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Reposted by Jarrod Sandow

Chris Ashwood @cashwood.proteaglyco.com · Jun 30

Good reminder that there’s a free way to boost the dynamic range of your orbitrap-based instruments.

IonOpticks @ionopticks.bsky.social · Jun 29

MAP-MS overcomes dynamic range limitations in Orbitrap instruments.

Using an Exploris 480 with an EASY-nLC 1200 and Aurora Ultimate XT column, Phlairaharn et al. achieved a 9% increase in protein IDs for DDA and a 4% improvement for DIA, while halving quantitative variation.

bit.ly/4dYRZWF

Improving proteomic dynamic range with Multiple Accumulation Precursor Mass Spectrometry (MAP-MS) - IonOpticks

This study into improving proteomic dynamic range by Phlairaharn et al. used a 25 cm x 75 um IonOpticks Aurora Ultimate XT 15x75 UHPLC column

bit.ly

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Reposted by Jarrod Sandow

Michael MacCoss @maccoss.bsky.social · Jul 1

The Mag-Net paper is out! We've now put 1000s of plasma samples through this protocol and we know others have too. We've used it to study dozens of diseases. Looking forward to seeing what others apply this towards. The preprint already has >39 citations. www.nature.com/articles/s41...

Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome - Nature Communications

Authors report MagNet, a plasma extracellular vesicle (EV) enrichment strategy using magnetic beads. Proteomic interrogation of this plasma EV fraction enables the detection of proteins that are beyon...

www.nature.com

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Reposted by Jarrod Sandow

IonOpticks @ionopticks.bsky.social · Apr 24

New PCA-N workflow enables 10,000+ plasma samples/day using just 5µL per sample. Doubles protein coverage vs standard methods. Uses Evosep One LC with Orbitrap Astral MS, Aurora Rapid 8x150 column & EASY-Spray Source. Validated across 34,500 samples over 311 days.

Learn more: bit.ly/3RQd3o2

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Jarrod Sandow @jsandow.bsky.social · Mar 19

I'm excited to announce that we're expanding our leadership team at IonOpticks. We're searching for an exceptional Product Director with deep scientific expertise in chromatography and LC-MS to lead our Product Development team during an exciting phase of global growth.

Apply here:
bit.ly/43VoC4t

Product Director - LC-MS - SEEK

Exciting leadership opportunity to join an Aust-based tech company on a global mission to revolutionise the field of chromatography & proteomics.

bit.ly

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Reposted by Jarrod Sandow

Albert Heck @hecklab.bsky.social · Mar 15

Just out by Shelley Jager: rdcu.be/edEnO. One of the fastest & deepest plasma glycoproteomics studies. Take home message; we even detect glycosylated cytokines and chemokines, but also still need better software. #glycotime @utrechtuniversity.bsky.social @bijvoet-centre.bsky.social

In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer

Nature Communications - While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for...

rdcu.be

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Reposted by Jarrod Sandow

Shabaz Lab @shabazlab.bsky.social · Mar 7

Shout out to the organisers @jesperolsenlab.bsky.social, (Tina Ludwig) @baybioms.bsky.social kathrynslilley.bsky.social, Caroline May and Britta Eggers
and the speakers @bonalditiziana.bsky.social, @coscialab.bsky.social, @kusterlab.bsky.social, @anamdv.bsky.social, @jsandow.bsky.social

Shabaz Lab @shabazlab.bsky.social · Mar 7

The Brixen Proteomics Summer School speaker list has been finalised!. Lots of amazing science to be discussed! Big thanks to @eupaproteomics.bsky.social @msaid-de.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support

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Reposted by Jarrod Sandow

Shabaz Lab @shabazlab.bsky.social · Mar 7

The Brixen Proteomics Summer School speaker list has been finalised!. Lots of amazing science to be discussed! Big thanks to @eupaproteomics.bsky.social @msaid-de.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support

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Reposted by Jarrod Sandow

IonOpticks @ionopticks.bsky.social · Mar 4

“Habit becomes the enemy of innovation. And there’s a lot of space to innovate.”

Dr. Samantha Emery-Corbin, research fellow at the Monash Proteomics and Metabolomics Platform, discusses the art of scientific storytelling and potentially transformative sepsis treatment research.

bit.ly/41EGEXa

From Parasites to Proteomics: how Dr. Samantha Emery-Corbin is Bridging Biology and Big Data - IonOpticks

Interview with Dr Samantha Emery-Corbin, a research fellow at the Monash Proteomics and Metabolomics Platform in Melbourne.

bit.ly

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Reposted by Jarrod Sandow

ypic.bsky.social @ypic.bsky.social · Feb 18

❗Only 3 days left to register ❗Join our 2nd YPIC Annual Proteomics Gathering in Athens. One day with fruitful discussions, amazing presentations, and a lot of networking! Here is the link to register: docs.google.com/forms/d/e/1F...

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Reposted by Jarrod Sandow

Fan Liu @fan-liu.bsky.social · Jan 20

We have #postdoc openings in proteomics and structural+computational+cell biology. We offer cutting-edge infrastructure and an interdisciplinary engaging environment.

Check out our ongoing research and recent papers at www.theliulab.com

Interested? Message me here or at www.theliulab.com/contact

The Liu Lab

The Liu lab develops cross-linking and mass spectrometry methods to study protein structures and interactions in health and disease.

www.theliulab.com

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Reposted by Jarrod Sandow

IonOpticks @ionopticks.bsky.social · Jan 16

Breakthrough in FFPE Tissue Proteomics: Haines et al. develop new workflow for deep proteomic analysis of archived tissue samples.

Aurora Elite XT coupled with Orbitrap Astral to achieve precise peptide separation.

Read the full study: bit.ly/4gUVkqw

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Reposted by Jarrod Sandow

IonOpticks @ionopticks.bsky.social · Dec 24

A new manuscript from Karl Mechtler’s team investigates the optimal crosslinking mass spectrometry (CL-MS) workflow. As it turns out, the Orbitrap Astral + Aurora Ultimate is a powerful combination that opens up a completely new dimension for CL-MS.

Read the full manuscript over at bit.ly/41OlE0J

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Reposted by Jarrod Sandow

kmechtler.bsky.social @kmechtler.bsky.social · Dec 23

With this manuscript we would like to demonstrate the incredible power of the Orbitrap Astral for XL-MS. Over 40% more IDs than the Orbitrap Eclipse!
This opens up a completely new dimension for XL-MS.

www.biorxiv.org/content/10.1...

Breaking Barriers in Crosslinking Mass Spectrometry: Enhanced Throughput and Sensitivity with the Orbitrap Astral Mass Analyzer

The advancement of crosslinking mass spectrometry (CLMS) has significantly enhanced the ability to study protein-protein interactions and complex biological systems. This study evaluates the performan...

www.biorxiv.org

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Reposted by Jarrod Sandow

Pierre Sabatier @pierresabatier.bsky.social · Dec 18

Thanks for the highlight! @ionopticks.bsky.social

IonOpticks @ionopticks.bsky.social · Dec 18

Have you ever conducted an experiment with very little margin for error?

Pierre Sabatier (@pierresabatier.bsky.social) has. "That's the first time in my career that I felt like I absolutely needed to make it happen."

Learn more about Pierre and read our full discussion over at bit.ly/3VIWkpd

Pushing the boundaries: How Pierre Sabatier is helping to show that protein turnover can be studied in individual cells - IonOpticks

Pierre Sabatier, a proteomics researcher working at Uppsala University with Prof. Karl-Henrik Grinnemo as well as in Jesper Olsen’s lab at the Novo Nordisk Foundation Center for Protein Research, is …...

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Reposted by Jarrod Sandow

PastelBio @pastelbio.bsky.social · Dec 16

12 Proteomics Conference/Meetings already listed for 2025. Please let us know of others that are currently not present and also whether any are considered predatory and we'll remove them.

http://www.pastelbio...

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Reposted by Jarrod Sandow

Slavov Laboratory @slavovlab.bsky.social · Dec 15

Our protocol for multiplexed single-cell proteomics is in the Dec issue of Nature Protocols.

www.nature.com/articles/s41...

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Jarrod Sandow @jsandow.bsky.social · Dec 3

Unbox your Vipers! This is an entire cabinet of Vipers reduced to less than a shelf. Just make sure to curl them well to avoid the '90s style headphone cable tangle that resembles an Alphafold structure.

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Reposted by Jarrod Sandow

IonOpticks @ionopticks.bsky.social · Nov 26

Jarrod's epic mo deserves an epic photoshoot.
It all comes back to an epic cause though: supporting men's health. If you’d like to help make a difference, or you just respect the effort that Jarrod’s put in, you can donate here: movember.com/m/jarrodsand...

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Reposted by Jarrod Sandow

Alejandro Brenes @ajbrenes.com · Nov 10

#teamMassSpec here is a starting pack in case you just moved over, or in case you've been absent for a while. This is #proteomics or #massspec related. The pack is not comprehensive but it's a start.

go.bsky.app/HH7kqEh

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Reposted by Jarrod Sandow

IonOpticks @ionopticks.bsky.social · Nov 24

It’s exciting to see more and more studies coming in that use our recently launched Aurora Rapid 8x150 columns. In a new highlight, Heaton et al. investigate the role of LRRK2 mutations in Crohn's disease (CD) and Parkinson's disease (PD).

Learn more: bit.ly/3Z36Zfc

#LRRK2 #CrohnsDisease

Preprint: Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn’s Disease-Linked LRRK2-N2081D Variant - IonOpticks

This colitis severity study by Heaton et al. was conducted utilising an 8cm IonOpticks Aurora Rapid UHPLC column.

bit.ly

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Jarrod Sandow @jsandow.bsky.social · Nov 23

Any news on where iSCMS will be held in 2025?

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Reposted by Jarrod Sandow

kmechtler.bsky.social @kmechtler.bsky.social · Nov 21

It gives me great pleasure to announce our next European Single Cell Proteomics Conference www.apma.at/6thescp/
We would be delighted to receive many abstracts from students so that they have the opportunity to give their first presentation.
On behalf of: Erwin, Fabian, Manuel, Fabian and Karl

6th ESCP 2025 – APMA

www.apma.at

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Jarrod Sandow @jsandow.bsky.social · Nov 21

Me too please 😀

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Jarrod Sandow @jsandow.bsky.social · Nov 20

Can I be added to these lists please (except the ECR one......😬)

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