“Fibromyalgia #LegPain is also crippling in many ways. You can’t imagine how many types of #pain I experience with #fibromyalgia. From #paresthesia to #allodynia, fibromyalgia continues to find new ways to torture me day in and day out.”: buff.ly/8iv33ww
by @carriekellenberger.bsky.social
#NEisVoid
by @carriekellenberger.bsky.social
#NEisVoid
February 6, 2026 at 8:30 PM
“Fibromyalgia #LegPain is also crippling in many ways. You can’t imagine how many types of #pain I experience with #fibromyalgia. From #paresthesia to #allodynia, fibromyalgia continues to find new ways to torture me day in and day out.”: buff.ly/8iv33ww
by @carriekellenberger.bsky.social
#NEisVoid
by @carriekellenberger.bsky.social
#NEisVoid
Open Access UCL Research: Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β-related pathway in macrophages discovery.ucl.ac.uk/id/eprint/10...
Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β-related pathway in macrophages
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UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
February 6, 2026 at 12:22 PM
Open Access UCL Research: Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β-related pathway in macrophages discovery.ucl.ac.uk/id/eprint/10...
กุนั่งหาคำว่า allodynia ในโน้ตอยุชั่วโมงนึง เจอตั้งแต่จดหมายบอกเลิกจากแฟนเก่ายันพล็อตนิยาย 555
February 6, 2026 at 12:23 PM
กุนั่งหาคำว่า allodynia ในโน้ตอยุชั่วโมงนึง เจอตั้งแต่จดหมายบอกเลิกจากแฟนเก่ายันพล็อตนิยาย 555
treatments. Macrophages respond to CGRP, contribute to cortical spreading depolarization and orofacial mechanical allodynia, and may be modulated to enhance an anti-inflammatory environment. (🧵 5/8)
February 6, 2026 at 5:41 AM
treatments. Macrophages respond to CGRP, contribute to cortical spreading depolarization and orofacial mechanical allodynia, and may be modulated to enhance an anti-inflammatory environment. (🧵 5/8)
targets for current and future therapies. As reviewed in this manuscript, preclinical evidence links astrocytes, microglia and satellite glial cells with cortical spreading depolarization, trigeminovascular activation, and the development of orofacial allodynia, processes that (🧵 3/8)
February 6, 2026 at 5:41 AM
targets for current and future therapies. As reviewed in this manuscript, preclinical evidence links astrocytes, microglia and satellite glial cells with cortical spreading depolarization, trigeminovascular activation, and the development of orofacial allodynia, processes that (🧵 3/8)
Destroy allodynia as a concept 2k26
February 6, 2026 at 12:53 AM
Destroy allodynia as a concept 2k26
“with #allodynia translating even the most innocuous sound and stimuli to pain, it’s hard to think of anything at all beyond the moment, beyond that pain.": buff.ly/Y4UsZMH
by @apainprincess.bsky.social
#PainFlare #ChronicPain #CRPS #ChronicIllness #InvisibleIllness
by @apainprincess.bsky.social
#PainFlare #ChronicPain #CRPS #ChronicIllness #InvisibleIllness
How to Cope with Flare-Ups & Setbacks of Chronic Pain—with Tools to
Finding ways to live with severe pain and complex chronic illness — when so much is altered by their constant presence — is a process we must learn again and again, especially with flare-ups and set
buff.ly
February 5, 2026 at 8:30 PM
“with #allodynia translating even the most innocuous sound and stimuli to pain, it’s hard to think of anything at all beyond the moment, beyond that pain.": buff.ly/Y4UsZMH
by @apainprincess.bsky.social
#PainFlare #ChronicPain #CRPS #ChronicIllness #InvisibleIllness
by @apainprincess.bsky.social
#PainFlare #ChronicPain #CRPS #ChronicIllness #InvisibleIllness
Me: Hmmmm. Got some allodynia today. I wonder if...
Me: *squeezes the hurting skin*
Me:
Me: *dies*
Fact: you can't stimulate the pain away with allodynia like you can do with muscle soreness.
Me: *squeezes the hurting skin*
Me:
Me: *dies*
Fact: you can't stimulate the pain away with allodynia like you can do with muscle soreness.
February 4, 2026 at 5:58 PM
Me: Hmmmm. Got some allodynia today. I wonder if...
Me: *squeezes the hurting skin*
Me:
Me: *dies*
Fact: you can't stimulate the pain away with allodynia like you can do with muscle soreness.
Me: *squeezes the hurting skin*
Me:
Me: *dies*
Fact: you can't stimulate the pain away with allodynia like you can do with muscle soreness.
A GLP1 side effect that I never paid much attention to was Allodynia and I didn’t pay attention to it because after almost 2 years I had never experienced it… Until now! This is no joke! Has anyone else experienced this and if so, what do you do to soothe it?
February 3, 2026 at 6:16 PM
A GLP1 side effect that I never paid much attention to was Allodynia and I didn’t pay attention to it because after almost 2 years I had never experienced it… Until now! This is no joke! Has anyone else experienced this and if so, what do you do to soothe it?
transcriptomic, biochemical, and functional approaches.
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
February 3, 2026 at 12:51 PM
transcriptomic, biochemical, and functional approaches.
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
Does anyone else have allodynia? I get it all over my body during a flare up and it's so bad in my one hand today. For those who don't know, allodynia is a nerve issue that causes areas of your skin to be extremely painful to touch or temperature changes. 😓 Mines both a lot of the time.
February 2, 2026 at 4:18 PM
Does anyone else have allodynia? I get it all over my body during a flare up and it's so bad in my one hand today. For those who don't know, allodynia is a nerve issue that causes areas of your skin to be extremely painful to touch or temperature changes. 😓 Mines both a lot of the time.
I have allodynia, and anyway I lost my bp machine 🙁
February 2, 2026 at 7:39 AM
I have allodynia, and anyway I lost my bp machine 🙁
I never heard of it before but he inferred that it is used for diabetic neuropathy and may help as the allodynia is right where my bra touches my back and shoulders. Botox only helps for 8-10 weeks.
February 2, 2026 at 2:42 AM
I never heard of it before but he inferred that it is used for diabetic neuropathy and may help as the allodynia is right where my bra touches my back and shoulders. Botox only helps for 8-10 weeks.
I've never used ketamine typically but have had intranasal. I was prescribed a super low dose, though, so found it ineffective. I don't know much about topical k.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
February 2, 2026 at 2:21 AM
I've never used ketamine typically but have had intranasal. I was prescribed a super low dose, though, so found it ineffective. I don't know much about topical k.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
I haven’t tried any. I have had allodynia so bad the days I don’t have migraine pain that I need to do something. Anything that helps break the cycle because I’m so light sensitive driving is an issue. My pharmacist offered ketamine cream and said to ask the people who really know.
February 2, 2026 at 2:14 AM
I haven’t tried any. I have had allodynia so bad the days I don’t have migraine pain that I need to do something. Anything that helps break the cycle because I’m so light sensitive driving is an issue. My pharmacist offered ketamine cream and said to ask the people who really know.
Allodynia is one of the worst fibro symptoms and so hard to explain to people. Ice is smart for that. I started logging what triggers those flares using the CareClinic app and found a pattern with weather and stress. Might help you spot yours too. Hope the ice gives you some relief tonight.
January 28, 2026 at 8:14 PM
Allodynia is one of the worst fibro symptoms and so hard to explain to people. Ice is smart for that. I started logging what triggers those flares using the CareClinic app and found a pattern with weather and stress. Might help you spot yours too. Hope the ice gives you some relief tonight.
#ChronicPain #CRPS #Allodynia #Arthritis #SpinalStenosis #BrokeBackL1 #Lupus #Sjogrens #Dystonia #COPD #DEPRESSION ...and #RELEASE the #EpsteinFiles
January 27, 2026 at 7:32 PM
I am ABSOLUTELY RAGING, pals. When I had my stroke the medical team knew a) I had fibro b) I’m hypermobile.
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
January 26, 2026 at 9:40 AM
I am ABSOLUTELY RAGING, pals. When I had my stroke the medical team knew a) I had fibro b) I’m hypermobile.
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
My foot recently joined the pain party and started hurting to put weight on my heel.
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
January 24, 2026 at 10:15 PM
My foot recently joined the pain party and started hurting to put weight on my heel.
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
Managing #Autoimmune condition has been an increased challenge the last few weeks with added stress of what is happening in #Minneapolis. Its like a game of whack-a-mole with symptom flares from hypnotic jerks to allodynia & paresthesia to severe bursitis & more. Just trying to get through.
January 23, 2026 at 5:13 PM
Managing #Autoimmune condition has been an increased challenge the last few weeks with added stress of what is happening in #Minneapolis. Its like a game of whack-a-mole with symptom flares from hypnotic jerks to allodynia & paresthesia to severe bursitis & more. Just trying to get through.
Allodynia is pain with light touch. Something I assumed was normal my entire life until recently 🧍
January 23, 2026 at 7:02 AM
Allodynia is pain with light touch. Something I assumed was normal my entire life until recently 🧍
I told my rheumatologist about one of my symptoms and she goes “ oh, that’s allodynia” and I’m like “ actually I did know the name because i googled it once 👉👈”
She said it was good I had done research. Most doctors hate that.
She said it was good I had done research. Most doctors hate that.
January 23, 2026 at 7:02 AM
I told my rheumatologist about one of my symptoms and she goes “ oh, that’s allodynia” and I’m like “ actually I did know the name because i googled it once 👉👈”
She said it was good I had done research. Most doctors hate that.
She said it was good I had done research. Most doctors hate that.
Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour …
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour in male and female rats
No abstract...
pubmed.ncbi.nlm.nih.gov
January 23, 2026 at 5:51 AM
Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour …
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia
Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia
Peripheral mechanisms of mechanical allodynia after nerve injury remain unclear. Li et al. identify a subset of trigeminal afferents in mice activated by facial brushing after nerve injury. Targeted manipulations reveal these neurons’ causal role in pain-like behaviors and heightened sensitivity, providing new insights into primary afferents underlying mechanical allodynia.
dlvr.it
January 21, 2026 at 8:51 PM
Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia
Oh, that makes sense. I'd say I haven't had a migraine this week, but maybe one's coming? I have a lot of nerve problems, and this could be anything from aura to allodynia due to fibro/small fiber neuropathy.
It's happened before, but I never thought to track it. I should do that.
It's happened before, but I never thought to track it. I should do that.
January 21, 2026 at 5:44 PM
Oh, that makes sense. I'd say I haven't had a migraine this week, but maybe one's coming? I have a lot of nerve problems, and this could be anything from aura to allodynia due to fibro/small fiber neuropathy.
It's happened before, but I never thought to track it. I should do that.
It's happened before, but I never thought to track it. I should do that.