flymuscles
@flymuscles.bsky.social
Assistant professor @Dalhousie University in Canada. We study # muscle function in #Drosophila. I bike to work.
https://flymuscles.wixsite.com/flymuscles
https://flymuscles.wixsite.com/flymuscles
Reposted by flymuscles
Mameli, Samantsidis, Viswanatha, Kwon, Hall, Butnaru, Hu., Y., Mohr, Perrimon and Smith (2025) A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes. 16(1):10323. doi: 10.1038/s41467-025-65304-y. PMID: 41285753
November 25, 2025 at 12:44 PM
Mameli, Samantsidis, Viswanatha, Kwon, Hall, Butnaru, Hu., Y., Mohr, Perrimon and Smith (2025) A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes. 16(1):10323. doi: 10.1038/s41467-025-65304-y. PMID: 41285753
Reposted by flymuscles
An open webinar on our reproducibility project 'WHAT 400 DROSOPHILA PAPERS Teach Us about Doing Better Science' on December 9th 2PM EEST time (1PM Swiss time). Registration below
November 24, 2025 at 4:31 PM
An open webinar on our reproducibility project 'WHAT 400 DROSOPHILA PAPERS Teach Us about Doing Better Science' on December 9th 2PM EEST time (1PM Swiss time). Registration below
Reposted by flymuscles
Latest work out today in @currentbiology.bsky.social
We find the fly development gene bicoid is much older than previously thought (~20 million yrs older!) 🪰🧬
To pinpoint its origins we tackled the Diptera phylogeny, providing some resolution (many open questions remain).
🔗 tinyurl.com/2vyuevpy
We find the fly development gene bicoid is much older than previously thought (~20 million yrs older!) 🪰🧬
To pinpoint its origins we tackled the Diptera phylogeny, providing some resolution (many open questions remain).
🔗 tinyurl.com/2vyuevpy
Revised evolutionary relationships within Brachycera and the early origin of bicoid in flies
Mulhair et al. uncover a functional bicoid in non-cyclorrhaphan flies, pushing the
gene's origin back by ∼20 million years. Reassessing the Diptera phylogeny using the
largest dataset to date permits ...
www.cell.com
October 17, 2025 at 3:14 PM
Latest work out today in @currentbiology.bsky.social
We find the fly development gene bicoid is much older than previously thought (~20 million yrs older!) 🪰🧬
To pinpoint its origins we tackled the Diptera phylogeny, providing some resolution (many open questions remain).
🔗 tinyurl.com/2vyuevpy
We find the fly development gene bicoid is much older than previously thought (~20 million yrs older!) 🪰🧬
To pinpoint its origins we tackled the Diptera phylogeny, providing some resolution (many open questions remain).
🔗 tinyurl.com/2vyuevpy
Reposted by flymuscles
Another AI cover art. Sigh
The second November issue is online.
-> www.embopress.org/toc/14693178...
The cover features work by Tina Mukherjee and co-workers showing that #macrophage metabolic #reprogramming during dietary stress influences adult body size in #Drosophila.
www.embopress.org/doi/full/10....
-> www.embopress.org/toc/14693178...
The cover features work by Tina Mukherjee and co-workers showing that #macrophage metabolic #reprogramming during dietary stress influences adult body size in #Drosophila.
www.embopress.org/doi/full/10....
November 22, 2025 at 9:40 AM
Another AI cover art. Sigh
Reposted by flymuscles
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
November 21, 2025 at 1:07 PM
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Reposted by flymuscles
Dear #Neuroscience researchers, I am Guest Editing an issue in @devdynamics.bsky.social on NEURAL MIGRATION.
Due date: March 31, 2026.
Great opportunity to showcase your findings on neural migration. #DevBio
Please reskeet 🙏
anatomypubs.onlinelibrary.wiley.com/journal/1097...
Due date: March 31, 2026.
Great opportunity to showcase your findings on neural migration. #DevBio
Please reskeet 🙏
anatomypubs.onlinelibrary.wiley.com/journal/1097...
Developmental Dynamics
<em>Developmental Dynamics</em> is a developmental biology journal publishing novel discoveries that advance our understanding in development, morphology, evolution, and disease.
anatomypubs.onlinelibrary.wiley.com
November 20, 2025 at 4:40 PM
Dear #Neuroscience researchers, I am Guest Editing an issue in @devdynamics.bsky.social on NEURAL MIGRATION.
Due date: March 31, 2026.
Great opportunity to showcase your findings on neural migration. #DevBio
Please reskeet 🙏
anatomypubs.onlinelibrary.wiley.com/journal/1097...
Due date: March 31, 2026.
Great opportunity to showcase your findings on neural migration. #DevBio
Please reskeet 🙏
anatomypubs.onlinelibrary.wiley.com/journal/1097...
Reposted by flymuscles
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
BigVolumeBrowser: a new 3D multi volume/mesh/point clould (SMLM) data viewer
Hello everyone, I’d like to share with you another 3D viewer for FIJI, BigVolumeBrowser (full documentation link). It‘s a first initial public release, so there is still space for improvements. Le...
forum.image.sc
November 21, 2025 at 9:29 AM
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
Reposted by flymuscles
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by flymuscles
OMG--read this thread. Remarkable clever use of a trick to visualize plasmid competition that reveals key insights into evolution!!!! 🧪
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 21, 2025 at 12:29 AM
OMG--read this thread. Remarkable clever use of a trick to visualize plasmid competition that reveals key insights into evolution!!!! 🧪
Reposted by flymuscles
How the Avalanche of Academic Papers Threatens Scientific Research, by Vince Bielski
'Editor-in-Chief Anna Stilz at @ucberkeleyofficial.bsky.social led a revolt that culminated in the mass resignation of the journal’s entire editorial staff and board.'
www.realclearinvestigations.com/articles/202...
'Editor-in-Chief Anna Stilz at @ucberkeleyofficial.bsky.social led a revolt that culminated in the mass resignation of the journal’s entire editorial staff and board.'
www.realclearinvestigations.com/articles/202...
How the Avalanche of Academic Papers Threatens Scientific Research
This is the third part of a series on academic publishing. Read part one here and part two here.
For many years, the prestigious journal Philosophy & Public Affairs published about
www.realclearinvestigations.com
November 20, 2025 at 9:39 AM
How the Avalanche of Academic Papers Threatens Scientific Research, by Vince Bielski
'Editor-in-Chief Anna Stilz at @ucberkeleyofficial.bsky.social led a revolt that culminated in the mass resignation of the journal’s entire editorial staff and board.'
www.realclearinvestigations.com/articles/202...
'Editor-in-Chief Anna Stilz at @ucberkeleyofficial.bsky.social led a revolt that culminated in the mass resignation of the journal’s entire editorial staff and board.'
www.realclearinvestigations.com/articles/202...
Reposted by flymuscles
A remarkable scientist, innovator, and role model--well worth a read. 🧪
Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...
Q & A
Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms
employed during early animal embryogenesis to specify cell fate, development, and
differentiation at Harvard Univ...
www.cell.com
November 20, 2025 at 12:04 PM
A remarkable scientist, innovator, and role model--well worth a read. 🧪
Reposted by flymuscles
NEW! We are hiring a Scientific Editor to join our amazing #PeerReview team. In this role, you'll help uphold rigorous peer review and support our editors, reviewers, and authors.
Applications are now open. Details here 📚▶️ https://ow.ly/X6WV50Xujv1
#NowHiring #ScienceJobs #AcademicPublishing
Applications are now open. Details here 📚▶️ https://ow.ly/X6WV50Xujv1
#NowHiring #ScienceJobs #AcademicPublishing
November 19, 2025 at 7:20 PM
NEW! We are hiring a Scientific Editor to join our amazing #PeerReview team. In this role, you'll help uphold rigorous peer review and support our editors, reviewers, and authors.
Applications are now open. Details here 📚▶️ https://ow.ly/X6WV50Xujv1
#NowHiring #ScienceJobs #AcademicPublishing
Applications are now open. Details here 📚▶️ https://ow.ly/X6WV50Xujv1
#NowHiring #ScienceJobs #AcademicPublishing
Reposted by flymuscles
Check out this tick I collected ;-)
And by collected, I mean pulled off my pant leg after a walk in the woods
And by collected, I mean pulled off my pant leg after a walk in the woods
November 19, 2025 at 8:29 PM
Check out this tick I collected ;-)
And by collected, I mean pulled off my pant leg after a walk in the woods
And by collected, I mean pulled off my pant leg after a walk in the woods
Reposted by flymuscles
📢Check out our latest #preprint list on FocalPlane
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...
Microscopy preprints – bioimage analysis - FocalPlane
Microscopy preprints – bioimage analysis - News
focalplane.biologists.com
November 18, 2025 at 10:07 AM
📢Check out our latest #preprint list on FocalPlane
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...
Reposted by flymuscles
You must have been looking forward to... October in preprints!
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
October in preprints - the Node
Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.
thenode.biologists.com
November 13, 2025 at 12:30 PM
You must have been looking forward to... October in preprints!
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
Reposted by flymuscles
Reposted by flymuscles
Poniendo los puntos sobre las íes 👏
Beigel, F., Brockington, D., Crosetto, P., Derrick, G., Fyfe, A., Barreiro, P. G., Hanson, M. A., Haustein, S., Larivière, V., Noe, C., Pinfield, S., & Wilsdon, J. (2025). The Drain of Scientific Publishing (No. arXiv:2511.04820). arXiv. doi.org/10.48550/arX...
Beigel, F., Brockington, D., Crosetto, P., Derrick, G., Fyfe, A., Barreiro, P. G., Hanson, M. A., Haustein, S., Larivière, V., Noe, C., Pinfield, S., & Wilsdon, J. (2025). The Drain of Scientific Publishing (No. arXiv:2511.04820). arXiv. doi.org/10.48550/arX...
The Drain of Scientific Publishing
The domination of scientific publishing in the Global North by major commercial publishers is harmful to science. We need the most powerful members of the research community, funders, governments and ...
doi.org
November 10, 2025 at 5:19 PM
Poniendo los puntos sobre las íes 👏
Beigel, F., Brockington, D., Crosetto, P., Derrick, G., Fyfe, A., Barreiro, P. G., Hanson, M. A., Haustein, S., Larivière, V., Noe, C., Pinfield, S., & Wilsdon, J. (2025). The Drain of Scientific Publishing (No. arXiv:2511.04820). arXiv. doi.org/10.48550/arX...
Beigel, F., Brockington, D., Crosetto, P., Derrick, G., Fyfe, A., Barreiro, P. G., Hanson, M. A., Haustein, S., Larivière, V., Noe, C., Pinfield, S., & Wilsdon, J. (2025). The Drain of Scientific Publishing (No. arXiv:2511.04820). arXiv. doi.org/10.48550/arX...
Reposted by flymuscles
Glad to share our latest work showing that #drosophila epigenetic enzyme TET controls muscle development independently of its catalytic activity but prevents muscle aging in a catalytic-dependent manner!
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging - Skeletal Muscle
Background Enzymes of the Ten-Eleven Translocation family are responsible for 5-methylcytosine (5mC) oxidation and play a key role in regulating DNA demethylation during various developmental processe...
links.springernature.com
October 27, 2025 at 3:23 PM
Glad to share our latest work showing that #drosophila epigenetic enzyme TET controls muscle development independently of its catalytic activity but prevents muscle aging in a catalytic-dependent manner!
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Reposted by flymuscles
Reposted by flymuscles
Nope. Read his words compiled by @lpachter.bsky.social and say that again. He was a stain on science from day 1
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
James Watson in his own words
“Some anti-Semitism is justified” “Whenever you interview fat people, you feel bad, because you know you’re not going to hire them” “Japan should be bombed for d…
liorpachter.wordpress.com
November 8, 2025 at 2:30 PM
Nope. Read his words compiled by @lpachter.bsky.social and say that again. He was a stain on science from day 1
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
lol so true
I didn't realize it was possible but those weird impersonal marketing spam e-mails have somehow gotten even more depressing now that they're being written by LLMs. At least before it was an actual human pretending to be interested in my work!
November 4, 2025 at 5:12 PM
lol so true
Reposted by flymuscles
A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration
Read this #LifelongDevSI #OA Research Article by John W. Quinn, Robin E. Harris and colleagues in our Stem Cells and Regeneration section doi.org/10.1242/dev....
Read this #LifelongDevSI #OA Research Article by John W. Quinn, Robin E. Harris and colleagues in our Stem Cells and Regeneration section doi.org/10.1242/dev....
October 31, 2025 at 5:53 PM
A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration
Read this #LifelongDevSI #OA Research Article by John W. Quinn, Robin E. Harris and colleagues in our Stem Cells and Regeneration section doi.org/10.1242/dev....
Read this #LifelongDevSI #OA Research Article by John W. Quinn, Robin E. Harris and colleagues in our Stem Cells and Regeneration section doi.org/10.1242/dev....
We desperately needed a cooling dry bath, but the typical brands are crazy expensive. So we got ourselves a
October 30, 2025 at 7:10 PM
We desperately needed a cooling dry bath, but the typical brands are crazy expensive. So we got ourselves a
Reposted by flymuscles
PAPER OUT ✨ What if you could use your microscope as a 3D printer? Prototype microfluidics in-house, <5$ in material costs per chip. From idea to experiment within a day. Now published in Lab-on-a-Chip (open-access): doi.org/10.1039/D5LC...
July 16, 2025 at 11:51 AM
PAPER OUT ✨ What if you could use your microscope as a 3D printer? Prototype microfluidics in-house, <5$ in material costs per chip. From idea to experiment within a day. Now published in Lab-on-a-Chip (open-access): doi.org/10.1039/D5LC...
Reposted by flymuscles
Nature Communications will publish ~10K papers in 2025 pubmed.ncbi.nlm.nih.gov?term=%22Natu...
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.
October 27, 2025 at 8:38 PM
Nature Communications will publish ~10K papers in 2025 pubmed.ncbi.nlm.nih.gov?term=%22Natu...
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.