Dan Liebler
@dliebler.bsky.social
Retired biomedical scientist, consulting in chemistry and toxicology. Guitar is my lifelong pastime. I love steel string flattops.
Reposted by Dan Liebler
New preprint! We did a systematic comparison of proteases, digestion conditions, and labeling methods for histone PTM analysis by MS-based proteomics in the Yates lab at @scripps.edu.
TL;DR: you can get great results in ~3 h of sample prep. 🧵
TL;DR: you can get great results in ~3 h of sample prep. 🧵
February 16, 2026 at 10:34 PM
New preprint! We did a systematic comparison of proteases, digestion conditions, and labeling methods for histone PTM analysis by MS-based proteomics in the Yates lab at @scripps.edu.
TL;DR: you can get great results in ~3 h of sample prep. 🧵
TL;DR: you can get great results in ~3 h of sample prep. 🧵
Reposted by Dan Liebler
We need to get more mass spec proteomics folks on here and increase the size of our cluster!
#Proteomics #TeamMassSpec
bluesky-map.theo.io
#Proteomics #TeamMassSpec
bluesky-map.theo.io
February 9, 2026 at 4:19 PM
We need to get more mass spec proteomics folks on here and increase the size of our cluster!
#Proteomics #TeamMassSpec
bluesky-map.theo.io
#Proteomics #TeamMassSpec
bluesky-map.theo.io
Reposted by Dan Liebler
We'll pick it up from here.
Spring Training and the World Baseball Classic are right around the corner!
Spring Training and the World Baseball Classic are right around the corner!
February 9, 2026 at 3:23 AM
We'll pick it up from here.
Spring Training and the World Baseball Classic are right around the corner!
Spring Training and the World Baseball Classic are right around the corner!
Reposted by Dan Liebler
1. It was not an accident.
2. It was not a staffer.
3. While the president may have dementia his racism is not due to dementia.
4. He isn’t sorry. He means every racist thought he shares.
5. His base agrees with him.
6. He will do it again.
7. No one in power will hold him accountable.
2. It was not a staffer.
3. While the president may have dementia his racism is not due to dementia.
4. He isn’t sorry. He means every racist thought he shares.
5. His base agrees with him.
6. He will do it again.
7. No one in power will hold him accountable.
February 6, 2026 at 5:42 PM
1. It was not an accident.
2. It was not a staffer.
3. While the president may have dementia his racism is not due to dementia.
4. He isn’t sorry. He means every racist thought he shares.
5. His base agrees with him.
6. He will do it again.
7. No one in power will hold him accountable.
2. It was not a staffer.
3. While the president may have dementia his racism is not due to dementia.
4. He isn’t sorry. He means every racist thought he shares.
5. His base agrees with him.
6. He will do it again.
7. No one in power will hold him accountable.
Reposted by Dan Liebler
January 10, 2026 at 6:30 PM
Reposted by Dan Liebler
a few thoughts youtu.be/lERS4kJIQR8
Abolish ICE
YouTube video by Takes™ by Jamelle Bouie
youtu.be
January 8, 2026 at 1:42 AM
a few thoughts youtu.be/lERS4kJIQR8
Reposted by Dan Liebler
I’m proud to be leading this fight. Thank you to @maddowblog.bsky.social for highlighting this critical issue.
"The danger is once you compile all this information, then hackers only have to go to one place instead of going to all 50-plus jurisdictions that run elections... It’s a hacker’s dream to have all of this private, sensitive information collected somewhere..."
www.motherjones.com/politics/202...
www.motherjones.com/politics/202...
Trump’s DOJ is building a voter purge machine—powered by your private data
The federal agency ordinarily would prevent attacks on voting rights. Now it’s carrying them out.
www.motherjones.com
December 8, 2025 at 5:33 PM
I’m proud to be leading this fight. Thank you to @maddowblog.bsky.social for highlighting this critical issue.
Reposted by Dan Liebler
Our latest article is out in Cell !
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...
December 3, 2025 at 4:41 PM
Our latest article is out in Cell !
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...
Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential.
cell.com/cell/fulltex...
Reposted by Dan Liebler
An inspirational example of 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐜𝐫𝐞𝐚𝐭𝐢𝐯𝐢𝐭𝐲, 𝐨𝐫𝐢𝐠𝐢𝐧𝐚𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐢𝐠𝐨𝐫:
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
November 27, 2025 at 1:45 PM
An inspirational example of 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐜𝐫𝐞𝐚𝐭𝐢𝐯𝐢𝐭𝐲, 𝐨𝐫𝐢𝐠𝐢𝐧𝐚𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐢𝐠𝐨𝐫:
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
Reposted by Dan Liebler
I’ve been in Toronto at the #astmh meeting these past few days and last night some very good news was presented here: A new malaria drug has proven efficacious in a large trial and could soon be approved.🧪
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
‘A sigh of relief’: New malaria drug succeeds in large clinical trial
As existing drugs falter because of resistance, the world gets a backup—but hard choices loom on how to use it
www.science.org
November 13, 2025 at 1:27 PM
I’ve been in Toronto at the #astmh meeting these past few days and last night some very good news was presented here: A new malaria drug has proven efficacious in a large trial and could soon be approved.🧪
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
Reposted by Dan Liebler
Maine has voted in a landslide to reject a Republican-supported ballot initiative that would have restricted voting access heading into the critical 2026 midterms
Mainers defeat Republican effort to institute voter ID and limit absentee voting
The no side of Question 1 had 60.2% of votes to 39.8% for the yes side when the Bangor Daily News and its national partner, Decision Desk HQ, called the race at 9:26 p.m. Tuesday.
www.bangordailynews.com
November 5, 2025 at 2:40 AM
Maine has voted in a landslide to reject a Republican-supported ballot initiative that would have restricted voting access heading into the critical 2026 midterms
Turn the volume up!
November 5, 2025 at 4:37 AM
Turn the volume up!
Reposted by Dan Liebler
“Tell your children who the cowards were.”
October 27, 2025 at 10:19 PM
“Tell your children who the cowards were.”
Reposted by Dan Liebler
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com
October 26, 2025 at 5:02 PM
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
Reposted by Dan Liebler
Let's see how that government ban on White House demolition photos is going.
www.pbs.org/newshour/pol...
www.pbs.org/newshour/pol...
October 21, 2025 at 6:02 PM
Let's see how that government ban on White House demolition photos is going.
www.pbs.org/newshour/pol...
www.pbs.org/newshour/pol...
Vanderbilt response to the Trump ‘compact’ is too clever by half. Dodging the immoral dominance play and pretending it’s a reasoned conversation. Vandy wishes to play ball as an elite institution on a level with MIT, Penn and UVA. Struck out looking.
Vanderbilt has arrived, late to the chat, with this shambles of a response. While technically true, this is a clear abdication of any moral responsibility. They even work in a mention of their commitment to "institutional neutrality" later in the email.
October 20, 2025 at 10:09 PM
Vanderbilt response to the Trump ‘compact’ is too clever by half. Dodging the immoral dominance play and pretending it’s a reasoned conversation. Vandy wishes to play ball as an elite institution on a level with MIT, Penn and UVA. Struck out looking.
Reposted by Dan Liebler
I repeat myself: this is a town of 6000 people in Waldo County, Maine
October 18, 2025 at 8:09 PM
I repeat myself: this is a town of 6000 people in Waldo County, Maine
Reposted by Dan Liebler
1700 people out for No Kings in rural Rockland, Maine today… more than 4% of the population of Knox County.
#NoKings #Maine #MEPolitics
#NoKings #Maine #MEPolitics
October 18, 2025 at 5:44 PM
1700 people out for No Kings in rural Rockland, Maine today… more than 4% of the population of Knox County.
#NoKings #Maine #MEPolitics
#NoKings #Maine #MEPolitics
Reposted by Dan Liebler
Speculation: There has been a recency bias in citations for a long time, because the newer work should contain more up-to-date knowledge.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
October 17, 2025 at 12:35 PM
Speculation: There has been a recency bias in citations for a long time, because the newer work should contain more up-to-date knowledge.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
Reposted by Dan Liebler
Turns out, boron-based heterocycles are anything but boring! In fact, some of them are pretty magical...1,2-oxaborines, for example, can be used as precursors to 11(!) other ring systems!
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
These shape-shifting rings create customizable cores
1,2-oxaborines can shift into 11 different ring shapes to make modifying molecular cores easy
cen.acs.org
October 13, 2025 at 2:59 PM
Turns out, boron-based heterocycles are anything but boring! In fact, some of them are pretty magical...1,2-oxaborines, for example, can be used as precursors to 11(!) other ring systems!
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
Reposted by Dan Liebler
People need to start highlighting that Miller is actually the shadow President and the one calling the shots. When it was Musk who was doing it, it caused a rift between them so big that after he was out, Musk was bashing Trump claiming he is in the Epstein files.
October 12, 2025 at 5:26 PM
People need to start highlighting that Miller is actually the shadow President and the one calling the shots. When it was Musk who was doing it, it caused a rift between them so big that after he was out, Musk was bashing Trump claiming he is in the Epstein files.
Reposted by Dan Liebler
Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
September 17, 2025 at 10:24 PM
Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Dan Liebler
Elaine Buckberg: To address "range anxiety," states should enact laws that require fast chargers to report real-time status that any EV mapping app can access via @brookings.edu Hutchins Center. www.brookings.edu/articles/cha...
Charger data transparency: Curing range anxiety, powering EV adoption | Brookings
Proposal for states to require fast chargers to report real-time status accessible by any EV mapping app, so drivers can reliably navigate to chargers.
www.brookings.edu
September 9, 2025 at 1:10 PM
Elaine Buckberg: To address "range anxiety," states should enact laws that require fast chargers to report real-time status that any EV mapping app can access via @brookings.edu Hutchins Center. www.brookings.edu/articles/cha...
Reposted by Dan Liebler
70 years ago, on this date, Emmett Till was kidnapped and brutally murdered by white men.
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
August 28, 2025 at 1:14 PM
70 years ago, on this date, Emmett Till was kidnapped and brutally murdered by white men.
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary