SKELAB/CenSegNet

Centrosome amplification (CA) is a hallmark of epithelial cancers, yet its spatial complexity and phenotypic heterogeneity remain poorly resolved due to limitations in conventional image analysis. We ...

Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...

Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Publishing your poster creates a verifiable and citable record of your work. It also protects you from bad actors — the evidence will be…

Apply for the Research Associate in Programmable Plant Immunity role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

يكشف الباحث الجزائري في مجالات التكنولوجيات الحيوية بجامعة ساوثهامبتون بالمملكة المتحدة، البروفيسور صالح إلياس، في هذا الحوار مع النصر، عن رغبته في العودة إلى الوطن من أجل نقل الخبرات التي اكتسبها في ...