Melike Lakadamyali
@melikel.bsky.social
Professor, Physiology Department, Perelman School of Medicine, University of Pennsylvania. https://www.lakadamyali-lab.com
Super resolution microscopy, single molecule biophysics, microtubules, organelles, nucleus and chromatin
Super resolution microscopy, single molecule biophysics, microtubules, organelles, nucleus and chromatin
Reposted by Melike Lakadamyali
Last call for Les Houches! Apply now or never! ;) (ok, in 2 years again then) and share with your friends.
Please share: The application for Les Houches is open (until Oct 31)
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
French-German WE-Heraeus-Seminar "Fluorescence markers for advanced microscopy : From photophysics to biology - 2026"
March 15-20 2026, Les Houches, France
fluorescenceleshouches.wordpress.com
October 22, 2025 at 7:00 PM
Last call for Les Houches! Apply now or never! ;) (ok, in 2 years again then) and share with your friends.
Reposted by Melike Lakadamyali
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA
Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...
forum.image.sc
October 7, 2025 at 12:39 PM
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Reposted by Melike Lakadamyali
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Melike Lakadamyali
Erdinc Sezgin to Receive 2026 Early Independent Career Award
www.biophysics.org/news-room/er...
www.biophysics.org/news-room/er...
September 24, 2025 at 6:30 PM
Erdinc Sezgin to Receive 2026 Early Independent Career Award
www.biophysics.org/news-room/er...
www.biophysics.org/news-room/er...
Congratulations @jiexiaolab.bsky.social . This is so well deserved.
Jie Xiao to Receive 2026 Carolyn Cohen Innovation Award
www.biophysics.org/news-room/ji...
www.biophysics.org/news-room/ji...
September 24, 2025 at 7:22 PM
Congratulations @jiexiaolab.bsky.social . This is so well deserved.
Reposted by Melike Lakadamyali
Jie Xiao to Receive 2026 Carolyn Cohen Innovation Award
www.biophysics.org/news-room/ji...
www.biophysics.org/news-room/ji...
September 24, 2025 at 7:13 PM
Jie Xiao to Receive 2026 Carolyn Cohen Innovation Award
www.biophysics.org/news-room/ji...
www.biophysics.org/news-room/ji...
Reposted by Melike Lakadamyali
Sarah Veatch to Receive 2026 Agnes Pockels Award in Lipids and Membrane Biophysics buff.ly/AdSMhCT
September 24, 2025 at 4:58 PM
Sarah Veatch to Receive 2026 Agnes Pockels Award in Lipids and Membrane Biophysics buff.ly/AdSMhCT
Congratulations to @ceesdekker.bsky.social . This is so well deserved!
Cornelis (Cees) Dekker to Receive the 2026 Kazuhiko Kinosita Award in Single-Molecule Biophysics buff.ly/fIexyZu
September 24, 2025 at 5:47 PM
Congratulations to @ceesdekker.bsky.social . This is so well deserved!
Reposted by Melike Lakadamyali
Cornelis (Cees) Dekker to Receive the 2026 Kazuhiko Kinosita Award in Single-Molecule Biophysics buff.ly/fIexyZu
September 24, 2025 at 5:45 PM
Cornelis (Cees) Dekker to Receive the 2026 Kazuhiko Kinosita Award in Single-Molecule Biophysics buff.ly/fIexyZu
Reposted by Melike Lakadamyali
Please share: The application for Les Houches is open (until Oct 31)
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
French-German WE-Heraeus-Seminar "Fluorescence markers for advanced microscopy : From photophysics to biology - 2026"
March 15-20 2026, Les Houches, France
fluorescenceleshouches.wordpress.com
September 12, 2025 at 9:03 AM
Please share: The application for Les Houches is open (until Oct 31)
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
Reposted by Melike Lakadamyali
@embl.org Heidelberg is looking for a new Head of Scientific Instrumentation! This is an exciting opportunity at the interface between scientific research and technology development, overseeing our mechanical and electronic workshops!
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Head of Scientific Instrumentation Workshops
EMBL is a world leader in scientific research and at the forefront in the development of cutting-edge technologies. It operates across six sites in Heidelberg (headquarters), Barcelona, Cambridge, Gre...
embl.wd103.myworkdayjobs.com
September 12, 2025 at 6:48 PM
@embl.org Heidelberg is looking for a new Head of Scientific Instrumentation! This is an exciting opportunity at the interface between scientific research and technology development, overseeing our mechanical and electronic workshops!
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Reposted by Melike Lakadamyali
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
September 12, 2025 at 6:17 AM
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Reposted by Melike Lakadamyali
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...
www.biorxiv.org
August 14, 2025 at 7:01 PM
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Reposted by Melike Lakadamyali
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Melike Lakadamyali
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
August 7, 2025 at 6:12 PM
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
I’m excited to start my sabbatical at the EMBL in beautiful Heidelberg hosted by @sinemsaka.bsky.social Looking forward to learning more about DNA barcoding technologies, spatial omics, MINFLUX and more. Really excited about the exchange with all the amazing scientists at EMBL!
August 9, 2025 at 12:08 PM
I’m excited to start my sabbatical at the EMBL in beautiful Heidelberg hosted by @sinemsaka.bsky.social Looking forward to learning more about DNA barcoding technologies, spatial omics, MINFLUX and more. Really excited about the exchange with all the amazing scientists at EMBL!
Reposted by Melike Lakadamyali
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
Home | Research Group Schmid | University of Basel
schmid.chemie.unibas.ch
July 31, 2025 at 2:34 PM
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
Reposted by Melike Lakadamyali
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications
A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...
www.nature.com
July 21, 2025 at 10:53 AM
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Reposted by Melike Lakadamyali
🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)
July 10, 2025 at 8:34 AM
🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)
Reposted by Melike Lakadamyali
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
July 4, 2025 at 3:50 PM
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Reposted by Melike Lakadamyali
Out latest preprint, from @cpane94.bsky.social in the lab, is out today!
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
June 19, 2025 at 1:01 AM
Out latest preprint, from @cpane94.bsky.social in the lab, is out today!
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
Reposted by Melike Lakadamyali
👇 Reminder on deadlines for i) early bird, ii) free child care option and iii) abstract talk selection! 👇
Short reminder:
*Early bird deadline approaching on June 27th*! While you of course can still register afterwards, *free child care* and *abstract selection* need some organizational time and thus will run out with this deadline!
--> So, please register rather sooner than later! Thanks!
*Early bird deadline approaching on June 27th*! While you of course can still register afterwards, *free child care* and *abstract selection* need some organizational time and thus will run out with this deadline!
--> So, please register rather sooner than later! Thanks!
June 11, 2025 at 11:51 PM
👇 Reminder on deadlines for i) early bird, ii) free child care option and iii) abstract talk selection! 👇
Reposted by Melike Lakadamyali
👉🏻 so glad to see this work out now ... a masterpiece conceived, led and driven by 👉🏻 Christoph Spahn 👏@michriscopy.bsky.social (🚨 #NewPI) and with great collaborations 🙏 @henriqueslab.bsky.social @seamusholden.bsky.social @gomez-mariscal.bsky.social
Into the Nucleoid:
Single-molecule localisation 🔬 and live-cell imaging reveal fine details of chromosomal organisation in the bacterium E. coli 🦠
@michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social
#microbiology
Single-molecule localisation 🔬 and live-cell imaging reveal fine details of chromosomal organisation in the bacterium E. coli 🦠
@michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social
#microbiology
BPoD | Into the Nucleoid
Into the Nucleoid - Biomedical pictures for April 2025.
bit.ly
May 31, 2025 at 6:12 AM
👉🏻 so glad to see this work out now ... a masterpiece conceived, led and driven by 👉🏻 Christoph Spahn 👏@michriscopy.bsky.social (🚨 #NewPI) and with great collaborations 🙏 @henriqueslab.bsky.social @seamusholden.bsky.social @gomez-mariscal.bsky.social
Reposted by Melike Lakadamyali
Here: Baby KJ at home with his mom Nicole.
This really happened, folks. Hundreds of people from 8 organizations (led by Rebecca Ahrens-nicklas and Kiran Musunuru) came together to make a bespoke gene editor for this kiddo. He was once in the 7th percentile of body weight. Look at him now! ❤️
This really happened, folks. Hundreds of people from 8 organizations (led by Rebecca Ahrens-nicklas and Kiran Musunuru) came together to make a bespoke gene editor for this kiddo. He was once in the 7th percentile of body weight. Look at him now! ❤️
June 4, 2025 at 10:43 AM
Here: Baby KJ at home with his mom Nicole.
This really happened, folks. Hundreds of people from 8 organizations (led by Rebecca Ahrens-nicklas and Kiran Musunuru) came together to make a bespoke gene editor for this kiddo. He was once in the 7th percentile of body weight. Look at him now! ❤️
This really happened, folks. Hundreds of people from 8 organizations (led by Rebecca Ahrens-nicklas and Kiran Musunuru) came together to make a bespoke gene editor for this kiddo. He was once in the 7th percentile of body weight. Look at him now! ❤️
Reposted by Melike Lakadamyali
In case you needed a smile this Tuesday: 10-month-old baby KJ, who received a bespoke gene-editing therapy after a six month scientific sprint - "graduated" from the hospital @childrensphila.bsky.social today and went HOME!
YAY SCIENCE!
Here's his story: wapo.st/451ZQjT
YAY SCIENCE!
Here's his story: wapo.st/451ZQjT
June 3, 2025 at 8:39 PM
In case you needed a smile this Tuesday: 10-month-old baby KJ, who received a bespoke gene-editing therapy after a six month scientific sprint - "graduated" from the hospital @childrensphila.bsky.social today and went HOME!
YAY SCIENCE!
Here's his story: wapo.st/451ZQjT
YAY SCIENCE!
Here's his story: wapo.st/451ZQjT