Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
<em>Journal of Internal Medicine</em> | Wiley Online Library
Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composit...
onlinelibrary.wiley.com
November 27, 2025 at 9:04 AM
Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by haysamrady
Low rates of testing could mean that up to two thirds of people at risk for chronic kidney disease may have unrecognised albuminuria.
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
November 26, 2025 at 1:28 PM
Low rates of testing could mean that up to two thirds of people at risk for chronic kidney disease may have unrecognised albuminuria.
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
Reposted by haysamrady
Case report: Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome
#nephsky
#nephsky
Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome - Pediatric Nephrology
Frequently relapsing, steroid-dependent nephrotic syndrome (FRNS/SDNS) remains a therapeutic challenge. Rituximab, a B-cell-depleting agent, is effective and widely used for FRNS/SDNS, but its use…
buff.ly
November 26, 2025 at 2:01 PM
Case report: Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome
#nephsky
#nephsky
Reposted by haysamrady
November 26, 2025 at 2:08 PM
Reposted by haysamrady
So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathsky #nephsky
November 26, 2025 at 11:51 PM
So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathsky #nephsky
Reposted by haysamrady
Cholemic Nephropathy aka Cholemic Nephrosis aka Bile Acid/ Bile Cast Nephropathy ca. 2024
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
November 26, 2025 at 10:43 PM
Cholemic Nephropathy aka Cholemic Nephrosis aka Bile Acid/ Bile Cast Nephropathy ca. 2024
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
Reposted by haysamrady
Apixaban and warfarin being similar is also a red flag
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis: A Pilot Randomized Controlled Trial - PubMed
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2025_04_09_ASN0000000000000495.mp3 …
pubmed.ncbi.nlm.nih.gov
November 26, 2025 at 11:10 PM
Apixaban and warfarin being similar is also a red flag
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
Reposted by haysamrady
Sibeprenlimab: First @fda.gov approved therapy targeting B cells which produce the abnormal antibodies responsible for #IgAN, addressing the fundamental cause
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
November 27, 2025 at 2:40 AM
Sibeprenlimab: First @fda.gov approved therapy targeting B cells which produce the abnormal antibodies responsible for #IgAN, addressing the fundamental cause
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
Antimeningococcal protection in patients receiving terminal complement inhibitors
#nephsky #nephrology
www.kireports.org/article/S246...
#nephsky #nephrology
www.kireports.org/article/S246...
Antimeningococcal protection in patients receiving terminal complement inhibitors
C5 inhibitor (C5i) therapy markedly increases susceptibility to invasive meningococcal
disease (IMD) by blocking the terminal complement pathway essential for defense against
Neisseria meningitidis. V...
www.kireports.org
November 26, 2025 at 6:46 AM
Antimeningococcal protection in patients receiving terminal complement inhibitors
#nephsky #nephrology
www.kireports.org/article/S246...
#nephsky #nephrology
www.kireports.org/article/S246...
Reposted by haysamrady
Interesting read on the protective p.N264k (M1) #APOL1 variant and #kidneydisease and #FSGS.
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
Prevalence of the M1 Modifier p.N264K in APOL1 Among Individuals With Kidney Disease Undergoing Commercial Genetic Testing in the United States
bit.ly/48PB2xk (FREE)
bit.ly/48PB2xk (FREE)
November 25, 2025 at 2:02 PM
Interesting read on the protective p.N264k (M1) #APOL1 variant and #kidneydisease and #FSGS.
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
Reposted by haysamrady
Just received my complimentary copy of Tropical Nephrology (2nd Ed.) 📘🌿
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
November 25, 2025 at 4:57 PM
Reposted by haysamrady
(1/2) The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow).
#TeachingPoints #kidneypath #renal
#TeachingPoints #kidneypath #renal
November 25, 2025 at 5:21 PM
(1/2) The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow).
#TeachingPoints #kidneypath #renal
#TeachingPoints #kidneypath #renal
Reposted by haysamrady
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
November 26, 2025 at 12:21 AM
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
Reposted by haysamrady
#NephJCshort on BICAR-ICU2 #Medsky #Nephsky
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
Dialysis deferred, logic recycled: BICAR ICU2 — NephJC
NephJC short on BICAR-ICU2
www.nephjc.com
November 25, 2025 at 12:19 AM
#NephJCshort on BICAR-ICU2 #Medsky #Nephsky
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
Reposted by haysamrady
Save the kidneys! Outpt AKI in cirrhosis
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
November 23, 2025 at 1:19 PM
Save the kidneys! Outpt AKI in cirrhosis
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
Reposted by haysamrady
Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky
November 23, 2025 at 3:50 PM
Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky
Reposted by haysamrady
Also somewhat surprising: risk of infection related badness in lupus = risk of infection related badness in diabetic kidney disease!
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
November 23, 2025 at 2:50 PM
Also somewhat surprising: risk of infection related badness in lupus = risk of infection related badness in diabetic kidney disease!
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
Reposted by haysamrady
Another interesting @kidneyint.bsky.social cohort study
www.kidney-international.org/article/S008...
Infection risk in kidney disease - lupus > ANCA, perhaps as ANCA is one and done (usually) whereas #lupus is never done?
Lupus > other primary and ADPKD is not surprising
#NephSky
www.kidney-international.org/article/S008...
Infection risk in kidney disease - lupus > ANCA, perhaps as ANCA is one and done (usually) whereas #lupus is never done?
Lupus > other primary and ADPKD is not surprising
#NephSky
November 23, 2025 at 1:53 PM
Another interesting @kidneyint.bsky.social cohort study
www.kidney-international.org/article/S008...
Infection risk in kidney disease - lupus > ANCA, perhaps as ANCA is one and done (usually) whereas #lupus is never done?
Lupus > other primary and ADPKD is not surprising
#NephSky
www.kidney-international.org/article/S008...
Infection risk in kidney disease - lupus > ANCA, perhaps as ANCA is one and done (usually) whereas #lupus is never done?
Lupus > other primary and ADPKD is not surprising
#NephSky
Reposted by haysamrady
Optimizing fun while in anticipation of receiving bad medical news around a major holiday
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
Optimizing fun while receiving bad medical news around a major holiday.
Men, if you are facing a potentially life altering disease and you have the option to find out one week BEFORE or one week AFTER a major holiday, you should near always opt for the AFTER option.
christosargyropoulos.substack.com
November 22, 2025 at 4:45 PM
Optimizing fun while in anticipation of receiving bad medical news around a major holiday
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
Reposted by haysamrady
a fancy nephrology guideline trying to describe how to titrate a norepi gtt is sending me 🤣
adjust q4hr??
the whole point of a NE gtt in HRS-AKI is immediate BP control
tell the ICU RN the target MAP and they will achieve it immediately... that's why NE gtts are great
(and peripheral IV is fine)
adjust q4hr??
the whole point of a NE gtt in HRS-AKI is immediate BP control
tell the ICU RN the target MAP and they will achieve it immediately... that's why NE gtts are great
(and peripheral IV is fine)
November 22, 2025 at 8:57 PM
a fancy nephrology guideline trying to describe how to titrate a norepi gtt is sending me 🤣
adjust q4hr??
the whole point of a NE gtt in HRS-AKI is immediate BP control
tell the ICU RN the target MAP and they will achieve it immediately... that's why NE gtts are great
(and peripheral IV is fine)
adjust q4hr??
the whole point of a NE gtt in HRS-AKI is immediate BP control
tell the ICU RN the target MAP and they will achieve it immediately... that's why NE gtts are great
(and peripheral IV is fine)
HLA-B Leader Dimorphism Predicts BK Polyomavirus Replication After Kidney Transplant
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
November 23, 2025 at 12:41 AM
HLA-B Leader Dimorphism Predicts BK Polyomavirus Replication After Kidney Transplant
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by haysamrady
Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. pubmed.ncbi.nlm.nih.gov/31871855/ #renalpath #pathsky #nephsky
November 21, 2025 at 3:11 PM
Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. pubmed.ncbi.nlm.nih.gov/31871855/ #renalpath #pathsky #nephsky
Reposted by haysamrady
🧵 New #Skeetorial Drop! 🧵
1/ Hey #NephSky! 👋
We’re back with a fresh #Skeetorial from @kireports.bsky.social , this time diving into:
Dapagliflozin in Stage 4 CKD: no diabetes required? 🤔
Let’s unpack what this trial means for your next CKD patient. 💊💭
1/ Hey #NephSky! 👋
We’re back with a fresh #Skeetorial from @kireports.bsky.social , this time diving into:
Dapagliflozin in Stage 4 CKD: no diabetes required? 🤔
Let’s unpack what this trial means for your next CKD patient. 💊💭
November 20, 2025 at 6:47 PM
🧵 New #Skeetorial Drop! 🧵
1/ Hey #NephSky! 👋
We’re back with a fresh #Skeetorial from @kireports.bsky.social , this time diving into:
Dapagliflozin in Stage 4 CKD: no diabetes required? 🤔
Let’s unpack what this trial means for your next CKD patient. 💊💭
1/ Hey #NephSky! 👋
We’re back with a fresh #Skeetorial from @kireports.bsky.social , this time diving into:
Dapagliflozin in Stage 4 CKD: no diabetes required? 🤔
Let’s unpack what this trial means for your next CKD patient. 💊💭
Reposted by haysamrady
Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathsky #nephsky.
November 20, 2025 at 1:01 PM
Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathsky #nephsky.
Reposted by haysamrady
Another #KidneyWk, another showcase for #IgAN therapies. Joel Topf @kidneyboy.bsky.social spoke with Jonathan Barratt about his trials of mezagitamab and atacicept. #nephsky #nephrology #iganephropathy www.docwirenews.com/post/mezagit...
Mezagitamab, Atacicept, and the Rise of IgAN Therapies | Docwire News
Joel Topf, MD, spoke with Jonathan Barratt, PhD, about his Kidney Week presentations on mezagitamab and atacicept and the landscape of IgA nephropathy (IgAN).
www.docwirenews.com
November 20, 2025 at 10:40 PM
Another #KidneyWk, another showcase for #IgAN therapies. Joel Topf @kidneyboy.bsky.social spoke with Jonathan Barratt about his trials of mezagitamab and atacicept. #nephsky #nephrology #iganephropathy www.docwirenews.com/post/mezagit...