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Reposted by Yap Research group

Ronja Houtekamer @ronjahoutekamer.bsky.social · 25d

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding

Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

tinyurl.com

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Yap Research group @yap-lab.bsky.social · Aug 22

Excellent work by @juliaeckert.bsky.social- now online!

Julia Eckert @juliaeckert.bsky.social · Aug 15

Now published in @natcomms.nature.com! 🥳

👉 rdcu.be/eATn3

We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

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Reposted by Yap Research group

epithelial mechanics fan club @epimechfc.bsky.social · Jun 8

What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?

I'm @juliaeckert.bsky.social. Let's explore some analysis software!‬

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Reposted by Yap Research group

Zoya Mann @zoya-mann.bsky.social · May 24

Got this fantastic opportunity to attend a special interest symposium at MIMS2025, and present a poster about my ongoing scRNAseq work. Brilliant talks and engaging discussions- thank you Australian and New Zealand Society for Immunology for hosting such an insightful event! #scrnaseq #immunology

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Yap Research group @yap-lab.bsky.social · May 25

How do epithelia adapt to mechanical stresses? What roles do junctional complexes AJs & desmosomes play in this mechanotransduction?

Check out our new review article by @juliaeckert.bsky.social & Virgile Viasnoff, discussing these ideas! 👇

Julia Eckert @juliaeckert.bsky.social · May 25

Our new review paper from @yap-lab.bsky.social is online - together with Virgile Viasnoff!

👉 'New directions in epithelial mechanoadaptation'

www.sciencedirect.com/science/arti...

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Yap Research group @yap-lab.bsky.social · May 8

Congratulations Caren - this is wonderful news and we are all delighted.

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Yap Research group @yap-lab.bsky.social · May 1

Congratulations @juliaeckert.bsky.social for this feat!

Julia Eckert @juliaeckert.bsky.social · May 1

Started my first day as a Walter Benjamin Fellow! 🥳

Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology!

Big thanks to the @dfg.de for funding my research.

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Reposted by Yap Research group

plotnikovlab.bsky.social @plotnikovlab.bsky.social · Mar 30

Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!

www.biorxiv.org/content/10.1...

A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...

www.biorxiv.org

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Reposted by Yap Research group

epithelial mechanics fan club @epimechfc.bsky.social · Mar 30

How is extrusion of infected host cells related to ERK (extracellular signal-regulated kinase) activity?

Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.

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Reposted by Yap Research group

Benoit Ladoux @bladoux.bsky.social · Mar 14

Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...

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Reposted by Yap Research group

Rashmi Priya @rashmi-priya.bsky.social · Mar 10

Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...

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Reposted by Yap Research group

epithelial mechanics fan club @epimechfc.bsky.social · Mar 9

This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.

I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.

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Reposted by Yap Research group

Journal of Cell Biology @jcb.org · Feb 26

ICYMI: Discover new insights on chromosome size sensing by kinetochores, mechanical resistance at tight junctions, force-exerting focal adhesions formed by T cells, and how nuclei serve as mechanical bumpers, in our new #Mechanobiology collection 👉 https://buff.ly/3EK0uaq

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Reposted by Yap Research group

CellMech2025 @cellmech2025.bsky.social · Feb 4

🚨 We are thrilled to announce our amazing list of keynote speakers!!

@PCusachs
@GeorgHalder
@hirashima0203.bsky.social
@iberd.bsky.social
@johannaivaska.bsky.social
@gijsjekoenderink.bsky.social
@laurentnguyen.com
@renkawitzteam.bsky.social
@Sixt_Lab
...

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Reposted by Yap Research group

Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · Feb 25

Epigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...

2025 Epigenetics Conference GRC

The 2025 Gordon Research Conference on Epigenetics will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

www.grc.org

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Yap Research group @yap-lab.bsky.social · Feb 22

Want to learn more about cell extrusion? What causes it and why is it essential? Check out this fantastic thread by our student @zoya-mann.bsky.social elaborating on the epithelial mechanics of cell extrusion!👇
Follow @epimechfc.bsky.social for more such cool threads..

epithelial mechanics fan club @epimechfc.bsky.social · Feb 22

How do epithelial monolayers respond to apoptotic cells? What happens to these cells within hypertensile epithelia?More importantly, what is hypertensile epithelia and what leads to it?

I am @zoya-mann.bsky.social and I will talk about epithelial mechanics of apoptotic cell extrusion.

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Reposted by Yap Research group

Sara Wickstrom @sarawickstrom.bsky.social · Feb 15

My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email

Cell and Tissue Dynamics (Wickström)

www.mpi-muenster.mpg.de

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Reposted by Yap Research group

Nicolas Minc @minclab.bsky.social · Jan 3

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!

@ijmonod.bsky.social @cnrs.bsky.social

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Reposted by Yap Research group

epithelial mechanics fan club @epimechfc.bsky.social · Feb 13

Roffay, C., Chan, C. J., Guirao, B., Hiiragi, T., & Graner, F. (2021). Inferring cell junction tension and pressure from cell geometry. Development (Cambridge, England), 148(18), dev192773. #EpithelialMechanicsReview

journals.biologists.com/dev/article/...

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Yap Research group @yap-lab.bsky.social · Feb 10

Check this out!👇
Our new work reveals anilin’s putative role in mediating actomyosin remodeling and membrane composition

Julia Eckert @juliaeckert.bsky.social · Feb 10

Congratulations to Denni from our @yap-lab.bsky.social team and all authors on the new paper! 🥳

'Advecting scaffolds: Controlling the remodeling of actomyosin with anillin' 👇

journals.aps.org/pre/abstract...

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Reposted by Yap Research group

FocalPlane @focalplane.bsky.social · Feb 7

Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap @yap-lab.bsky.social (Institute for Molecular Bioscience, IMB, University of Queensland).
focalplane.biologists.com/cell-biology...

Two post-doctoral positions to study the mechanisms of epithelial homeostasis - FocalPlane

Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap (Institute for Molecular Bioscience, IMB, University of Queensland)...

focalplane.biologists.com

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Reposted by Yap Research group

Yap Research group @yap-lab.bsky.social · Feb 3

🚨Postdoc vacancy alert!

Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?

2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...

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Yap Research group @yap-lab.bsky.social · Feb 3

Looking for a tool to analyse cell / tissue orientation on surfaces of 3D systems?

Check out this extremely user friendly tool generated by @juliaeckert.bsky.social in her new preprint👇

Julia Eckert @juliaeckert.bsky.social · Jan 29

Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!

www.biorxiv.org/content/10.1...

Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris

Any 3D systems?👇

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Yap Research group @yap-lab.bsky.social · Feb 3

🚨Postdoc vacancy alert!

Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?

2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...

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Reposted by Yap Research group

Julia Eckert @juliaeckert.bsky.social · Jan 29

Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!

www.biorxiv.org/content/10.1...

Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris

Any 3D systems?👇

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