Fernán Agüero
@ferag.bsky.social
Biologist | UNSAM-CONICET | Bioinformatics | Cheminformatics | Genomics | Drug discovery | Diagnostics | Neglected Tropical Diseases | Argentina 🇦🇷
Reposted by Fernán Agüero
Should an iconic #bacterial #chassis be renamed without community consensus? Our @mbio.bsky.social #article vindicates the established identity of #Pseudomonas putida KT2440 & argues for continuity, community practice & common sense in naming · @vdlorenzo.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe | mBio
Names matter; they are not mere labels. They operate as anchors of memory, social coordinates, and references of collective identity. When a name becomes established through long-term
use and broad ad...
journals.asm.org
January 27, 2026 at 7:43 PM
Should an iconic #bacterial #chassis be renamed without community consensus? Our @mbio.bsky.social #article vindicates the established identity of #Pseudomonas putida KT2440 & argues for continuity, community practice & common sense in naming · @vdlorenzo.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Fernán Agüero
Reposted by Fernán Agüero
Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money
1 in 8 'special issues' is filled with articles written by the editor, particularly at the publisher MDPI
@manuelansede.bsky.social
english.elpais.com/science-tech...
1 in 8 'special issues' is filled with articles written by the editor, particularly at the publisher MDPI
@manuelansede.bsky.social
english.elpais.com/science-tech...
Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money
An analysis of 100,000 special issues of academic journals reveals that one in eight is filled with articles written by the editor, particularly at the publisher MDPI
english.elpais.com
January 25, 2026 at 7:41 PM
Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money
1 in 8 'special issues' is filled with articles written by the editor, particularly at the publisher MDPI
@manuelansede.bsky.social
english.elpais.com/science-tech...
1 in 8 'special issues' is filled with articles written by the editor, particularly at the publisher MDPI
@manuelansede.bsky.social
english.elpais.com/science-tech...
Reposted by Fernán Agüero
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
rdcu.be
January 24, 2026 at 8:20 PM
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
Reposted by Fernán Agüero
The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA @cincyresearch.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
January 25, 2026 at 1:58 AM
The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA @cincyresearch.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Fernán Agüero
A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression.
More: rdcu.be/eXksT
More: rdcu.be/eXksT
Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap
Nature Communications - The vaccinia virus produces mRNA lacking the 5′ m7G cap structure. These uncapped mRNAs have long poly(A) leaders and dominate late in infection, suggesting a novel...
rdcu.be
January 5, 2026 at 8:41 AM
A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression.
More: rdcu.be/eXksT
More: rdcu.be/eXksT
Reposted by Fernán Agüero
This is really cool. Who said IgG can't protect the mucosae? #immunosky
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Mucosal immune responses to Bordetella pertussis in Gambian infants after maternal and primary vaccination: an immunological substudy of a single-centre, randomised, controlled, double-blind, phase 4 ...
Tdap–IPV vaccination during pregnancy induces antibodies that are transferred across
the placenta to reach the upper airway mucosa of the infant and could contribute to
local protection. Although mate...
www.thelancet.com
January 16, 2026 at 11:50 PM
This is really cool. Who said IgG can't protect the mucosae? #immunosky
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Fernán Agüero
#Virology
Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications
Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.
dlvr.it
January 16, 2026 at 4:47 PM
#Virology
Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
Reposted by Fernán Agüero
Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)?
This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec
This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec
Introducing Theropod. A set of python and R tools that I’ve put together to do STORI analysis with an external digital oscilloscope. pubs.acs.org/doi/10.1021/...
Theropod: Software Tools to Analyze Externally Collected Selective Temporal Overview of Resonant Ions
Recent developments in charge detection mass spectrometry have allowed for the broad characterization of individual proteoforms and mixtures of proteoforms from individual ions collected in Orbitrap m...
pubs.acs.org
January 17, 2026 at 2:39 AM
Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)?
This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec
This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec
Reposted by Fernán Agüero
This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
January 17, 2026 at 7:12 AM
This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
New Year, New Paper from the lab!
An enhanced fluorogenic phenotyping assay for screening of new drugs against Trypanosoma cruzi, the causative agent of #Chagas disease.
And two new antifungals with activity against T. cruzi!
@unsamoficial @CONICETDialoga @ebynunsam
🧵 1
An enhanced fluorogenic phenotyping assay for screening of new drugs against Trypanosoma cruzi, the causative agent of #Chagas disease.
And two new antifungals with activity against T. cruzi!
@unsamoficial @CONICETDialoga @ebynunsam
🧵 1
January 16, 2026 at 3:50 PM
New Year, New Paper from the lab!
An enhanced fluorogenic phenotyping assay for screening of new drugs against Trypanosoma cruzi, the causative agent of #Chagas disease.
And two new antifungals with activity against T. cruzi!
@unsamoficial @CONICETDialoga @ebynunsam
🧵 1
An enhanced fluorogenic phenotyping assay for screening of new drugs against Trypanosoma cruzi, the causative agent of #Chagas disease.
And two new antifungals with activity against T. cruzi!
@unsamoficial @CONICETDialoga @ebynunsam
🧵 1
Reposted by Fernán Agüero
I despise the coining of new acronyms.
Except this one: when is a paper in a special issue PISS (Published In Support of Self)? The answer, of course, is way too often.
Except this one: when is a paper in a special issue PISS (Published In Support of Self)? The answer, of course, is way too often.
We've got ISSUES. Literally.
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
January 13, 2026 at 5:12 PM
I despise the coining of new acronyms.
Except this one: when is a paper in a special issue PISS (Published In Support of Self)? The answer, of course, is way too often.
Except this one: when is a paper in a special issue PISS (Published In Support of Self)? The answer, of course, is way too often.
The Issue with Special Issues: when Guest Editors Publish in Support of Self. arxiv.org/abs/2601.07563
Thanks @hansonmark.bsky.social for putting the effort in documenting this plague.
We need to stop it. #PISS is damaging academia.
Thanks @hansonmark.bsky.social for putting the effort in documenting this plague.
We need to stop it. #PISS is damaging academia.
The Issue with Special Issues: when Guest Editors Publish in Support of Self
The recent exceptional growth in the number of special issues has led to the largest delegation of editorial power in the history of scientific publishing. Has this power been used responsibly? In thi...
arxiv.org
January 14, 2026 at 3:11 PM
The Issue with Special Issues: when Guest Editors Publish in Support of Self. arxiv.org/abs/2601.07563
Thanks @hansonmark.bsky.social for putting the effort in documenting this plague.
We need to stop it. #PISS is damaging academia.
Thanks @hansonmark.bsky.social for putting the effort in documenting this plague.
We need to stop it. #PISS is damaging academia.
Reposted by Fernán Agüero
Ever wonder why some projects just work and others slowly eat your soul? In this paper by @urialonlab.bsky.social discuss the importance of choosing both interesting and actually doable ideas. Impact matters as well as feasibility!
January 14, 2026 at 7:43 AM
Ever wonder why some projects just work and others slowly eat your soul? In this paper by @urialonlab.bsky.social discuss the importance of choosing both interesting and actually doable ideas. Impact matters as well as feasibility!
Reposted by Fernán Agüero
When you think you met the right phd advisor but then he stops answering emails
January 14, 2026 at 10:35 AM
When you think you met the right phd advisor but then he stops answering emails
Reposted by Fernán Agüero
Find out how to answer scientific questions about #ligands in the #PDB directly from your web browser. Watch the latest talk by Ibrahim Roshan at the CCP4 Study Weekend 2026.
🎥 Watch the talk:
ukri.zoom.us/rec/play/U_J...
#PDBeKB #CCP4 #StructuralBiology
🎥 Watch the talk:
ukri.zoom.us/rec/play/U_J...
#PDBeKB #CCP4 #StructuralBiology
January 14, 2026 at 10:46 AM
Find out how to answer scientific questions about #ligands in the #PDB directly from your web browser. Watch the latest talk by Ibrahim Roshan at the CCP4 Study Weekend 2026.
🎥 Watch the talk:
ukri.zoom.us/rec/play/U_J...
#PDBeKB #CCP4 #StructuralBiology
🎥 Watch the talk:
ukri.zoom.us/rec/play/U_J...
#PDBeKB #CCP4 #StructuralBiology
Reposted by Fernán Agüero
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
January 13, 2026 at 9:12 PM
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
Reposted by Fernán Agüero
🚀 #OpenProject 17.0 is here! We're excited about features such as:
📝 Real-time collaboration in Documents
🗂️ Programs + portfolios (Enterprise add-on)
🗓 Improved Meetings
🔎 Smarter global search
🛡️ Stronger privacy
🔗Please read: www.openproject.org/docs/release...
#Release #OpenSource #FOSS
📝 Real-time collaboration in Documents
🗂️ Programs + portfolios (Enterprise add-on)
🗓 Improved Meetings
🔎 Smarter global search
🛡️ Stronger privacy
🔗Please read: www.openproject.org/docs/release...
#Release #OpenSource #FOSS
January 14, 2026 at 10:59 AM
🚀 #OpenProject 17.0 is here! We're excited about features such as:
📝 Real-time collaboration in Documents
🗂️ Programs + portfolios (Enterprise add-on)
🗓 Improved Meetings
🔎 Smarter global search
🛡️ Stronger privacy
🔗Please read: www.openproject.org/docs/release...
#Release #OpenSource #FOSS
📝 Real-time collaboration in Documents
🗂️ Programs + portfolios (Enterprise add-on)
🗓 Improved Meetings
🔎 Smarter global search
🛡️ Stronger privacy
🔗Please read: www.openproject.org/docs/release...
#Release #OpenSource #FOSS
Reposted by Fernán Agüero
We've got ISSUES. Literally.
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
January 13, 2026 at 8:27 AM
We've got ISSUES. Literally.
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
Reposted by Fernán Agüero
🚨Bug bounty opportunity for ethical hackers:
#OpenProject has launched a public bug bounty program via #YesWeHack, supported by the European Commission.
Learn how to participate and help secure open source: www.openproject.org/blog/bug-bou...
#OpenSource #BugBounty #DigitalSovereignty
#OpenProject has launched a public bug bounty program via #YesWeHack, supported by the European Commission.
Learn how to participate and help secure open source: www.openproject.org/blog/bug-bou...
#OpenSource #BugBounty #DigitalSovereignty
January 12, 2026 at 8:47 AM
🚨Bug bounty opportunity for ethical hackers:
#OpenProject has launched a public bug bounty program via #YesWeHack, supported by the European Commission.
Learn how to participate and help secure open source: www.openproject.org/blog/bug-bou...
#OpenSource #BugBounty #DigitalSovereignty
#OpenProject has launched a public bug bounty program via #YesWeHack, supported by the European Commission.
Learn how to participate and help secure open source: www.openproject.org/blog/bug-bou...
#OpenSource #BugBounty #DigitalSovereignty
Reposted by Fernán Agüero
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
www.biorxiv.org
January 6, 2026 at 3:40 PM
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Fernán Agüero
The single most undervalued fact of linear algebra: matrices are graphs, and graphs are matrices.
Encoding matrices as graphs is a cheat code, making complex behavior simple to study.
Let me show you how!
Encoding matrices as graphs is a cheat code, making complex behavior simple to study.
Let me show you how!
January 1, 2026 at 2:36 PM
The single most undervalued fact of linear algebra: matrices are graphs, and graphs are matrices.
Encoding matrices as graphs is a cheat code, making complex behavior simple to study.
Let me show you how!
Encoding matrices as graphs is a cheat code, making complex behavior simple to study.
Let me show you how!
Reposted by Fernán Agüero
2025 was the year we stopped debating whether paying peer reviewers might work and started showing that it does.
December 31, 2025 at 10:13 PM
2025 was the year we stopped debating whether paying peer reviewers might work and started showing that it does.
Reposted by Fernán Agüero
All I want for Christmas is your feedback in our preprint!
Happy to share work from Daniil Lepikhov, Laura Sandner and me, where we show that including information from the enzyme-substrate interaction interface in deep learning models can improve the prediction of Michaelis constants. #compchem
Happy to share work from Daniil Lepikhov, Laura Sandner and me, where we show that including information from the enzyme-substrate interaction interface in deep learning models can improve the prediction of Michaelis constants. #compchem
December 20, 2025 at 12:50 PM
All I want for Christmas is your feedback in our preprint!
Happy to share work from Daniil Lepikhov, Laura Sandner and me, where we show that including information from the enzyme-substrate interaction interface in deep learning models can improve the prediction of Michaelis constants. #compchem
Happy to share work from Daniil Lepikhov, Laura Sandner and me, where we show that including information from the enzyme-substrate interaction interface in deep learning models can improve the prediction of Michaelis constants. #compchem
Reposted by Fernán Agüero
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!
December 19, 2025 at 4:35 PM
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!