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Reposted by Dan Liebler

Nikolai Slavov @slavov-n.bsky.social · 1h

The antibodies don’t work! The race to rid labs of molecules that ruin experiments

Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.

www.nature.com/articles/d41...

The antibodies don’t work! The race to rid labs of molecules that ruin experiments

Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.

www.nature.com

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Reposted by Dan Liebler

Bill Grueskin @bgrueskin.bsky.social · 5d

Let's see how that government ban on White House demolition photos is going.

www.pbs.org/newshour/pol...

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Dan Liebler @dliebler.bsky.social · 5d

Vanderbilt response to the Trump ‘compact’ is too clever by half. Dodging the immoral dominance play and pretending it’s a reasoned conversation. Vandy wishes to play ball as an elite institution on a level with MIT, Penn and UVA. Struck out looking.

Dominique Baker @bakerdphd.bsky.social · 5d

Vanderbilt has arrived, late to the chat, with this shambles of a response. While technically true, this is a clear abdication of any moral responsibility. They even work in a mention of their commitment to "institutional neutrality" later in the email.

Screenshot from email that reads: Despite reporting to the contrary, we have not been asked to accept or reject the draft compact. Rather, we have been asked to provide feedback and comments as part of an ongoing dialogue, and that is our intention.

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Rebecca Spang @rlspang.bsky.social · 7d

I repeat myself: this is a town of 6000 people in Waldo County, Maine

Neal Harkness @nealharkness.bsky.social · 7d

#NoKings #BelfastMaine

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The Audacity! Creative Action Together in Midcoast Maine @theaudacitymaine.bsky.social · 8d

1700 people out for No Kings in rural Rockland, Maine today… more than 4% of the population of Knox County.

#NoKings #Maine #MEPolitics

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Gerald Weinand @dirigoblue.bsky.social · 8d

#NoKings rally Rockland Maine

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Zen Faulkes @doctorzen.net · 9d

Speculation: There has been a recency bias in citations for a long time, because the newer work should contain more up-to-date knowledge.

This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.

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Bri Barbu @bribarbu.bsky.social · 13d

Turns out, boron-based heterocycles are anything but boring! In fact, some of them are pretty magical...1,2-oxaborines, for example, can be used as precursors to 11(!) other ring systems!

Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...

These shape-shifting rings create customizable cores

1,2-oxaborines can shift into 11 different ring shapes to make modifying molecular cores easy

cen.acs.org

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J H @jpjh88.bsky.social · 14d

People need to start highlighting that Miller is actually the shadow President and the one calling the shots. When it was Musk who was doing it, it caused a rift between them so big that after he was out, Musk was bashing Trump claiming he is in the Epstein files.

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Dan Liebler @dliebler.bsky.social · 27d

True—BUT—setting aside the shameless jerks in the stands, the American players staged a thrilling comeback on Sunday to almost win it. In other words, there was an inspiring comeback that arose from the debacle. That is inspiration for America beyond golf.

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Eric Topol @erictopol.bsky.social · Sep 17

Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed.
www.nejm.org/doi/full/10....

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Dan Liebler @dliebler.bsky.social · Sep 10

Since I’m retired, I’ll take the bait. All measures are by definition quantitative. They differ in performance characteristics (linearity, measurement variation, repeatability, interference, specificity, etc). “Qualitative” is a useless adjective, mainly used as a highbrow insult.

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David Wessel @davidmwessel.bsky.social · Sep 9

Elaine Buckberg: To address "range anxiety," states should enact laws that require fast chargers to report real-time status that any EV mapping app can access via @brookings.edu Hutchins Center. www.brookings.edu/articles/cha...

Charger data transparency: Curing range anxiety, powering EV adoption | Brookings

Proposal for states to require fast chargers to report real-time status accessible by any EV mapping app, so drivers can reliably navigate to chargers.

www.brookings.edu

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Dan Liebler @dliebler.bsky.social · Sep 9

Well done.

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Dan Liebler @dliebler.bsky.social · Sep 3

That would require good questions and hypotheses instead of just the same ol’ proteomics numbers race.

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Phil Lewis @phillewis.bsky.social · Aug 28

70 years ago, on this date, Emmett Till was kidnapped and brutally murdered by white men.

His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary

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Dan Liebler @dliebler.bsky.social · Aug 28

I just retired, but I think if I were a younger investigator, I’d jump on this area. Mother Nature does not do random PTMs. Great analysis challenge that requires better technology. Great data analysis challenge. Needs better questions and hypotheses. Plenty of room for fresh thinking. Go!!

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Mark Zaid, Esq @markzaidesq.bsky.social · Aug 27

Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:

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Dan Liebler @dliebler.bsky.social · Aug 27

Roto

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Dan Liebler @dliebler.bsky.social · Aug 26

The Bayh-Dole Act has governed government funded university research and commercialization for decades. It provides the framework to enable these advances to be commercialized. Huge success, which drives most of biotech and pharma. Lifesaving.

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Dan Liebler @dliebler.bsky.social · Aug 25

Quality reps

Reposted by Dan Liebler

Nikolai Slavov @slavov-n.bsky.social · Aug 23

If you measure and interpret RNA levels in single cells, read this:

"𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙."

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Nikolai Slavov @slavov-n.bsky.social · Aug 22

Protein degradation is often considered as a final step in regulating gene expression.

It also regulates the first step: Transcription

Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.

👇

Slavov Laboratory @slavovlab.bsky.social · Aug 18

Protein synthesis is among the most energy demanding processes in a cell.

𝐖𝐡𝐲 𝐚𝐫𝐞 𝐭𝐡𝐞𝐧 𝐬𝐨𝐦𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧𝐬 𝐜𝐨𝐧𝐭𝐢𝐧𝐮𝐨𝐮𝐬𝐥𝐲 𝐬𝐲𝐧𝐭𝐡𝐞𝐬𝐢𝐳𝐞𝐝 𝐚𝐧𝐝 𝐢𝐦𝐦𝐞𝐝𝐢𝐚𝐭𝐞𝐥𝐲 𝐝𝐞𝐠𝐫𝐚𝐝𝐞𝐝 ?

blog.slavovlab.net/2025/08/16/p...

Proteins made to die

Protein synthesis is among the most energy-demanding processes in a cell. Yet, some proteins are synthesized and immediately degraded. This may seem like a futile cycle, but it’s a remarkable…

blog.slavovlab.net

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Moira Donegan @moiradonegan.bsky.social · Aug 22

The homeless are painful to look at because they remind us of how unfair our world is, of how much suffering it contains, of how arbitrary and undeserved and precarious our own comforts and health are, of how we have failed to be sufficiently generous and merciful to others.

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Dan Liebler @dliebler.bsky.social · Aug 8

talkingpointsmemo.com

Talking Points Memo | Breaking News and Analysis

Talking Points Memo (TPM) is an independent news organization that publishes reporting and analysis about American politics, public policy and political culture.

talkingpointsmemo.com

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