Fernán Agüero
@ferag.bsky.social
Biologist | UNSAM-CONICET | Bioinformatics | Cheminformatics | Genomics | Drug discovery | Diagnostics | Neglected Tropical Diseases | Argentina 🇦🇷
Reposted by Fernán Agüero
Gatekeeping by demanding expensive technology or approaches is the ancient tactic of the rich laboratory.
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Heard an established successful neuroscientist dismissing junior scientists as "people at the bottom" 🤦♀️
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
November 23, 2025 at 6:30 PM
Gatekeeping by demanding expensive technology or approaches is the ancient tactic of the rich laboratory.
Reposted by Fernán Agüero
If you’re still hunting for color tools, I’m working on a more user-friendly version of meodai.github.io/poline/ keeping you huedrated
November 23, 2025 at 12:42 AM
If you’re still hunting for color tools, I’m working on a more user-friendly version of meodai.github.io/poline/ keeping you huedrated
Reposted by Fernán Agüero
This week's #RDKit blog post is the third in a series using the LOBSTER data set.
This time I use the data to compare 3D alignment methods.
greglandrum.github.io/rdkit-blog/p...
This time I use the data to compare 3D alignment methods.
greglandrum.github.io/rdkit-blog/p...
Working with the LOBSTER Data set III – RDKit blog
Comparing 3D alignment methods.
greglandrum.github.io
November 23, 2025 at 6:09 AM
This week's #RDKit blog post is the third in a series using the LOBSTER data set.
This time I use the data to compare 3D alignment methods.
greglandrum.github.io/rdkit-blog/p...
This time I use the data to compare 3D alignment methods.
greglandrum.github.io/rdkit-blog/p...
Reposted by Fernán Agüero
Example of bio::levenshtein in Rust mentioned in the post by Ash #Bioinformatics #DNA
November 23, 2025 at 7:35 AM
Example of bio::levenshtein in Rust mentioned in the post by Ash #Bioinformatics #DNA
Reposted by Fernán Agüero
We are thrilled to now be on BlueSky!
We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪
#OpenScience #MedSky
We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪
#OpenScience #MedSky
November 20, 2025 at 2:31 PM
We are thrilled to now be on BlueSky!
We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪
#OpenScience #MedSky
We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪
#OpenScience #MedSky
Reposted by Fernán Agüero
Reposted by Fernán Agüero
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Fernán Agüero
WE ARE RECRUITING PHD STUDENTS!!!
We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project.
#Drosophila #Evolution #Immunity #SelfishGene #Aphids
Thread with links below 🧵 1/4
We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project.
#Drosophila #Evolution #Immunity #SelfishGene #Aphids
Thread with links below 🧵 1/4
November 15, 2025 at 3:35 PM
WE ARE RECRUITING PHD STUDENTS!!!
We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project.
#Drosophila #Evolution #Immunity #SelfishGene #Aphids
Thread with links below 🧵 1/4
We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project.
#Drosophila #Evolution #Immunity #SelfishGene #Aphids
Thread with links below 🧵 1/4
Reposted by Fernán Agüero
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:35 AM
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Reposted by Fernán Agüero
I wrote something about publication bias at statmodeling.stat.columbia.edu/2025/11/14/t...
November 14, 2025 at 9:17 PM
I wrote something about publication bias at statmodeling.stat.columbia.edu/2025/11/14/t...
Reposted by Fernán Agüero
Gosh, it feels so good to finally have released Zensical on November 5! Together with the search, we've basically worked in the dark for 2 years – generally a very bad idea, as you can't know whether you nail the problem you're aiming to solve or not.
A thread ⬇ 1/4
A thread ⬇ 1/4
November 15, 2025 at 12:37 PM
Gosh, it feels so good to finally have released Zensical on November 5! Together with the search, we've basically worked in the dark for 2 years – generally a very bad idea, as you can't know whether you nail the problem you're aiming to solve or not.
A thread ⬇ 1/4
A thread ⬇ 1/4
Reposted by Fernán Agüero
A synthetic transcription cascade enables direct in planta shoot regeneration for transgenesis and gene editing in multiple plants #resource #MolecularPlant cell.com/molecular-pl...
November 15, 2025 at 12:50 PM
A synthetic transcription cascade enables direct in planta shoot regeneration for transgenesis and gene editing in multiple plants #resource #MolecularPlant cell.com/molecular-pl...
Reposted by Fernán Agüero
Direct shoot regeneration using Arabidopsis WIND1 (35S:AtWIND1) + pAtESR:IPT. The idea is WIND1 both reprograms and activates ESR promter, and subsequently activates cytokinin synthesis via pESR:IPT for shoot regeneration. #PlantScience
From: www.cell.com/molecular-pl...
From: www.cell.com/molecular-pl...
A synthetic transcription cascade enables direct in planta shoot regeneration for transgenesis and gene editing in multiple plants
This work presents an in planta system for inducing transgenic and gene-edited de
novo meristems via the wounding pathway. By combining the transcriptional regulator
WIND1 with developmental regulator...
www.cell.com
November 15, 2025 at 2:15 PM
Direct shoot regeneration using Arabidopsis WIND1 (35S:AtWIND1) + pAtESR:IPT. The idea is WIND1 both reprograms and activates ESR promter, and subsequently activates cytokinin synthesis via pESR:IPT for shoot regeneration. #PlantScience
From: www.cell.com/molecular-pl...
From: www.cell.com/molecular-pl...
Reposted by Fernán Agüero
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Fernán Agüero
Reposted by Fernán Agüero
Adding citations of people who might review the paper
November 14, 2025 at 10:06 AM
Adding citations of people who might review the paper
Reposted by Fernán Agüero
Imagine you could explicate the relationship between language and the world with the same precision we define any mathematical function! I mean, you can’t, but imagine you could!
I recently learned about the double bracket interpretation function in Linguistics and my fucking head almost exploded. I twisted myself in knots trying to write a paper that essentially explicates this (some differences, but generally this idea) and yeah…it’s so simple 💁♂️
November 13, 2025 at 11:47 PM
Imagine you could explicate the relationship between language and the world with the same precision we define any mathematical function! I mean, you can’t, but imagine you could!
Reposted by Fernán Agüero
Confusing stats language:
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
November 14, 2025 at 9:08 AM
Confusing stats language:
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
The "linear" is linear regression means "linear in the parameters".
It does not mean "can only fit straight lines", and things like polynomials and splines can be included in linear models.
online.stat.psu.edu/stat501/less...
1/2
Reposted by Fernán Agüero
🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
Nature Communications - The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric...
rdcu.be
November 12, 2025 at 11:15 AM
🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
Reposted by Fernán Agüero
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
November 12, 2025 at 10:38 AM
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
Reposted by Fernán Agüero
Tapping the XKCD sign again to explain that no, I won't be seeing an aurora tonight. Or at least I really hope not. That would be bad. :)
November 12, 2025 at 2:08 AM
Tapping the XKCD sign again to explain that no, I won't be seeing an aurora tonight. Or at least I really hope not. That would be bad. :)
Reposted by Fernán Agüero
The Next Open Revolution: Equity, Impact, and the Architecture of Knowledge scholarlykitchen.sspnet.org/2025/11/12/t...
The Next Open Revolution: Equity, Impact, and the Architecture of Knowledge - The Scholarly Kitchen
Today, Alison Mudditt reflects on a Charleston Conference session that asked: what would it take to make the scholarly communication system truly equitable, impactful, and future-ready?
scholarlykitchen.sspnet.org
November 12, 2025 at 11:05 AM
The Next Open Revolution: Equity, Impact, and the Architecture of Knowledge scholarlykitchen.sspnet.org/2025/11/12/t...
Reposted by Fernán Agüero
AlphaFold Database users can now temporarily integrate and visualise their own protein annotations, making the resource a more interactive and personalised platform for structural bioinformatics analysis.
www.ebi.ac.uk/about/news/u...
#AlphaFold
www.ebi.ac.uk/about/news/u...
#AlphaFold
AlphaFold Database launches custom annotations feature
The AlphaFold Database (AlphaFold DB) has introduced a new functionality that enables users to integrate and visualise custom sequence annotations. These annotations are processed in the browser for t...
www.ebi.ac.uk
November 11, 2025 at 2:23 PM
AlphaFold Database users can now temporarily integrate and visualise their own protein annotations, making the resource a more interactive and personalised platform for structural bioinformatics analysis.
www.ebi.ac.uk/about/news/u...
#AlphaFold
www.ebi.ac.uk/about/news/u...
#AlphaFold
Reposted by Fernán Agüero
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
November 11, 2025 at 8:35 AM
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
Reposted by Fernán Agüero
