Tom Mumford
@trmumford.bsky.social
Science (optogenetics, fluorescent reporters, fusion oncoproteins, post-doc @bugajlab.bsky.social), running, caps hockey, sixers, bass guitar (he/him)
📍Philly
📍Philly
Reposted by Tom Mumford
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social.
www.biorxiv.org/content/10.6...
👇
www.biorxiv.org/content/10.6...
👇
December 17, 2025 at 3:10 PM
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social.
www.biorxiv.org/content/10.6...
👇
www.biorxiv.org/content/10.6...
👇
Reposted by Tom Mumford
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Reposted by Tom Mumford
#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!
December 8, 2025 at 12:12 PM
#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!
vousy and oscar :)
December 4, 2025 at 6:03 PM
vousy and oscar :)
Reposted by Tom Mumford
the benoit blanc murder mystery industrial complex is doing really well but won't fully take off until we admit the franchise needs a recurring blofeld type villain played by tony shalhoub
November 30, 2025 at 2:10 AM
the benoit blanc murder mystery industrial complex is doing really well but won't fully take off until we admit the franchise needs a recurring blofeld type villain played by tony shalhoub
Reposted by Tom Mumford
On a related note, I wrote today at @libertyballers.bsky.social about how indispensible Andre Drummond has been for the Sixers in the early going.
The Big Penguin is back! And bombing 3s now!
www.libertyballers.com/76ers-analys...
The Big Penguin is back! And bombing 3s now!
www.libertyballers.com/76ers-analys...
November 19, 2025 at 8:32 PM
On a related note, I wrote today at @libertyballers.bsky.social about how indispensible Andre Drummond has been for the Sixers in the early going.
The Big Penguin is back! And bombing 3s now!
www.libertyballers.com/76ers-analys...
The Big Penguin is back! And bombing 3s now!
www.libertyballers.com/76ers-analys...
Reposted by Tom Mumford
November 19, 2025 at 1:00 PM
Reposted by Tom Mumford
Good news: If you would like to watch Ricky Jay and His 52 Assistants on YouTube I have done a painstaking 4k upscale of this. www.youtube.com/watch?v=x0gW...
November 17, 2025 at 2:06 AM
Good news: If you would like to watch Ricky Jay and His 52 Assistants on YouTube I have done a painstaking 4k upscale of this. www.youtube.com/watch?v=x0gW...
Reposted by Tom Mumford
Boy Mamdani's race is really a vivid reminder that anti-Islamic bigotry is 100% accepted in US public discourse. People don't even bother dog whistling, it's just right out in the open.
November 4, 2025 at 8:09 PM
Boy Mamdani's race is really a vivid reminder that anti-Islamic bigotry is 100% accepted in US public discourse. People don't even bother dog whistling, it's just right out in the open.
Reposted by Tom Mumford
It appears Adem Bona didn’t fulfill his (ongoing) rookie duties — which resulted in his tire being removed and popcorn being filled in his car.
Vibes seem great with the Sixers!
Vibes seem great with the Sixers!
October 16, 2025 at 6:39 PM
It appears Adem Bona didn’t fulfill his (ongoing) rookie duties — which resulted in his tire being removed and popcorn being filled in his car.
Vibes seem great with the Sixers!
Vibes seem great with the Sixers!
Reposted by Tom Mumford
Special education isn't a "nice thing to have." It isn't "charity" or doing something to make us feel better. It is a right. The right to a Free Appropriate Public Education is codified in the Individuals with Disabilities Education Act, signed by a Republican president.
U.S. Department of Education fired nearly everyone in the Office of Special Education and Rehabilitative Services in a wave of new layoffs that began Friday, according to the union representing the agency's employees. www.usatoday.com/story/news/e...
Education Department wipes out special ed office in shutdown layoffs, union says
The Education Department laid off nearly everyone at the Office of Special Education and Rehabilitative Services.
www.usatoday.com
October 13, 2025 at 2:19 PM
Special education isn't a "nice thing to have." It isn't "charity" or doing something to make us feel better. It is a right. The right to a Free Appropriate Public Education is codified in the Individuals with Disabilities Education Act, signed by a Republican president.
Reposted by Tom Mumford
there is no peace to be made with the treadmill, it is the devil’s tool
September 27, 2025 at 2:43 AM
there is no peace to be made with the treadmill, it is the devil’s tool
Reposted by Tom Mumford
Bluesky runners: winter is coming. how do yall keep consistent with your miles? do you migrate to indoor tracks, just pray there's no ice, moderate your speed when it has snowed, switch to running on road, make peace with the treadmill?
September 26, 2025 at 11:06 PM
Bluesky runners: winter is coming. how do yall keep consistent with your miles? do you migrate to indoor tracks, just pray there's no ice, moderate your speed when it has snowed, switch to running on road, make peace with the treadmill?
Reposted by Tom Mumford
The debate around what is or isn’t “cancel culture” really just obscures a simple truth that it’s BAD to be massively racist/sexist/homophobic/transphobic and it’s GOOD to speak out against injustice. Some things are good and some things are bad and it’s okay to say which you think are which.
September 20, 2025 at 4:28 PM
The debate around what is or isn’t “cancel culture” really just obscures a simple truth that it’s BAD to be massively racist/sexist/homophobic/transphobic and it’s GOOD to speak out against injustice. Some things are good and some things are bad and it’s okay to say which you think are which.
NADDPOD @naddpod.bsky.social
thinking basketball @thinkingbasketball.bsky.social
unclear and present danger @unclearpod.bsky.social
decoder ring @willa.bsky.social
99% invisible @99pi.org
my girlfriend is really not a podcast person at all but she accepts me for who I am
thinking basketball @thinkingbasketball.bsky.social
unclear and present danger @unclearpod.bsky.social
decoder ring @willa.bsky.social
99% invisible @99pi.org
my girlfriend is really not a podcast person at all but she accepts me for who I am
dating apps should just make men list their top 5 podcasts
September 17, 2025 at 2:53 PM
NADDPOD @naddpod.bsky.social
thinking basketball @thinkingbasketball.bsky.social
unclear and present danger @unclearpod.bsky.social
decoder ring @willa.bsky.social
99% invisible @99pi.org
my girlfriend is really not a podcast person at all but she accepts me for who I am
thinking basketball @thinkingbasketball.bsky.social
unclear and present danger @unclearpod.bsky.social
decoder ring @willa.bsky.social
99% invisible @99pi.org
my girlfriend is really not a podcast person at all but she accepts me for who I am
it's a hobby horse of mine that consumer-facing tech, particularly apps, are pretty bad and getting worse over time- the spotify feature where it'll make you a playlist at a certain BPM doesn't actually work at all. rounding to the nearest 10 BPM, *ONE* of these is 180bpm. a bunch aren't even close
August 22, 2025 at 6:24 PM
it's a hobby horse of mine that consumer-facing tech, particularly apps, are pretty bad and getting worse over time- the spotify feature where it'll make you a playlist at a certain BPM doesn't actually work at all. rounding to the nearest 10 BPM, *ONE* of these is 180bpm. a bunch aren't even close
Reposted by Tom Mumford
give me a bag of these and you don't even have to worry about the money
August 21, 2025 at 1:03 AM
give me a bag of these and you don't even have to worry about the money
Reposted by Tom Mumford
We traveled to DC to talk to Congressional Staffers about the impact of NIH and NIBIB funding. It enables us to develop synthetic biology tools to advance cell & genetic medicines for patients in need. REPOST to deliver the message that SCIENCE saves lives & makes America GREAT!
July 21, 2025 at 12:16 PM
We traveled to DC to talk to Congressional Staffers about the impact of NIH and NIBIB funding. It enables us to develop synthetic biology tools to advance cell & genetic medicines for patients in need. REPOST to deliver the message that SCIENCE saves lives & makes America GREAT!
Reposted by Tom Mumford
babe wake up it’s time for another six hours of Sinner-Alcaraz
July 13, 2025 at 3:00 PM
babe wake up it’s time for another six hours of Sinner-Alcaraz
Reposted by Tom Mumford
Why carmakers need to bring back buttons - great column by June Yoon how makers shifted to touchscreen dominated dashboards. It was cheaper and helped monetise software. But they are now realise it is not so safe - ie finding a hazard light screen icon in an emergency www.ft.com/content/b463...
Why carmakers need to bring back buttons
Asian companies lead a reversal from touchscreen-dominated dashboards
www.ft.com
July 9, 2025 at 6:04 AM
Why carmakers need to bring back buttons - great column by June Yoon how makers shifted to touchscreen dominated dashboards. It was cheaper and helped monetise software. But they are now realise it is not so safe - ie finding a hazard light screen icon in an emergency www.ft.com/content/b463...
Reposted by Tom Mumford
I'm increasingly becoming a luddite about many things, but especially cars. It's actually insane that we've accepted a world where every new car sold has a big tablet in the driver's view. It's one of the most baffling things about the modern world, actually.
Why carmakers need to bring back buttons - great column by June Yoon how makers shifted to touchscreen dominated dashboards. It was cheaper and helped monetise software. But they are now realise it is not so safe - ie finding a hazard light screen icon in an emergency www.ft.com/content/b463...
Why carmakers need to bring back buttons
Asian companies lead a reversal from touchscreen-dominated dashboards
www.ft.com
July 9, 2025 at 6:23 AM
I'm increasingly becoming a luddite about many things, but especially cars. It's actually insane that we've accepted a world where every new car sold has a big tablet in the driver's view. It's one of the most baffling things about the modern world, actually.
Reposted by Tom Mumford
summer tomatoes justify putting up with 60% of summer's garbage
July 8, 2025 at 12:51 PM
summer tomatoes justify putting up with 60% of summer's garbage
Reposted by Tom Mumford
ok i screamed at this one
July 6, 2025 at 10:47 PM
ok i screamed at this one