SchmitzStreitsLAB
@schmitzstreitslab.bsky.social
We are interested in #archaea,#regulation,#ncRNA,#smallproteins & novel biomolecules from nature, CAU Kiel
https://www.mikrobio.uni-kiel.de/de/ag-schmitz-streit
Views are our own
https://www.mikrobio.uni-kiel.de/de/ag-schmitz-streit
Views are our own
Pinned
Small ORF16 modulates the Mtr complex activity in Methanosarcina mazei Gö1 depending on the molecular hydrogen availability
Small open reading frame (small ORF)-encoded proteins, with less than 100 amino acids in length, have attracted increasing attention over the past decade after being largely overlooked due to limitati...
www.biorxiv.org
Check out our latest preprint on small proteins with big impact: MtrR fine-tunes energy metabolism in M.mazei by modulating the Mtr complex in response to H₂. Great work of Tim Habenicht + @SPP2002 collegues + @schullerjm.bsky.social - congrats TIM, 2. step to PhD!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by SchmitzStreitsLAB
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
www.nature.com
November 24, 2025 at 9:12 PM
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
Reposted by SchmitzStreitsLAB
🌍 World Antimicrobial Awareness Week 2025 🦠
Antimicrobial resistance threatens global health.
Unnecessary antibiotic use accelerates resistance and makes infections harder to treat.
Use antibiotics responsibly and help raise awareness.
Act now!
youtu.be/_Qy3aTKiVLE
#WWAW2025 #AMR #GoBlue
Antimicrobial resistance threatens global health.
Unnecessary antibiotic use accelerates resistance and makes infections harder to treat.
Use antibiotics responsibly and help raise awareness.
Act now!
youtu.be/_Qy3aTKiVLE
#WWAW2025 #AMR #GoBlue
WAAW - World Antimicrobial Awareness Week
YouTube video by CMFI - Cluster of Excellence
youtu.be
November 19, 2025 at 1:30 PM
🌍 World Antimicrobial Awareness Week 2025 🦠
Antimicrobial resistance threatens global health.
Unnecessary antibiotic use accelerates resistance and makes infections harder to treat.
Use antibiotics responsibly and help raise awareness.
Act now!
youtu.be/_Qy3aTKiVLE
#WWAW2025 #AMR #GoBlue
Antimicrobial resistance threatens global health.
Unnecessary antibiotic use accelerates resistance and makes infections harder to treat.
Use antibiotics responsibly and help raise awareness.
Act now!
youtu.be/_Qy3aTKiVLE
#WWAW2025 #AMR #GoBlue
Reposted by SchmitzStreitsLAB
Our paper describing the GlobDB is now published in @bioinfoadv.bsky.social
doi.org/10.1093/bioa...
The GlobDB is the largest species dereplicated genome database currently available, containing 306,260 species representatives.
More information on globdb.org 1/5
🖥️🧬🦠
doi.org/10.1093/bioa...
The GlobDB is the largest species dereplicated genome database currently available, containing 306,260 species representatives.
More information on globdb.org 1/5
🖥️🧬🦠
GlobDB: a comprehensive species-dereplicated microbial genome resource
AbstractMotivation. Over the past years, substantial numbers of microbial species’ genomes have been deposited outside of conventional INSDC databases.Resu
doi.org
November 21, 2025 at 4:21 PM
Our paper describing the GlobDB is now published in @bioinfoadv.bsky.social
doi.org/10.1093/bioa...
The GlobDB is the largest species dereplicated genome database currently available, containing 306,260 species representatives.
More information on globdb.org 1/5
🖥️🧬🦠
doi.org/10.1093/bioa...
The GlobDB is the largest species dereplicated genome database currently available, containing 306,260 species representatives.
More information on globdb.org 1/5
🖥️🧬🦠
Reposted by SchmitzStreitsLAB
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 8:40 PM
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Reposted by SchmitzStreitsLAB
#NatMicroPicks
CRISPR Metagenome Engineering! 🦠🔧🧬
MetaEdit enables precise genetic editing of native gut bacteria in mice.
#MicroSky #SynBio
www.science.org/doi/10.1126/...
CRISPR Metagenome Engineering! 🦠🔧🧬
MetaEdit enables precise genetic editing of native gut bacteria in mice.
#MicroSky #SynBio
www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 20, 2025 at 5:16 PM
#NatMicroPicks
CRISPR Metagenome Engineering! 🦠🔧🧬
MetaEdit enables precise genetic editing of native gut bacteria in mice.
#MicroSky #SynBio
www.science.org/doi/10.1126/...
CRISPR Metagenome Engineering! 🦠🔧🧬
MetaEdit enables precise genetic editing of native gut bacteria in mice.
#MicroSky #SynBio
www.science.org/doi/10.1126/...
Reposted by SchmitzStreitsLAB
Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
November 19, 2025 at 3:17 PM
Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
Reposted by SchmitzStreitsLAB
Clone-FISH paper out: Manuscript/resource alert #microsky 🦠 We present a collection of 30 E. coli (CloneFISH) cultures, each carrying a plasmid for the heterologous expression of a (near) full-length 16S rRNA gene from one of 30 lineages of archaea, including 17 yet uncultured ones.
November 17, 2025 at 2:36 PM
Clone-FISH paper out: Manuscript/resource alert #microsky 🦠 We present a collection of 30 E. coli (CloneFISH) cultures, each carrying a plasmid for the heterologous expression of a (near) full-length 16S rRNA gene from one of 30 lineages of archaea, including 17 yet uncultured ones.
Reposted by SchmitzStreitsLAB
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis www.nature.com/articles/s41...
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
the sun is shining through the clouds in the sky above the ocean
ALT: the sun is shining through the clouds in the sky above the ocean
media.tenor.com
November 12, 2025 at 4:00 PM
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis www.nature.com/articles/s41...
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
Reposted by SchmitzStreitsLAB
Reposted by SchmitzStreitsLAB
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by SchmitzStreitsLAB
Starting this week, I set aside one hour each week to meet ECRs outside my group who want to discuss career development, mentorship, or any non-technical professional questions.
Here is a blog that explains my motivation for this and how to schedule a meeting:
merenlab.org/2025/11/16/E...
Here is a blog that explains my motivation for this and how to schedule a meeting:
merenlab.org/2025/11/16/E...
ECR connection: Meet Meren when you need to
A means for ECRs to get advice from a senior scientist outside of their support network
merenlab.org
November 16, 2025 at 4:56 PM
Starting this week, I set aside one hour each week to meet ECRs outside my group who want to discuss career development, mentorship, or any non-technical professional questions.
Here is a blog that explains my motivation for this and how to schedule a meeting:
merenlab.org/2025/11/16/E...
Here is a blog that explains my motivation for this and how to schedule a meeting:
merenlab.org/2025/11/16/E...
Reposted by SchmitzStreitsLAB
1/6
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
November 12, 2025 at 7:53 AM
1/6
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
Reposted by SchmitzStreitsLAB
An Asgard archaeon containing internal membrane compartments!! 😯
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
An Asgard archaeon with internal membrane compartments
The emergence of eukaryotes from a merger between an archaeon and a bacterial cell ~two billion years ago involved a profound change in cellular organisation. While the order in which different featur...
www.biorxiv.org
November 8, 2025 at 5:15 PM
An Asgard archaeon containing internal membrane compartments!! 😯
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
Reposted by SchmitzStreitsLAB
New article online: Modulation of archaeal hypernucleosome structure and stability by Mg2+
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
Modulation of archaeal hypernucleosome structure and stability by Mg2+
DNA-wrapping histone proteins play a central role in chromatin organization, gene expression and regulation in most eukaryotes and archaea. While the …
www.sciencedirect.com
November 6, 2025 at 7:53 AM
New article online: Modulation of archaeal hypernucleosome structure and stability by Mg2+
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
Reposted by SchmitzStreitsLAB
Preprint: Bacteria sense virus-induced genome degradation via methylated mononucleotides
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
November 6, 2025 at 10:39 AM
Preprint: Bacteria sense virus-induced genome degradation via methylated mononucleotides
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
Reposted by SchmitzStreitsLAB
True!
Scientists feel that the pressure to publish is rising, but that the time and resources they have to do the necessary research are falling, according to a survey of 3,200 researchers
go.nature.com/4hNDvuN
go.nature.com/4hNDvuN
Pressure to publish is rising as research time shrinks, finds survey of scientists
Researchers feel that pressures to publish are increasing, but the time and resources available to do research are decreasing, according to a survey by Elsevier.
go.nature.com
November 7, 2025 at 2:19 PM
True!
Reposted by SchmitzStreitsLAB
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
DNA scientist James Watson has a remarkably long history of sexist, racist public comments
“People say it would be terrible if we made all girls pretty,” he said in 2003. “I think it would be great.”
www.vox.com
November 7, 2025 at 7:45 PM
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
Reposted by SchmitzStreitsLAB
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
www.science.org
November 7, 2025 at 7:58 PM
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Reposted by SchmitzStreitsLAB
Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.
November 5, 2025 at 12:57 PM
Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.
Reposted by SchmitzStreitsLAB
Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab!
For more information and how to apply, see below 👇
Please RT!
For more information and how to apply, see below 👇
Please RT!
📢 The #HIRI is looking for a #postdoc & a #PhD student to join the research group of @jenshoer.bsky.social. His lab focuses on understanding the molecular mechanisms of #phages with #RNA genomes during infection, host takeover & anti-phage defense. 🧫🦠 More info: www.helmholtz-hiri.de/en/jobs-tale...
Working at HIRI
At the HIRI, we do not just value excellent research. Short distances, an open door policy, and a good working atmosphere—this is what distinguishes us from others. Have a look at our current job…
www.helmholtz-hiri.de
October 17, 2025 at 12:52 PM
Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab!
For more information and how to apply, see below 👇
Please RT!
For more information and how to apply, see below 👇
Please RT!
Reposted by SchmitzStreitsLAB
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
November 2, 2025 at 7:13 PM
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
Reposted by SchmitzStreitsLAB
🌊 Wie geht nachhaltiger #Küstenschutz? Statt nur auf höhere Deiche zu setzen, sucht Dr. Claudia Wolff @uni-kiel.de mit Gemeinden, Behörden und NGOs nach neuen Wegen.
Wir drücken die Daumen und unterstützen mit einem "Change! Fellowship"!
#Forschung #Nachhaltigkeit #Klimawandel #Ostsee
Wir drücken die Daumen und unterstützen mit einem "Change! Fellowship"!
#Forschung #Nachhaltigkeit #Klimawandel #Ostsee
Küsten unter Druck – Neue Strategien für den Küstenschutz | VolkswagenStiftung
Sturmfluten, steigende Pegel, gefährdete Küsten: Dr. Claudia Wolff von der Universität Kiel sucht im Rahmen ihres "Change!-Fellowships" gemeinsam mit lokalen Akteur:innen nach neuen Wegen für nachhalt...
www.volkswagenstiftung.de
November 3, 2025 at 8:02 AM
🌊 Wie geht nachhaltiger #Küstenschutz? Statt nur auf höhere Deiche zu setzen, sucht Dr. Claudia Wolff @uni-kiel.de mit Gemeinden, Behörden und NGOs nach neuen Wegen.
Wir drücken die Daumen und unterstützen mit einem "Change! Fellowship"!
#Forschung #Nachhaltigkeit #Klimawandel #Ostsee
Wir drücken die Daumen und unterstützen mit einem "Change! Fellowship"!
#Forschung #Nachhaltigkeit #Klimawandel #Ostsee
Reposted by SchmitzStreitsLAB
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 27, 2025 at 1:19 PM
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Reposted by SchmitzStreitsLAB
Do you want to do a Masters in Evolutionary Biology? The call for applying to the MEME program is now open! MEME is a fantastic 2-year MSc between four European Universities on all areas of Evolutionary Biology. Apply and study in Sweden/France/the Netherlands/Germany/USA/Switzerland! www.evobio.eu
October 24, 2025 at 9:04 AM
Do you want to do a Masters in Evolutionary Biology? The call for applying to the MEME program is now open! MEME is a fantastic 2-year MSc between four European Universities on all areas of Evolutionary Biology. Apply and study in Sweden/France/the Netherlands/Germany/USA/Switzerland! www.evobio.eu
Reposted by SchmitzStreitsLAB
In 4 Wochen ist es soweit: Am 21. November findet die Night of the Profs 2025 an der @uni-kiel.de statt. 🌕
Auch die Science Show ist wieder vertreten: Um 20:00 und um 21:00 Uhr, jeweils im Frederik-Paulsen-Hörsaal im Audimax, geben unsere Referent*innen kurze Einblicke in ihre Forschungen. 💡
Auch die Science Show ist wieder vertreten: Um 20:00 und um 21:00 Uhr, jeweils im Frederik-Paulsen-Hörsaal im Audimax, geben unsere Referent*innen kurze Einblicke in ihre Forschungen. 💡
October 24, 2025 at 12:22 PM
In 4 Wochen ist es soweit: Am 21. November findet die Night of the Profs 2025 an der @uni-kiel.de statt. 🌕
Auch die Science Show ist wieder vertreten: Um 20:00 und um 21:00 Uhr, jeweils im Frederik-Paulsen-Hörsaal im Audimax, geben unsere Referent*innen kurze Einblicke in ihre Forschungen. 💡
Auch die Science Show ist wieder vertreten: Um 20:00 und um 21:00 Uhr, jeweils im Frederik-Paulsen-Hörsaal im Audimax, geben unsere Referent*innen kurze Einblicke in ihre Forschungen. 💡