Jigar Dadarwala
@jiggyd2027.bsky.social
P2 Student Pharmacist at the University of Pittsburgh
Glucocorticoids cut risk of death from #pneumonia in low-resource settings, trial shows
The results are likely to be more relevant to patients in sub-Saharan Africa than to those in high-resource settings, the authors say.
www.cidrap.umn.edu/p...
The results are likely to be more relevant to patients in sub-Saharan Africa than to those in high-resource settings, the authors say.
www.cidrap.umn.edu/p...
November 12, 2025 at 4:47 PM
Malaria in pregnancy causes adverse effects on the mother and fetus, requiring effective antimalarial treatment. In CID, authors examine the transplacental transfer of antimalarials to assess fetal safety and the risk of congenital malaria. https://bit.ly/4hSQGup
Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood
AbstractBackground. Malaria in pregnancy causes adverse effects on the mother and fetus, requiring effective antimalarial treatment. Understanding the tran
academic.oup.com
November 12, 2025 at 4:46 PM
COVID-19 Vaccination Linked to Reduced Infections in Children with Eczema.
“Our study suggests that COVID-19 vaccination not only protects against coronavirus but may also have broader health benefits for children with atopic dermatitis"
“Our study suggests that COVID-19 vaccination not only protects against coronavirus but may also have broader health benefits for children with atopic dermatitis"
COVID-19 Vaccination Linked to Reduced Infections in Children with Eczema - ACAAI Patient
Children with eczema may experience fewer allergic complications if they receive the COVID-19 vaccine, according to new research.
acaai.org
November 10, 2025 at 9:37 PM
Combined use of ibalizumab and lenacapavir for the treatment of multidrug-resistant HIV-1: A case series
✅ Just Accepted
🔗 https://bit.ly/47zMvQO
✅ Just Accepted
🔗 https://bit.ly/47zMvQO
November 10, 2025 at 9:36 PM
🧫 Alarming rise of superbugs in newborns
A study across Southeast Asia found most newborn sepsis cases were caused by drug-resistant bacteria, with Klebsiella and Acinetobacter showing especially high resistance.
🔗 www.thelancet.com/journals/lan...
#SciComm #Health #AMR 🧪
A study across Southeast Asia found most newborn sepsis cases were caused by drug-resistant bacteria, with Klebsiella and Acinetobacter showing especially high resistance.
🔗 www.thelancet.com/journals/lan...
#SciComm #Health #AMR 🧪
Pathogen distribution and antimicrobial resistance among neonatal bloodstream infections in Southeast Asia: results from NeoSEAP, a multicentre retrospective study
Neonatal sepsis in tertiary hospitals in Southeast Asia is predominantly caused by
gram-negative bacteria, with high rates of non-susceptibility to commonly prescribed
antibiotics.
www.thelancet.com
October 31, 2025 at 12:37 PM
In CID, Ornina Atieh, MD, and colleagues investigate the effect of semaglutide on cognitive function in people with #HIV and the possible mediation of this effect by changes in adiposity or inflammation. https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaf577/8287292
Effects of Semaglutide on Cognitive Function in People with HIV: A Randomized Controlled Trial
academic.oup.com
October 31, 2025 at 12:35 PM
Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant Enterococcus UTIs?
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46QolRz
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46QolRz
October 23, 2025 at 4:41 PM
Measles, polio, tuberculosis: what’s causing spikes in infectious diseases? www.nature.com/articles/d41...
Measles, polio, tuberculosis: what’s causing spikes in infectious diseases?
The huge power of vaccines is being diluted by hesitancy, funding cuts and conflict.
www.nature.com
October 23, 2025 at 4:41 PM
Healio: 'Study: Reinfection doubles children’s risk for long COVID'
"Eventually, hopefully, we can figure out how to better treat the different forms of long COVID.” - Ravi Jhaveri, MD, head of the division of infectious diseases, Lurie Children’s Hospital of Chicago
www.healio.com/news/pediatr...
"Eventually, hopefully, we can figure out how to better treat the different forms of long COVID.” - Ravi Jhaveri, MD, head of the division of infectious diseases, Lurie Children’s Hospital of Chicago
www.healio.com/news/pediatr...
Study: Reinfection doubles children’s risk for long COVID
Getting COVID-19 twice doubled children and adolescents’ risk for developing long COVID, according to data from the RECOVER trial published in The Lancet Infectious Diseases.Before this study, R...
www.healio.com
October 18, 2025 at 5:23 PM
When emerging fungal infections mimic tuberculosis: first reported case of invasive Emergomyces europaeus infection in a man with immunocompromise living in France
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4nIUDnB
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4nIUDnB
October 18, 2025 at 5:19 PM
In CID, Wuyan Zhang and colleagues evaluate whether participants with COVID-19 symptom recurrence and viral positivity after completion of nirmatrelvir/ritonavir treatment can benefit from a second course of treatment. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf548/8269311
Retreatment With Nirmatrelvir/Ritonavir Following Return of COVID-19 Symptoms and SARS-CoV-2 Positivity
Repeated nirmatrelvir/ritonavir treatment in participants with COVID-19 rebound was safe and well tolerated. In this group of participants, there was no cl
academic.oup.com
October 9, 2025 at 7:21 PM
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail
nature.com/articles/s41467-025-63463-6
nature.com/articles/s41467-025-63463-6
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail - Nature Communications
Rodrigues and Queiroz et al. report the discovery of Naiavirus, the largest enveloped virus, isolated from a Brazil biome. With an oval capsid and flexible tail, its giant genome holds many novel gene...
nature.com
October 9, 2025 at 7:20 PM
The duration of infectiousness following pulmonary tuberculosis treatment initiation is uncertain.
In CID, authors assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce new tuberculosis infections in household contacts. https://bit.ly/4pK8R9b
In CID, authors assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce new tuberculosis infections in household contacts. https://bit.ly/4pK8R9b
Reducing Household Tuberculosis Transmission: A Pilot Cluster-Randomized Controlled Trial
AbstractBackground. The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bu
academic.oup.com
October 1, 2025 at 2:24 AM
Clinical Outcome of Rifabutin-Based Treatment for Pulmonary Tuberculosis in Solid Organ Transplant Recipients
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46LL282
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46LL282
October 1, 2025 at 2:24 AM
International Application of an Optimized Harmonization Approach for Longitudinal Cognitive Data in People with HIV - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
International Application of an Optimized Harmonization Approach for Longitudinal Cognitive Data in People with HIV
We previously developed a refined longitudinal data harmonization method to address
the challenge of non-overlapping cognitive tests across cohorts, successfully harmonizing
data from five large-scale...
www.jclinepi.com
September 22, 2025 at 6:14 PM
"A systematic review and meta-analysis published in Open Forum Infectious Diseases reported a pooled prevalence of long COVID as 36% worldwide."
#LongCovid remains common and a public health emergency
www.eatg.org/hiv-news/mor...
#LongCovid remains common and a public health emergency
www.eatg.org/hiv-news/mor...
More than one-third of individuals with COVID-19 experience long COVID
Long COVID remains a globally persistent condition, with a pooled prevalence of 36% worldwide, highlighting the urgent need for follow-up studies and policy responses.
www.eatg.org
September 22, 2025 at 6:12 PM
🎉 Delighted to share the first pre-print from my lab where we demonstrate that intergenic DNA repeats mediate phase variation of the mucoid phenotype in hypervirulent Klebsiella pneumoniae: www.biorxiv.org/content/10.1... #klebclub
Simple Sequence Repeats Mediate Phase Variation of the Mucoid Phenotype in Hypervirulent Klebsiella pneumoniae
Hypervirulent Klebsiella pneumoniae (HVKp) express a thick mucoid capsular polysaccharide which is essential for virulence and survival in the bloodstream but inhibits epithelial adhesion and invasion...
www.biorxiv.org
September 19, 2025 at 11:43 AM
Costs of four months of rifampin versus two months of double-dose rifampin for tuberculosis infection: post-hoc analysis of a phase 2b randomized trial
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3IwFxCf
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3IwFxCf
September 19, 2025 at 11:36 AM
Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans | Science www.science.org/doi/10.1126/...
Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans
A leading HIV vaccine strategy requires a priming immunogen to induce broadly neutralizing antibody (bnAb) precursors, followed by a series of heterologous boosters to elicit somatic hypermutation (SH...
www.science.org
September 9, 2025 at 5:30 PM
Systematic #Corticosteroids Treatment Among Patients With #HIV and #Tuberculosis: This meta-analysis of 1410 HIV-positive TB patinete found that corticosteroid treatment neither significantly reduced all-cause mortality nor increased serious adverse events.
url: academic.oup.com/cid/article-...
url: academic.oup.com/cid/article-...
Efficacy and Safety of Systematic Corticosteroids Treatment Among Patients With HIV and Tuberculosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
This meta-analysis demonstrated corticosteroid treatment neither significantly reduced all-cause mortality nor increased serious adverse events.
academic.oup.com
September 9, 2025 at 5:27 PM
Estimating population immunity and impact of COVID-19 vaccination in Washington State and Oregon
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Estimating population immunity and impact of COVID-19 vaccination in Washington State and Oregon
The SARS-CoV-2 mRNA vaccine showed high clinical efficacy against the ancestral variant, but immunological waning, emergence of new variants, and the durability of infection-induced immunity complicate the estimation of population-level effectiveness.
bit.ly
September 9, 2025 at 5:26 PM
Characterizing treatment adherence trajectories in the endTB multisite cohort of drug-resistant tuberculosis patients: an application of group-based trajectory modelling
✅ Just Accepted
⭐ Editor's Choice
#IDSky
✅ Just Accepted
⭐ Editor's Choice
#IDSky
Characterizing treatment adherence trajectories in the endTB multisite cohort of drug-resistant tuberculosis patients: an application of group-based trajectory modelling
Using group-based modelling, we found that people with initially poor but improving adherence to multidrug-resistant TB treatment had outcomes comparable...
bit.ly
September 9, 2025 at 5:25 PM
An Emerging Human Infection with a Novel %Tickborne #Orthonairovirus Species in #China, as a cause of febrile illness. |
New England Journal of Medicine
www.nejm.org/doi/full/10....
New England Journal of Medicine
www.nejm.org/doi/full/10....
Human Infection with a Novel Tickborne Orthonairovirus Species in China | NEJM
This report describes a novel tickborne orthonairovirus species identified in patients
presenting with an acute febrile illness in China.
www.nejm.org
April 24, 2025 at 6:04 PM
Towards personalized medicine: the effect of treatment of chronic enterovirus diarrhea in an immunocompromised patient and the correlation with in vitro models
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Towards personalized medicine: the effect of treatment of chronic enterovirus diarrhea in an immunocompromised patient and the correlation with in vitro models
Enteroviruses (EV) usually cause acute, mild, self-limiting disease. Chronic infections with EVs are rare, and typically occur in patients with immunodeficiency, posing a high risk of severe outcomes.
doi.org
April 24, 2025 at 5:52 PM
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance
The 2024 WHO BPPL is a key tool for prioritising research and development investments
and informing global public health policies to combat AMR. Gram-negative bacteria
and rifampicin-resistant M tuber...
www.thelancet.com
April 17, 2025 at 1:30 PM