Gottardi Lab
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carajgottardi.bsky.social
Gottardi Lab
@carajgottardi.bsky.social
We study the multiple functions of catenins in cell-cell adhesion, cytoskeleton/nuclear signaling and lung repair after injury.
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To my fellow old farts: amplify junior PIs debuts. All of ‘em 🙌🏻👏🏻 all the best Maik, go get it.
So excited to share this as a new junior PI:

My brand-new lab website! 🎉🪰🌀
www.bischofflab.com

Please pass it on to young, motivated researchers looking for PhD positions 😊

And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!

#CellBio #DevBio #PhDjob #PhDposition #Science
November 27, 2025 at 8:37 AM
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Congrats to one of the most talented folks with whom I have ever worked. Follow Maik as he pursues new insights into morphogenesis using highly innovative multi-disciplinary tools! 🧪
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰

We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.

I’ll soon hire my first #PhD student — feel free to reach out!

#juniorPI #Science #devbio
November 26, 2025 at 1:00 PM
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So, let me share the NIGMS processes from my time.

1/8
I will share how things worked when I was at NIGMS back in the day.

I am confident in varies across institutes (as almost everything does).
November 25, 2025 at 3:58 PM
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New septin paper by our next door lab neighbors @ebrahim-lab.bsky.social, and on the cover of JCI Insight no less.

Septin 9 reinforces intestinal epithelial junctions, preventing leaky gut and inflammation.

Check it out!
This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social& team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...
November 24, 2025 at 7:45 PM
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Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
November 24, 2025 at 6:57 PM
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It was a great pleasure attending my first #HUPO world congress in Toronto last week and sharing our catenin phospho-code story! It was inspiring meeting with peers and pioneers in the field, which reminded me how special the proteomics community is!
November 21, 2025 at 8:13 PM
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A new enzyme-free technique uses alternating electrochemical currents to gently detach cells from culture surfaces, maintaining high cell viability and reducing waste in biomanufacturing processes. doi.org/hbbs27
Enzyme-free approach gently detaches cells from culture surfaces
Anchorage-dependent cells are cells that require physical attachment to a solid surface, such as a culture dish, to survive, grow, and reproduce.
phys.org
November 18, 2025 at 10:19 PM
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Thank you UVa for being the first places asking for grad school recomendations that did not include ANY of the silly ratings questions
November 4, 2025 at 10:53 PM
Bluesky folks, @jfhorner.bsky.social is also ON THE JOB MARKET! Check out his work 🧐... he's SUPER TALENTED and a pleasure to work with!
October 31, 2025 at 9:49 PM
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Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
October 6, 2025 at 6:09 PM
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that time of the year... writing letters for 8 UG's applying to grad school, each of them to ~15 programs. And while I passionately support every one of them, thats A LOT of letters, a lot of web sites to keep track of, a lot of my time. Why dont Grad programs use interfolio? One and done???
October 4, 2025 at 11:41 AM
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After a "suspension" of just a few days, UNC Professor Dwayne Dixon is re-instated, revealing the weakness of the fabricated issues used for the suspension. Here is his response. Stand up to the fascists--when we work together we can triumph.
October 4, 2025 at 1:18 PM
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My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls

Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨

🔗 www.nikonsmallworld.com/galleries/20...

#NikonSmallWorld #Microscopy #ScienceArt
October 3, 2025 at 9:06 AM
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Kate's work is remarkable--saw it at the Cell Contact and Adhesion GRC. Hiring faculty--she's a scientist to watch
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 11:28 PM
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A new email to Director Bhattacharya this morning.

1/n
September 28, 2025 at 12:05 PM
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"Head down focus on the science" folks: here is one super easy thing you can do today.
Here's my comment--join me. This would effectively remove foreign PhD students and postdocs from our labs. please share
September 27, 2025 at 2:53 PM
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An email to Director Bhattacharya to start the day

1/6
September 27, 2025 at 1:07 PM
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Super cool work from our institute!
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology
How epithelial junctions mature: Study shows conformational transition in key protein
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...
www.uni-muenster.de
September 10, 2025 at 8:10 AM
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Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...
Geometry first: how positional cues dictate fate in bilayered epithelia - the Node
Behind the paper story focussed on research on early fate decisions in bilayered epithelia.
thenode.biologists.com
September 9, 2025 at 7:12 AM
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Top-Down Individual Ion Mass Spectrometry Reveals 85-110 kDa Catenin Phospho-Proteoforms Regulated by Actomyosin Contractility https://www.biorxiv.org/content/10.1101/2025.09.06.674621v1
September 8, 2025 at 2:46 AM
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I'm more than a little excited about this interstellar visitor 🧪
The images keep getting better and the insights deeper
PS this is just some of the science funded by the NSF that is threatened by devastating budget cuts--speak up and call Congress.
www.sci.news/astronomy/in...
Interstellar Comet 3I/ATLAS Displays Broad Coma and Growing Tail | Sci.News
Using the Gemini Multi-Object Spectrograph (GMOS) on the Gemini South telescope at NSF’s International Gemini Observatory in the Chilean Andes, astronomers have captured new multi-color images of the ...
www.sci.news
September 6, 2025 at 6:41 PM
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We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12)

www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterned invagination prevents mechanical instability during gastrulation - Nature
In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphog...
www.nature.com
September 4, 2025 at 8:22 AM
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α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin https://www.biorxiv.org/content/10.1101/2025.08.21.671625v1
August 22, 2025 at 11:30 PM
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Indirect cost fun facts (from FY2024)

3 of the top 5 institutions in terms of negotiated indirect rates are pediatric hospitals.

The University of Kansas Medical Center had a higher negotiated indirect rate that Stanford.
August 7, 2025 at 11:38 PM