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William Wade

William Wade

@oralmolecol.bsky.social

28 followers 53 following 4 posts

Professor of Oral Microbiology, King’s College London. Microbiome.

Medicine 49%

Public Health 27%

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Posts Replies Media Videos

Dave Vetter @davidrvetter.bsky.social · 1d

Still reeling from the Stanford report on Brexit. Reduced GDP by up to 8% and investment by as much as 18%. The UK Treasury would have £40 billion more each year if Britain had remained in the EU. Devastating self-immolation.

The Economic Impact of Brexit

siepr.stanford.edu

Reposted by Jesse M. Shapiro, Alan McNally, William G. Wade

Louis-Marie Bobay @lbobay.bsky.social · 7d

Our latest paper is out with @adiop.bsky.social and @gmdouglas.bsky.social. We analyzed the extent of homologous recombination between bacterial species (introgression) and how it affects species borders (it can vary a lot depending on the approach used to classify species!). rdcu.be/eQAMf

Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy

Nature Communications - It is commonly thought that bacterial species borders tend to be fuzzy, due to frequent exchange of DNA. Here, Diop et al. quantify the patterns of gene flow between core...

Reposted by William G. Wade

Emmanuele Severi @emmseveri.bsky.social · 26d

#microsky oral #microbiome goes supersize

www.sciencedirect.com/science/arti...

A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights

The oral microbiome is increasingly linked to human health. To further examine this microbial community, we present the human reference oral microbiom…

www.sciencedirect.com

Reposted by William G. Wade

Emmanuele Severi @emmseveri.bsky.social · Sep 22

www.biorxiv.org/content/10.1...

#microsky but feels more like Horrible Histories!

The oral microbiome of King Richard III of England

Metagenomic investigation of archaeological dental calculus has provided insights into the changing oral health, disease, and diet of past human societies, but little is known about the oral microbiot...

www.biorxiv.org

Reposted by William G. Wade

Emmanuele Severi @emmseveri.bsky.social · Sep 5

www.jbc.org/article/S002...

#microsky #sialic acid

Interesting story, the starting Q v. important

Sialic acid identity modulates host tropism of sialoglycan-binding viridans group streptococci

Microbial interactions with multiple species may expand the range of potential hosts, supporting both pathogen reservoirs and zoonotic spillover. Viridans group streptococci interact with host cells b...

Reposted by William G. Wade

Emmanuele Severi @emmseveri.bsky.social · Aug 22

www.nature.com/articles/s41...

#microsky

Discovery of a widespread chemical signalling pathway in the Bacteroidota - Nature

The N-acyl-cyclolysine system regulates the expression of co-localized operons encoding diverse secreted molecules in Bacteroidota.

William Wade @oralmolecol.bsky.social · Jun 17

Don’t think much of the standard of English at that school if they say “heart-wrenching”. It’s “heart-rending” or “gut-wrenching”!

Reposted by Mart Krupovìč, William G. Wade

DEEMteam_Orsay @deemteam.bsky.social · Jun 17

📣 We are proud of the publication of the second paper of @bbaker24.bsky.social PhD thesis. In collaboration with friends in Halifax we have studied the difficult question of the phylogeny of the DPANN archaea, composed of several phyla of highly reduced, fast-evolving epiparasites 🧵

rdcu.be/erkkU

Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors

Nature Microbiology - Phylogenetic reconstructions with conserved protein markers from the 11 known DPANN phyla reveal their monophyletic placement within the Euryarchaeota.

Reposted by Marc Strous, Andrew L. Jackson, William G. Wade

Glen Dsouza @nonresidentdesi.bsky.social · Jun 13

Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours.

www.science.org/doi/10.1126/...

#MicroSKy #Microbiology

Antagonism as a foraging strategy in microbial communities

In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...

www.science.org

Reposted by Mya Breitbart, William G. Wade

Christine Moissl-Eichinger @chmoei.bsky.social · Jun 3

📢 Big day for archaeal microbiology!

Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com ‬ in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.

Reposted by William G. Wade

Bat Bor @batbilegbor.bsky.social · Jun 3

Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1...

Reposted by John De Vos, Jacalyn Duffin, Derrick L. Cogburn , and 1 more John De Vos, Jacalyn Duffin, Derrick L. Cogburn, William G. Wade

Seth Abramson @sethabramson.bsky.social · Mar 10

In a world of Matts, be a Derek.

Reposted by Cary L. Cooper, Derrick L. Cogburn, William G. Wade , and 2 more Cary L. Cooper, Derrick L. Cogburn, William G. Wade, C. H. Cheng, Patricia Baker

Richard Branson @richardbranson.bsky.social · Feb 20

President Zelenskyy has been one of the greatest leaders of our time, guiding Ukraine through the darkest period of its recent history, rising up to Russia’s unwarranted aggression, being an inspiration to the Ukrainian people and ensuring that Ukraine’s voice is heard on the world stage.

William Wade @oralmolecol.bsky.social · Feb 19

Currant bun

Reposted by William G. Wade, Alan W. Walker

Nature Microbiology @natmicrobiol.nature.com · Feb 4

EDITORIAL: Ensuring rigour of low-biomass microbiome research

Read it here: www.nature.com/articles/s41...

#microsky #microbiomesky 🧪

Ensuring rigour of low-biomass microbiome research - Nature Microbiology

Determining whether human organs house a resident microbiome is challenging and the findings can be controversial. However, forging collaborations and careful study design can help overcome these issu...

Reposted by William G. Wade

thetranscendedman @atranscendedman.bsky.social · Dec 30

London study finds L. crispatus in the vaginal microbiome reduces inflammation by blocking harmful signals and activating anti-inflammatory pathways.

May protect against infections and preterm birth.

www.nature.com/articles/s41...

Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract - Nature Communications

Here, the authors show that vaginal lactobacilli associated with optimal health interact selectively with a restricted subset of anti-inflammatory receptors through their Surface Layer Proteins, both ...

Reposted by William G. Wade

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Dec 21

The Porphyromonas gingivalis lipid A 1-phosphatase LpxE has unique features and requires a functional type IX secretion system for its activity https://www.biorxiv.org/content/10.1101/2024.12.20.629629v1

Reposted by William G. Wade

Michael Wagner @michiwagner4.bsky.social · Dec 20

🌟 Exciting news! Our latest collaborative research with team @aarhusuni.bsky.social introduces pH-FISH, a novel technique combining pH ratiometry and FISH to simultaneously unravel microbial identity and local biofilm pH. 🔬 🧪 #MicroSky

link.springer.com/article/10.1...

#Microbiome #Biofilms

pH-FISH: coupled microscale analysis of microbial identity and acid–base metabolism in complex biofilm samples - Microbiome

Background Correlative structural and chemical imaging of biofilms allows for the combined analysis of microbial identity and metabolism at the microscale. Here, we developed pH-FISH, a method that co...

link.springer.com

Reposted by William G. Wade

Jonathan Eisen @phylogenomics.bsky.social · Dec 20

An important read for all microbiome researchers #microbiomania www.theguardian.com/science/2024...

There’s little evidence of a ‘brain microbiome’ | Letter

Letters: Prof Mark Pallen, Dr Aimee Parker, Prof Nick Loman and Prof Alan Walker take issue with an article that discussed the existence of a brain microbiome and its impact on diseases

www.theguardian.com

Reposted by Kevin Denny, Miguel Á. Malo, Jens Rommel , and 5 more Kevin Denny, Miguel Á. Malo, Jens Rommel, Julia Ramírez, Frédéric Delsuc, William G. Wade, Joshua P. Twining, Hansraj Gautam

Tanja Pyhäjärvi @pyhatanja.bsky.social · Dec 16

Big news from Finnish publication forum. Almost all MDPI and Frontiers journals will be downgraded to level 0 and thus are not considered as properly peer reviewed trustworthy scientific journals.
julkaisufoorumi.fi/en/news/chan...

Changes to the classification

julkaisufoorumi.fi

William Wade @oralmolecol.bsky.social · Dec 11

One of my favourite nerdy facts!

Reposted by William G. Wade

Bat Bor @batbilegbor.bsky.social · Dec 4

Excited to share our new preprint on the detailed investigation of Type 4 pili in epibiont oral Saccharibacteria! Led by Alex Grossman from our lab, and with Jun Liu (Yale), Jeff McLean (UW) and Xuesong He. Check it out: biorxiv.org/content/10.1...

Reposted by Victor A. Albert, William G. Wade

Zandra Fagernäs @zandraselina.bsky.social · Nov 25

The final chapter of my PhD thesis is finally out! Led by the brilliant Irina Velsko, we investigated if we can study past migrations in Oceania using #aDNA from archaeological dental calculus: www.nature.com/articles/s41...

Exploring the potential of dental calculus to shed light on past human migrations in Oceania - Nature Communications

Preservation of oral microbiome ancient DNA from Oceania is much better than human ancient DNA. The authors leverage this to demonstrate that oral microbial community composition in Oceania is not onl...

Reposted by William G. Wade

Katrina Ray @heykatray.bsky.social · Nov 15

This Perspective was a fun one to work on recently, examining the characteristics & role of small intestinal #microbiota, somewhat overlooked (tech difficulties in sampling, low microbial biomass) but important to health

www.nature.com/articles/s41...
🔓 rdcu.be/d0hBg

#GastroSky #Microsky

The figure shows the biogeographic characteristics of the gastrointestinal tract in humans and mice. There are distinct differences in multiple factors (length, pH) between human and mouse intestine. The small intestine exhibits distinct biogeographical characteristics, including length, pH, transit times, plicae circulares, mucus thickness, surface area ratio and microbiota profiles, compared with the large intestine.

Reposted by William G. Wade

Nick Loman @pathogenomenick.bsky.social · Aug 29

Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective academic.oup.com/jid/advance-... paging @faecalmatters.bsky.social

Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective

Low-biomass microbiome studies show great potential alongside major controversies. This review surveys key methodological challenges and discusses experime

academic.oup.com

Reposted by William G. Wade

Alex Crits-Christoph @acritschristoph.bsky.social · Aug 12

Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes (June 2024)

www.nature.com/articles/s41...

Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes - Nature Microbiology

Simultaneous DNA-FISH and multiplexed rRNA-FISH spatially map antimicrobial resistance plasmids and phage with their host taxa in polyspecies human oral biofilm samples, revealing hotspots of genetic ...

William Wade @oralmolecol.bsky.social · Jul 27

onlinelibrary.wiley.com/doi/10.1002/...

Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis

Click on the article title to read more.

onlinelibrary.wiley.com

Reposted by William G. Wade

Willem van Schaik @wvschaik.bsky.social · Jul 20

Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut

www.nature.com/articles/s41...

Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut - Nature Communications

Nature Communications - Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut

Reposted by William G. Wade

Onisillos @onisillos.bsky.social · Apr 11

Something to keep in your quote armory:

"...many papers in the literature report microbial associations that go against basic understanding of microbial ecology, some of which can be likened to reporting blue whales in the Himalayas or African elephants in Antarctica."

Recognizing the reagent microbiome - Nature Microbiology

A noticeable part of the microbiome literature, especially that working with low-biomass samples, is plagued by reagent contamination. Here we describe visual, statistical, methodical and ecological techniques to facilitate recognition of signals that represent contamination.

Reposted by William G. Wade

Willem van Schaik @wvschaik.bsky.social · Feb 12

Job claxon!

Colleagues at the School of Dentistry of the University of Birmingham are advertising for an Assistant/Associate Prof post in oral microbiology:

www.jobs.ac.uk/job/DFL084/a...
www.jobs.ac.uk/job/DFL092/a...

Assistant Professor in Microbiology at University of Birmingham

Discover an exciting academic career path as a Assistant Professor in Microbiology at jobs.ac.uk. Don't miss out on this job opportunity - apply today!