“Brutal and traumatizing”: Interviews and a trove of internal documents show government officials and aid workers desperately tried to warn Trump advisers about impending disaster and death.

On the occasion of her 250th birthday, we invited Miss Jane Austen to cast a critical eye over our work. We are grateful for her kind attention

Measles in Texas, bird flu in Louisiana, tuberculosis in Kansas and Covid everywhere. Public health has been dying a slow death for years, we can’t count on it anymore. What can we count on? A mask!

Regular Covid vaccinations are needed to reduce associated cardiac risks, experts at the European Cardiology Society have concluded.

Dr. Anne Pham-Huy, a pediatric infectious disease specialist, debunks some common misconceptions about the flu and the flu shot

Ontario hospitals saw a 127 per cent spike in intensive care unit admissions stemming from influenza in just a week, the Ontario Hospital Association says.

A wave of groundbreaking research in Colorado is revealing how targeted measurement and interventions can transform air quality in schools, reduce illness, and help every child breathe easier.

Nirmatrelvir-ritonavir (NMV/r; Paxlovid) treatment reduces COVID-19-related morbidity, mortality, and direct healthcare burdens. To investigate the potential impact of NMV/r on indirect disease bur...

This paper describes within-host evolutionary dynamics of SARS-CoV-2 during an outbreak in three carnivore species. Positive selection and the emergence of potentially species-specific mutations were ...

Italian Journal of Pediatrics - Necrotizing enterocolitis (NEC) is a severe intestinal disease primarily affecting premature newborns, with high morbidity and mortality. Although typically linked...

AbstractAims. Patients with cardiovascular disease (CVD) have an increased risk of developing severe respiratory infections, including COVID-19. However, t

In this study, we pursued a structure-based drug discovery campaign targeting the SARS-CoV-2 helicase through three rounds of virtual screening (VS) enhanced with Artificial Intelligence (AI). The third round incorporated a deep neural network (DNN) in a virtual screening protocol to prioritize commercial molecules containing fragments related to previously identified hits. This model predicted binary activity toward the target and contributed to a 21% improvement in hit-identification efficiency compared with the previous approach, which used the same virtual screening protocol. In total, we have identified at least six hits with selectivity indexes (CC50/EC50) above three, which show promise in early stages of SARS-CoV-2 antiviral development. Additionally, a subfamily of 18 3-phenyl-1,2,3,4-tetrahydroisoquinoline (THIQ) derivatives was evaluated. The most potent compound identified in this series is MWAC-3429, which displayed cell-based antiviral activity (EC50 = 5.4 μM) with no observable cytotoxicity. The predicted binding site for this THIQ chemotype is located at the interface between the RecA1 and Stalk domains of Nsp13, where it appears to disrupt the 1B–RecA2 interdomain interactions, suggesting a novel allosteric inhibition mechanism, as supported by molecular dynamics simulations. Furthermore, five-membered ring substituents at the THIQ amino position were observed to enhance potency relative to their six-membered ring counterparts.

Long COVID is a major global health challenge but the underlying mechanisms are unclear, hampering the development of effective therapies. Evidence points to a causal link between thromboembolic proce...