Lightnews — Scholar-powered news

Reposted by Schmitt-Mechulam Lab

Wilson Lab @wilsonlab.bsky.social · Mar 26

www.nature.com/articles/s41...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

www.nature.com

1 16 39

Reposted by Schmitt-Mechulam Lab

Sergey Melnikov @sergeymelnikov.bsky.social · Mar 20

Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...

Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications

Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

www.nature.com

1 23 45

Schmitt-Mechulam Lab @tbioc.bsky.social · Mar 13

Great news! Congratulations.

1

Reposted by Schmitt-Mechulam Lab

Manuel Thery @manuelthery.bsky.social · Mar 5

Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !

77 63

Reposted by Schmitt-Mechulam Lab

Denis Chrétien @dchretien.bsky.social · Mar 13

Scrat (JEOL ARM 200) is now installed in Rennes with a Direct Electron Apollo camera. Don't hesitate to get in touch if you need nice SPA or cryo-electron tomography (single and dual axis) data 😍
biosit.univ-rennes.fr/en/tem2c
#CryoEM

This image shows the new Cryo-electron microscope JEOL ARM 200 installed on the TEM2C platform in Rennes, France, together with Reynald Gillet (Left, Director of the Institute of Genetics and Development of Rennes), and Denis Chrétien (right, in charge of the project).

2 7 18

Reposted by Schmitt-Mechulam Lab

Joachim Frank @joachim123.bsky.social · Mar 9

I think it's important to reach out to your own community and explain what the funding cuts mean in practice.

8 76 340

Reposted by Schmitt-Mechulam Lab

Nature Reviews Genetics @natrevgenet.nature.com · Feb 17

FYI: New online! Cytoplasmic mRNA decay and quality control machineries in eukaryotes

Cytoplasmic mRNA decay and quality control machineries in eukaryotes

Nature Reviews Genetics, Published online: 27 January 2025; doi:10.1038/s41576-024-00810-1In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and…

www.nature.com

1 5 19

Reposted by Schmitt-Mechulam Lab

Arthur Charles-Orszag @acharlesorszag.bsky.social · Feb 5

Mark your calendars! Archaea power hour is back!

Archaea Power Hour @archaeapowerhour.bsky.social · Feb 5

Archaea Power Hour is back next week on WEDNESDAY, Feb. 12th at 10 AM EST / 4 PM CET! Make sure to attend and show your love for archaea this coming Valentine's week 😍🥰♥️!!! Join our mailing list to receive the Zoom link: t.co/b17JFAaZQ6.

11 18

Reposted by Schmitt-Mechulam Lab

Molecular Microbiology Editors @molecularmicro.bsky.social · Feb 4

New Review: DNA topoisomerase in Archaea; from Paul Villain and Tamara Basta...featured in a forthcoming special issue on Prokaryotic Chromosome Organization!
#MicroSky

onlinelibrary.wiley.com/doi/10.1111/...

Regulation of DNA Topology in Archaea: State of the Art and Perspectives

DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the curren...

onlinelibrary.wiley.com

5 7

Reposted by Schmitt-Mechulam Lab

Clément Madru @cryoclem.bsky.social · Jan 30

First ribosome purification using poly-lysine beads (RAPPL, developed by @djuranoviclab.bsky.social & collaborators: www.biorxiv.org/content/10.1...). Full process—from lysis to grid prep—in just 3 hours. Look how pretty it is (even if a bit too diluted)! This is a game-changer🚀.

1 2 16

Reposted by Schmitt-Mechulam Lab

David McQuarrie @davidmcquarrie.bsky.social · Jan 28

NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure
doi.org/10.1016/j.st...

#RNA #RNAsky #RNAbiology

NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure

In their structural analysis of the NSUN6-SFG-mRNA ternary complex, Zhong et al. identified a compound known as thiamine disulfide through NMR and virtual screening. This compound has subsequently bee...

www.cell.com

4 7

Reposted by Schmitt-Mechulam Lab

Rémi Fronzes @fronzeslab.bsky.social · Jan 28

Voici un exemple concret des conséquences du manque de crédit dans la recherche française.
Nous avons deux microscopes électroniques de pointe à Bordeaux pour la biologie structurale et cellulaire.

Faute de moyens suffisants, nous devrons très probablement arrêter l'un des deux instruments…

6 4 10

Reposted by Schmitt-Mechulam Lab

Christophe Le Clainche @actin-paris-saclay.bsky.social · Jan 27

The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology.

Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University.

Application deadline: Feb 28, 2025

www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social

47 34

Reposted by Schmitt-Mechulam Lab

Cameron Thrash @jcamthrash.bsky.social · Jan 23

The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics www.nature.com/articles/s41... #jcampubs

The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics - Nature Microbiology

Eukaryotic Arf family proteins involved in endomembrane organelle dynamics arose from the Asgard archaeal ArfR GTPases, indicating this capability likely originated in the archaeal ancestor of eukaryo...

www.nature.com

9 10

Reposted by Schmitt-Mechulam Lab

Sorek Lab @soreklab.bsky.social · Jan 23

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity

Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors

A 🧵 1/10

www.cell.com/cell/abstrac...

Structure-guided discovery of viral proteins that inhibit host immunity

Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

www.cell.com

1 74 200

Reposted by Schmitt-Mechulam Lab

RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS @aribio.bsky.social · Dec 6

Bonjour, nous avons un poste d´IE en biochimie et biologie moléculaire ouvert en mobilité interne (FSEP) au laboratoire de biologie structurale de la cellule (BIOC) située au sein de l´École polytechnique (Palaiseau) .

emploi.cnrs.fr/Offres/MOBIN...

Portail Emploi CNRS - Offre d'emploi - Ingénieur d'études en biochimie et en biologie moléculaire H/F

emploi.cnrs.fr

1 6 6

Reposted by Schmitt-Mechulam Lab

Clément Madru @cryoclem.bsky.social · Jan 18

A new year, a new social network and a new article in @naturecomms.bsky.social ! It unveils how archaeal RPA orchestrates the recruitment of key players in 🧬 replication primase and polD through its WH domain, with structures of both complexes!!
rdcu.be/d6GAY

Communication between DNA polymerases and Replication Protein A within the archaeal replisome

Nature Communications - The single stranded DNA binding protein RPA plays a pivotal role in DNA replication. The archaeal RPA hosts a WH domain that interacts with the DNA primase and the...

rdcu.be

8 16

Reposted by Schmitt-Mechulam Lab

Rashmi Agrata @rashmiagrata.bsky.social · Jan 17

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩

Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin
Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

@cellpress.bsky.social
@wehi-research.bsky.social

'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell

1 23 56

Reposted by Schmitt-Mechulam Lab

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Dec 16

More ribosome structures solved by RAPPL (collaboration with Pavlovic Djuranovic and Hashem Labs). This one is bacterial from 2ml culture and using method described in our preprint.

www.biorxiv.org/content/10.1...

17 39

Reposted by Schmitt-Mechulam Lab

König Lab @koenig-lab.bsky.social · Jan 15

Check out our recent work on CDS #m6A mediated RNA decay (CMD)! Decay relies on ribosome pausing at m6A containing codons. Great collab with the Zarnack lab & colleagues. Thank you @uniwuerzburg.bsky.social , @imbmainz.bsky.social and RMap🥳

www.cell.com/molecular-ce...

18 48

Reposted by Schmitt-Mechulam Lab

Korostelev Lab @korostelevlab.bsky.social · Jan 13

Gabriel Demo and colleagues found how a small archaeal protein (aRDF) dimerizes 30S subunits to prevent ribosome formation:

Frances Yap @ribo1214.bsky.social · Jan 13

A growing list of anti-association factors, this time a 30S-dimerization factor in archaea #Ribosome #RNASky 🧪 ⤵️ doi.org/10.1093/nar/...

Novel archaeal ribosome dimerization factor facilitating unique 30S–30S dimerization

Abstract. Protein synthesis (translation) consumes a substantial proportion of cellular resources, prompting specialized mechanisms to reduce translation u

doi.org

3 6

Reposted by Schmitt-Mechulam Lab

Tamara Basta @tamarabasta.bsky.social · Jan 14

I am happy to share that the review my former PhD student Paul Villain and I wrote was published: doi.org/10.1111/mmi....
#Archaea
#I2BC

Regulation of DNA Topology in Archaea: State of the Art and Perspectives

DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the curren....

doi.org

1 15 31

Reposted by Schmitt-Mechulam Lab

Luc Buée @lucbuee.bsky.social · Jan 11

Mapt mutations are found in brain disorders. Most of them are located in sequences encoding microtubule-binding domains. However, some are in the 5'UTR tau mRNAs. Understanding the effect of mutations in the amino-terminal part of tau and the role of N-truncated tau academic.oup.com/narmolmed/ar...

FTLD-MAPT mutations and short 5′UTR Tau mRNAs increase Tau translation

Abstract. Tau protein plays a central role in Alzheimer’s disease (AD) and other tauopathies. Tau proteins aggregate in degenerating neurons and their expr

academic.oup.com

5 10

Schmitt-Mechulam Lab @tbioc.bsky.social · Jan 16

We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg

11 23