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spo11rulz.bsky.social
Scott Keeney
@spo11rulz.bsky.social
860 followers 380 following 20 posts

HHMI Investigator and Member, Molecular Biology Program, Memorial Sloan Kettering Cancer Center. Scientist. Meiosis nerd. 🏳️‍🌈 Queer as a $3 bill. He/him. Spo11 Rules!

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Scott Neal Keeney is an American molecular biologist.

Source: Wikipedia
Biology 85%
Medicine 10%
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Aug 16
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
Insight into Meiotic DNA End Resection: Mechanisms and Regulation
Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…
www.sciencedirect.com
13 23

spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · May 6
Please repost: I'm looking for suggestions for activities (scientific, social, team-building, whatever) for a lab retreat. What worked well in retreats you've been to?

(I put this on Twitter a while ago and got some great responses, but lost the info when I deleted that account.)

Reposted by Scott Keeney

mollyprz.bsky.social
Molly Przeworski @mollyprz.bsky.social · Apr 29
Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Apr 21
Proud of PhD student Zack Zheng for his successful thesis defense today. Here's the cake to prove it...
1 26

Reposted by Scott Keeney

peiferlabunc.bsky.social
Mark Peifer (He, him) @peiferlabunc.bsky.social · Mar 31
>1900 members of the National Academies of Science, Engineering & Medicine issued a statement supporting science for the benefit of all citizens, and ... 1/2
docs.google.com/document/d/1...
Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
docs.google.com
3 61 110

spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Mar 5
Pro tip: if you have a really important zoom interview, double check that you are not in the same room as a cat that is likely to start crying to be let out #HypotheticallySpeaking
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Reposted by Scott Keeney

mskcancercenter.bsky.social
Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · Mar 4
MSK has been recognized as one of the national's top workplaces for inclusion and diversity by @newsweek.com magazine. 🎉

MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...
America's Greatest Workplaces for Inclusion & Diversity 2025
Newsweek is partnering with Plant-A Insights Group to honor America's Greatest Workplaces for Inclusion & Diversity 2025. These companies are committed to fostering an inclusive and diverse work envir...
www.newsweek.com
9 20

Reposted by Scott Keeney

labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Feb 19
Cell-free system enables detailed study of the role of SPO11 in meiosis
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@ccb-lab.bsky.social @spo11rulz.bsky.social
Key process in sex-cell formation can finally be studied in vitro
Activity of the purified SPO11 enzyme reconstituted in cell-free system.
www.nature.com
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Reposted by Scott Keeney

needhibhalla.bsky.social
Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · Feb 19
the version of record (VoR) of our most recent paper has been published @elife.bsky.social! 🎉🥳 🧪

elifesciences.org/articles/102...
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Reposted by Scott Keeney

hitenmadhani.bsky.social
Hiten Madhani @hitenmadhani.bsky.social · Feb 18
Our latest preprint describes methods and tools that enable >99% efficient short homology-dependent genome editing in the human fungal pathogen Cryptococcus neoformans. Congratulations to Matt, Sanjita, and Manning!

www.biorxiv.org/content/10.1...
Near 100% efficient homology-dependent genome engineering in the human fungal pathogen Cryptococcus neoformans
We recently described CRISPR/Cas9-based short homology-dependent genome engineering in the human fungal pathogen Cryptococcus neoformans , a haploid budding yeast that is the most common cause of fung...
www.biorxiv.org
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Feb 2
Probably not all that stout... looks like it's just puffed up to stay warm
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Feb 1
Looking forward to having you as a neighbor!
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Feb 1
And I'm waiting for someone to correct my saying Vanya instead of Nenya 🫢

Or was that the Chekhov/Tolkien mashup we didn't know we needed?
1 1

spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Feb 1
"I have a comment and a question. The comment is just to clarify: of course, as everyone knows, that inscription is not in Elvish, it's the Black Speech of Mordor." Scott never forgave me.
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Feb 1
2) At the start of an absolutely fabulous talk about three new RING genes his group had discovered and named Narya, Vilya, and Vanya after the three Elven rings in LOTR, Scott showed the inscription from the One Ring and described it as being in Elvish. After the talk, I raised my hand...
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Feb 1
Two Scott stories that stick in my head, both from talks at Meiosis Gordon conferences. 1) After mentioning something about Gregor Mendel's son, a pause, then "Mendel was a great geneticist but terrible monk"
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Jan 31
Oh no! This is very sad news.
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Reposted by Scott Keeney

lacefieldlab.bsky.social
Soni Lacefield @lacefieldlab.bsky.social · Jan 31
Feeling very lost today with the news of the passing of my undergrad advisor Scott Hawley. He had a huge impact on the field and on me personally. He was the first person to see me as a scientist and gave me the confidence to apply to grad school. I am so grateful to be a part of his legacy.
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Reposted by Scott Keeney

hunterlab.bsky.social
HunterLab.bsky.social @hunterlab.bsky.social · Jan 31
Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.
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Reposted by Scott Keeney

naamaaviram.bsky.social
Naama Aviram @naamaaviram.bsky.social · Jan 2
New year, new beginnings! 🎉

The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!

We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.

#NewPI #AcademicSky #WomenInSTEM
(1/2)
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Dec 23
Spatchcock for the win!
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Dec 17
Hmmmm, that's surprising that the Galangal syrup ended up tasting cheesy. Couldn't have been the added rutabaga, so...? 🤔
1

Reposted by Scott Keeney

clauswilke.com
Claus Wilke @clauswilke.com · Dec 17
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
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Reposted by Scott Keeney

labneale.bsky.social
NealeLab @labneale.bsky.social · Dec 5
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...
Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications
Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...
www.nature.com
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Reposted by Scott Keeney

artermeret.bsky.social
Meret Arter @artermeret.bsky.social · Nov 27
Shoutout to the unknown artist and their work in the mskcc elevator this morning 😂
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Reposted by Scott Keeney

choijunhong.bsky.social
Junhong Choi @choijunhong.bsky.social · Nov 25
Pretty excited to see our review & DNA Typewriter covered by NY Times! Perhaps too much excitement for one Monday 🥲 www.nytimes.com/2024/11/25/s...
‘DNA Typewriters’ Can Record a Cell’s History
Labs around the world are trying to turn cells into autobiographers, tracking their own development from embryos to adults.
www.nytimes.com
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Reposted by Scott Keeney

semirkin.bsky.social
semirkin.bsky.social @semirkin.bsky.social · Nov 25
Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab.

www.pnas.org/doi/10.1073/pnas.2413298121
Recurrent DNA nicks drive massive expansions of (GAA)n repeats | PNAS
Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA)n repeat expansions are responsible for...
www.pnas.org
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Nov 24
The editor changed most (but strangely not all) instances of "mutant1 mutant2" (meaning the double mutant genotype) to "mutant1 or mutant2", which changed the meaning to either gibberish or something completely wrong, depending on context. This was tricky to catch in the proofs

spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Nov 24
To journal editorial folks: If your journal doesn't already, please consider changing your work flow to return to authors at the proof stage a copy-edited version of their paper with editors' changes tracked. Just caught a major editor's mistake in some proofs.
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spo11rulz.bsky.social
Scott Keeney @spo11rulz.bsky.social · Nov 23
It took us another 25+ years to figure out how to do it, and thankfully MSK didn't fire me in the interim 🫠
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