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Reposted by Sandra

Chise @sailorrooscout.bsky.social · 2h

Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

HIGHLIGHTS
•Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons
• NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells
• NPs improve tumor-free outcomes with memory against multiple aggressive tumor models
SUMMARY
We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines.
Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other
proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages.
Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells.

Graphical Abstract

The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.

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Chise @sailorrooscout.bsky.social · 2h

GOOD NEWS! Researchers have developed a cancer vaccine that has shown STUNNING results, PREVENTING up to 88% of MULTIPLE aggressive cancers by harnessing dual-pathway nanoparticles that train the immune system to recognize and destroy tumor cells. In some cases, it COMPLETELY prevented metastasis.

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Nicholas Grossman @nicholasgrossman.bsky.social · 6h

“Who was president in 2020?” remains one of the most pertinent questions in American politics—absurd, yes, but here we are—and that extends to “who was president January 1 - 19, 2021?”

Joyce White Vance @joycewhitevance.bsky.social · 6h

That’s a nice trick, since Biden wasn’t the president on Jan 6.

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southpaw @nycsouthpaw.bsky.social · 4h

The deportation order is based on Vedam’s conviction for murder—a crime he did not actually commit and for which he’s now been wholly exonerated. He entered the US at 9 months old and was a legal permanent resident before his conviction. We are so, so, so far from the light of justice.

Lynn Becker @cmgiulini.bsky.social · 16h

After spending 43 years in prison for a crime he didn't commit, evidence hidden by the prosecution reversed his conviction. Rather than finally enjoying freedom, ICE abducted him for deportation

Depraved.

www.miamiherald.com/news/local/i...

He was wrongfully imprisoned for 43 years. Moments after being released, ICE took him

Subramanyam “Subu” Vedam now faces deportation.

www.miamiherald.com

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Marc Elias @marcelias.bsky.social · 5h

This has real -- I intended to dm "Pam" -- energy.

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Sandra @lilysch.bsky.social · 5h

Credit: Pitch Interactive and Amanda Montañez

A complicated figure titled The Gender Spectrum by Pitch Interactive and Amanda Montañez explaining the biological basis for different human sex phenotypes. There is more than two sexes

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Sandra @lilysch.bsky.social · 5h

Surprise, surprise.🙄

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Beefeater Fella @beefeaterfella.bsky.social · 17h

Russia media boasting about using Nepalese in their ranks

“Nepal with Russians in the Special Military Operation

Our ranks have grown. Volunteers from the South Asian republic are mastering Russian weapons and preparing for combat missions.

1/6

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Reposted by Sandra

Congresswoman Pramila Jayapal @jayapal.house.gov · 3d

Last night, I received notification of the 19th death of a detained person in ICE custody since Trump took office.

ICE is detaining people, mostly in private, for-profit prisons that put profit over health. And now they have furloughed the safety inspectors. This is unacceptable.

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Joshua Weitz @joshuasweitz.bsky.social · 14h

Unknown gap between number fired on Friday and unfired on Saturday and as before in previous "errors", message is clear: admin doesn't care about federal workers or their mission.

open.substack.com/pub/joshuasw...

With Malice Toward All and Charity for None: Oct. 10-11 CDC (Un)Firing Edition

A post interpreting the Friday night firing of more than 1,000 CDC experts only to have some of these layoffs termed an ‘error’ & reversed on Saturday night.

open.substack.com

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Reposted by Sandra

Josh Marshall @joshtpm.bsky.social · 14h

Fridays firings www.nytimes.com/2025/10/11/h...

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Sandra @lilysch.bsky.social · 14h

Also: scooping up a man about to be released after being wrongfully imprisoned for 43 years.

bsky.app/profile/cmgi...

Lynn Becker @cmgiulini.bsky.social · 16h

After spending 43 years in prison for a crime he didn't commit, evidence hidden by the prosecution reversed his conviction. Rather than finally enjoying freedom, ICE abducted him for deportation

Depraved.

www.miamiherald.com/news/local/i...

He was wrongfully imprisoned for 43 years. Moments after being released, ICE took him

Subramanyam “Subu” Vedam now faces deportation.

www.miamiherald.com

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Reposted by Sandra

Little Miss FAFO @nofuxgiven.bsky.social · 14h

Let me be clear, that 15 year old CHILD will be TRAUMATIZED over this. Even the Mafia says “no women-no children”. WTF!!!

This now has become something way bigger. The question is, what are WE going to do?

Something NEEDS to stop this. It makes me physically ill.

Share this EVERYWHERE

Joshua Reed Eakle 🗽 @joshuaeakle.com · 1d

In Chicago, four vehicles descended and eight ICE agents moved in to kidnap a child.

She screams, “I’m 15,” as ICE yanks her from the car and kneels on her neck.

This is not about immigration enforcement.

It's about terrorizing Americans.

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Sandra @lilysch.bsky.social · 14h

A system and an organization that would also scoop up a man that had been wrongfully detained for 43 YEARS on his way out of prison.

bsky.app/profile/cmgi...

Lynn Becker @cmgiulini.bsky.social · 16h

After spending 43 years in prison for a crime he didn't commit, evidence hidden by the prosecution reversed his conviction. Rather than finally enjoying freedom, ICE abducted him for deportation

Depraved.

www.miamiherald.com/news/local/i...

He was wrongfully imprisoned for 43 years. Moments after being released, ICE took him

Subramanyam “Subu” Vedam now faces deportation.

www.miamiherald.com

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Sandra @lilysch.bsky.social · 14h

Only extraordinary evil people would order this. How are these people living with themselves.

Lynn Becker @cmgiulini.bsky.social · 16h

After spending 43 years in prison for a crime he didn't commit, evidence hidden by the prosecution reversed his conviction. Rather than finally enjoying freedom, ICE abducted him for deportation

Depraved.

www.miamiherald.com/news/local/i...

He was wrongfully imprisoned for 43 years. Moments after being released, ICE took him

Subramanyam “Subu” Vedam now faces deportation.

www.miamiherald.com

Reposted by Sandra

Lynn Becker @cmgiulini.bsky.social · 16h

After spending 43 years in prison for a crime he didn't commit, evidence hidden by the prosecution reversed his conviction. Rather than finally enjoying freedom, ICE abducted him for deportation

Depraved.

www.miamiherald.com/news/local/i...

He was wrongfully imprisoned for 43 years. Moments after being released, ICE took him

Subramanyam “Subu” Vedam now faces deportation.

www.miamiherald.com

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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · May 30

No words

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Catherine Rampell @crampell.bsky.social · 22h

Per CDC source: At internal leadership meeting this afternoon, it was shared that 1,257 people were RIF'd at CDC. Number may not be final. Apparently, chief of staff was unaware that RIFs were going to occur so not clear who is making decisions. (Short 🧵)

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Sheryl Gay Stolberg @sherylnyt.bsky.social · 17h

Whoops! You’re not RIF’d after all .

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Sheryl Gay Stolberg @sherylnyt.bsky.social · 19h

OOOPS! UPDATE: Two HHS officials tell me that disease detectives, measles response officers, global health officials and the MMWR staff were laid off by mistake and will be reinstated. But Washington office is still RIFed

Sheryl Gay Stolberg @sherylnyt.bsky.social · 1d

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

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Sandra @lilysch.bsky.social · 14h

The 300 kg of peaches all ripen within the same two days.

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Sandra @lilysch.bsky.social · 14h

As an ex-Catholic, I‘m very impressed by Father Larry. Cannot believe they took the monstrance out of church!

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Claire Willett @clairewillett.bsky.social · 14h

this is more than just marching in full regalia to Broadview and praying outside of it

this is very deftly trapping ICE into the position of having to literally - LITERALLY, to them - turn Christ away from the door

any Catholic ICE officer was probably shook, I’m really not exaggerating

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Claire Willett @clairewillett.bsky.social · 15h

found exactly the one use of “evil recoils in the presence of Christ” I am willing to sign off on, HOOOOOOOOLY SHIT

Father Larry did not come here to fuck around

Rich Raho @richraho.bsky.social · 21h

Chicago priest Fr. Larry Dowling describes procession to ICE facility: “No one had the courage to speak directly to us. No one from Homeland Security could stand in the presence of the Monstrance holding the Blessed Sacrament. No wonder. Evil is repelled, recoils in the presence of Christ.”

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Rich Raho @richraho.bsky.social · 21h

Chicago priest Fr. Larry Dowling describes procession to ICE facility: “No one had the courage to speak directly to us. No one from Homeland Security could stand in the presence of the Monstrance holding the Blessed Sacrament. No wonder. Evil is repelled, recoils in the presence of Christ.”

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