Lucas Schirmer
@lschirmer.bsky.social
220 followers
130 following
13 posts
Neurologist physician-scientist at Heidelberg University interested in chronic neuroinflammation and how to improve resilience in muscle and brain diseases. Check out @schirmerlab.bsky.social and www.schirmerlab.com for lab.
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Lucas Schirmer
@lschirmer.bsky.social
· Dec 5
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions - Nature Neuroscience
Lerma-Martin et al. generated a paired single-nucleus RNA sequencing and spatial transcriptomics dataset from subcortical multiple sclerosis lesions, identifying spatial niches and key cell interactio...
www.nature.com
Reposted by Lucas Schirmer
Reposted by Lucas Schirmer
Lucas Schirmer
@lschirmer.bsky.social
· Feb 21
Anshul Kundaje
@anshulkundaje.bsky.social
· Feb 21
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
www.science.org
Lucas Schirmer
@lschirmer.bsky.social
· Jan 27
Marek Bartosovic
@mardzix.bsky.social
· Jan 27
Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues - Nature Methods
Spatial-Mux-seq offers a multimodal spatial platform capable of profiling multiple molecular modalities, including the transcriptome, chromatin accessibility, histone modifications and targeted protei...
www.nature.com
Reposted by Lucas Schirmer
Reposted by Lucas Schirmer
Fabian Theis
@fabiantheis.bsky.social
· Jan 22
Mapping cells through time and space with moscot - Nature
Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal...
www.nature.com
Lucas Schirmer
@lschirmer.bsky.social
· Jan 19
Ethan Hughes
@ethanhugheslab.bsky.social
· Jan 18
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications
Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...
www.nature.com
Reposted by Lucas Schirmer
Nature Neuroscience
@natneuro.nature.com
· Jan 10
Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus - Nature Neuroscience
Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand age-related molecular chan...
www.nature.com
Reposted by Lucas Schirmer
Eric Topol
@erictopol.bsky.social
· Jan 8
A foundation model of transcription across human cell types - Nature
A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...
www.nature.com
Reposted by Lucas Schirmer
Reposted by Lucas Schirmer
Wolfgang Huber
@wkhuber.bsky.social
· Jan 3
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
doi.org
Lucas Schirmer
@lschirmer.bsky.social
· Dec 26
Multiple Sclerosis: Glial Cell Diversity in Time and Space
Glial cells and their subtypes are key drivers of lesion progression in multiple sclerosis with roles in both tissue damage and repair depending on the surrounding tissue environment and the function....
onlinelibrary.wiley.com
Reposted by Lucas Schirmer
Anshul Kundaje
@anshulkundaje.bsky.social
· Dec 25
Lucas Schirmer
@lschirmer.bsky.social
· Dec 22
Lucas Schirmer
@lschirmer.bsky.social
· Dec 21
Reposted by Lucas Schirmer
Neuron
@cp-neuron.bsky.social
· Dec 20
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses
Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patients into groups based on patterns of gene expression in…
dlvr.it
Lucas Schirmer
@lschirmer.bsky.social
· Dec 19
BrunetLab
@brunetlab.bsky.social
· Dec 18
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
Reposted by Lucas Schirmer
Priya Prakash
@pryprk.bsky.social
· Dec 17
Lipids: Emerging Players of Microglial Biology
Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...
onlinelibrary.wiley.com
Reposted by Lucas Schirmer
Shane Liddelow
@liddelowsa.bsky.social
· Dec 11
