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Reposted by Ben S. Huang

Allen Institute @alleninstitute.org · 23d

Neuroscientists around the world use Brain Map to accelerate their research.

🧠📈 Explore the massive, free library of datasets, protocols, computational tools, and more at portal.brain-map.org

#OpenScienceWeek

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Reposted by Ben S. Huang

arnau-m-l @arnauya.bsky.social · 28d

An in-depth perspective piece discussing the transformative impact of AI coding tools in neuroscience research, featuring my work on SpikeAgent and AI interfaces for neural data analysis. @zuwan-lin.bsky.social
www.thetransmitter.org/craft-and-ca...

Should neuroscientists ‘vibe code’?

Researchers are developing software entirely through natural language conversations with advanced large language models. The trend is transforming how research gets done—but it also presents new…

www.thetransmitter.org

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Reposted by Ben S. Huang

Mike X Cohen PhD, Sincxpress Education @mikexcohen.bsky.social · 28d

Dear bluesky neuroscientists: You should pay attention to the field of LLM mechanistic interpretability.

Not because LLMs are like real brains (they are absolutely nothing alike), but because mech interp analysis methods would be useful in neuroscience.

Start learning here: tinyurl.com/48pum4pb

LLM breakdown 1/6: Tokenization (words to integers)

Large language models can't read; instead, they are given numbers that come from text.

mikexcohen.substack.com

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Reposted by Ben S. Huang

PessoaBrain @pessoabrain.bsky.social · 29d

𝗕𝗿𝗮𝗶𝗻-𝘄𝗶𝗱𝗲 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀
Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice
𝗕𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻𝘀 𝗼𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝘁𝗵𝗿𝗲𝗮𝗱𝘀?
Dynamical processing winding through most brain regions.
Looks like a must read.
www.biorxiv.org/content/10.1...
#neuroskyence

Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice

Until recently, it has been possible to examine activity in the brain globally through regional averaging or locally at cellular resolution. These studies characterized regions as functionally homogen...

www.biorxiv.org

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Reposted by Ben S. Huang

Addgene @addgene.bsky.social · 29d

Science is a team effort, and the @alleninstitute.org has put in a lot of effort! They screened thousands of AAV enhancers to find the best and brightest, culminating in the AAV Enhancer Collection at Addgene. Learn more about all of the details in our newest blog post!

blog.addgene.org

"Hall of Fame" AAV Enhancers from the Allen Institute for Brain Science

twp.ai

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Reposted by Ben S. Huang

openRxiv @openrxiv.bsky.social · Jul 29

You're in research because you want to advance science, share your results with others, grow in your career & connect with the community.

Here are 7 reasons why posting preprints on bioRxiv & medRxiv can help you meet those goals. 💚

#OpenScience #Preprints #ScienceCommunication #bioRxiv #medRxiv

7 Reasons to post a preprint

1 Accelerate science. Papers are rapidly online and freely accessible.

2 Retain control. Share your research fast when you want to

3 Get early recognition. Preprints get a DOI on posting and can be cited.

4 Advance your career. Cite your preprints in grant and job applications.

5 Improve your paper. Get feedback and update your preprint.

6 Build your community. Increase your network and collaboration.

7 Speed up journal submission. Easily transfer your manuscript to many journals.

openRxiv

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Reposted by Ben S. Huang

Ann Kennedy @antihebbiann.bsky.social · Aug 20

I wrote a Comment on neurotheory, and now you can read it!

Some thoughts on where neurotheory has and has not taken root within the neuroscience community, how it has shaped those subfields, and where we theorists might look next for fresh adventures.

www.nature.com/articles/s41...

Theoretical neuroscience has room to grow

Nature Reviews Neuroscience - The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine...

www.nature.com

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Ben S. Huang @ben-s-huang.bsky.social · Aug 20

flight risk

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Reposted by Ben S. Huang

Masha Prager-Khoutorsky @mashapk.bsky.social · Aug 19

Thrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉

Neuron @cp-neuron.bsky.social · Aug 19

Online now:

Microglia regulate neuronal activity via structural remodeling of astrocytes

Gu et al. showed that in rats fed a high-salt diet, reactive microglia accumulate around vasopressin-secreting neurons, phagocytosing astrocytic elements and pruning astrocytes. This causes glutamate spillover, increased neuronal activity, and excessive vasopressin release, contributing to salt-induced hypertension. The study reveals a novel mechanism by which microglia regulate synaptic transmission and neuronal activity through structural remodeling of astrocytes in the adult brain.

dlvr.it

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Reposted by Ben S. Huang

Andy Moore @aaandmoore.bsky.social · Aug 18

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

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Reposted by Ben S. Huang

FlyBase @flybase.bsky.social · Aug 15

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

FlyBase:Contribute to FlyBase - FlyBase Wiki

wiki.flybase.org

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Reposted by Ben S. Huang

Waggoner Lab @labwaggoner.bsky.social · Aug 12

VIVIT: Resolving trans-scale volumetric biological architectures via ionic glassy tissue @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

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Reposted by Ben S. Huang

Lucina Uddin @lucinauddin.bsky.social · Aug 10

Let’s do this www.universityofcalifornia.edu/get-involved...

Stand Up for UC

We must stand together to protect our students, staff, faculty and our mission.

www.universityofcalifornia.edu

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Reposted by Ben S. Huang

Ching-Lung Hsu @hiallen72.bsky.social · Aug 8

www.nature.com/articles/s41...

Multiplexed subspaces route neural activity across brain-wide networks - Nature Communications

How the brain flexibly engages different networks of regions to perform different cognitive processes remains unknown. Here, the authors show changing the geometry of a neural representation to align ...

www.nature.com

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Reposted by Ben S. Huang

Allen Institute @alleninstitute.org · Jul 28

New electron microscopy study in @nature.com Neuroscience finds that layer 5 ET neurons mostly connect to inhibitory cells locally, esp. those suppressing other excitatory cells, suggesting a "winner-take-all" system.

🧠📈 www.nature.com/articles/s41...

The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex - Nature Neuroscience

This study maps the connections of layer 5 pyramidal neurons in the mouse cortex, revealing distinct local and intercortical wiring patterns, and provides an open framework for exploring the connectiv...

www.nature.com

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Reposted by Ben S. Huang

Eric Topol @erictopol.bsky.social · Jul 17

A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

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Reposted by Ben S. Huang

Alexey Amunts @amunts.bsky.social · Jul 16

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...

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Reposted by Ben S. Huang

Uilliam Mac ᚒᚔᚂᚂᚔᚐᚋ @uilliammac.bsky.social · Jun 25

The complete Cosmos series by Carl Sagan is now available at the Internet Archive.

archive.org/details/Cosm...

h/t @[email protected] for spotting this.

@archive.org #cosmology #astronomy #science

Cosmos: A Personal Voyage (with Carl Sagan) : KCET : Free Download, Borrow, and Streaming : Internet Archive

Update 6/29/23: Ok, I am pretty sure all the episodes are now accounted for and labeled correctly.Astronomer Carl Sagan's landmark 13-part science series takes...

archive.org

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Reposted by Ben S. Huang

Sergiu P. Pasca @sergiuppasca.bsky.social · Jun 4

A few weeks ago, I talked to @neildegrassetyson.com on his StarTalk Radio about our efforts to understand human brain disorders with stem cell models including #assembloids. We touched on the promise of these technologies, the challenges & the mission behind the work

www.youtube.com/watch?v=HEBj...

Groundbreaking Studies Recreate Human Brain Circuits in a Dish

YouTube video by StarTalk

www.youtube.com

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Reposted by Ben S. Huang

Becky Stern @beckystern.bsky.social · Jun 27

Today I learned the @amnh.org is pay-what-you-wish for NY residents, making it easy to dip in for a quick visit with my new pal Apex Stegosaurus 😍

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Reposted by Ben S. Huang

Natalie Peluso 🧠🫁😊 @nataliepeluso.com · Jul 2

The dynamics and geometry of choice in the premotor cortex 🧠

Nature 2025
#neuroskyence

www.nature.com/articles/s41...

The dynamics and geometry of choice in the premotor cortex - Nature

A population code for the dynamics of choice formation in the primate premotor cortex is revealed, with diverse single-neuron tuning to a shared decision variable.

www.nature.com

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Ben S. Huang @ben-s-huang.bsky.social · Jul 5

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments www.science.org/doi/10.1126/...

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments

Spectroscopy, structural, and functional study of microbial rhodopsins with characteristic long-living near–UV-absorbing state.

www.science.org

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Reposted by Ben S. Huang

Marius Pachitariu @marius10p.bsky.social · Jun 24

Your brain learns for you even when you're not actively learning. Maybe. (in mice).

Janelia Research Campus @hhmijanelia.bsky.social · Jun 23

🚶Aimlessly wandering around a city or exploring the new mall may seem unproductive, but new research led by @zh0ng0.bsky.social @marius10p.bsky.social @computingnature.bsky.social suggests it could play an important role in how our brains learn.‬‬ 🧠
🔗 www.janelia.org/news/zoning-...

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Reposted by Ben S. Huang

Ben Kanter @beneuroscience.bsky.social · Jun 26

Our new paper out now in Science explores how neural activity in the lateral entorhinal cortex (LEC) *drifts* over time - and *jumps* at key boundaries - to help organize events in memory.

🔗 www.science.org/doi/10.1126/...

Here's a quick summary of what we found 🧵👇

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Reposted by Ben S. Huang

Nature @nature.com · Jun 25

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis

https://go.nature.com/46c474I

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature

A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.

go.nature.com

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