Brill-Weil et al. show that axonal GABAA receptors regulate excitatory nicotinic input onto the axons of dopaminergic neurons. This regulation alters integration of the subthreshold nicotinic input to...

Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged healthy donors directly into neurons, which retained their aging hallmarks, and we verified key findings in aged human and mouse brain tissue. Here we show that aged neurons are broadly depleted of RNA-binding proteins, especially spliceosome components. Intriguingly, splicing proteins—like the dementia- and ALS-associated protein TDP-43—mislocalize to the cytoplasm in aged neurons, which leads to widespread alternative splicing. Cytoplasmic spliceosome components are typically recruited to stress granules, but aged neurons suffer from chronic cellular stress that prevents this sequestration. We link chronic stress to the malfunctioning ubiquitylation machinery, poor HSP90α chaperone activity and the fai

SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical...

Roughly a third of Baltimore residents don’t have a car in a city where getting around without one can be an exercise in planning ahead, or, at worst, a serious barrier to work and life.

In the 15 years since its founding, Volo Sports has grown to be the largest provider of social sports in the nation. And the company’s nonprofit arm, launched in 2015, has grown too.

By analysing the smartphone data of 2,112,288 participants, in particular observing and comparing the activity of the same individual in two different environments, we find that increases in the walka...

Bowdoin College’s Program of Neuroscience invites applications for a full-time tenure-track faculty appointment in Neuroscience at the Assistant Professor level, beginning July 1, 2026. We seek applic...

Williams College says NSF and NIH requirement related to discrimination “undermines” academic freedom

So far, the promised overhaul of Baltimore's permit backlog hasn't worked, according to city data.

The Johns Hopkins University will freeze staff hiring and pay increases as it deals with federal funding losses